Article
Immunology
Xiaotong Lu, Jianyang Wang, Tao Zhang, Zongmei Zhou, Lei Deng, Xin Wang, Wenqing Wang, Wenyang Liu, Wei Tang, Zhijie Wang, Jie Wang, Wei Jiang, Nan Bi, Luhua Wang
Summary: This retrospective study investigated the risk of treatment-related pneumonitis in Chinese lung cancer patients who received thoracic radiotherapy (TRT) followed by immune checkpoint inhibitor (ICI) therapy. The results showed that the occurrence of pneumonitis was relatively high, but manageable, and dosimetric parameters could improve the prediction of radiation recall pneumonitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Danielle S. Bitterman, Philip Selesnick, Jeremy Bredfeldt, Christopher L. Williams, Christian Guthier, Elizabeth Huynh, David E. Kozono, John H. Lewis, Robert A. Cormack, Colin M. Carpenter, Raymond H. Mak, Katelyn M. Atkins
Summary: The study aimed to investigate the cardiac toxicity after intensity-modulated radiation therapy (IMRT) in patients with non-small cell lung cancer (NSCLC) and found that reducing mean heart dose (MHD) without increasing lung dose is feasible. The results showed that in some patients, the MHD could be reduced without violating the lung dose constraints, indicating potential benefits of more advanced radiation therapy technologies.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Medicine, General & Internal
Sara Torresan, Gaia Zussino, Francesco Cortiula, Alessandro Follador, Gianpiero Fasola, Rossano Girometti, Lorenzo Cereser
Summary: We report a case of radiation recall pneumonitis followed by immune-checkpoint inhibitor-induced pneumonitis in a patient with non-small cell lung cancer. This case emphasizes the importance of considering radiation recall pneumonitis in the differential diagnosis of lung consolidation during immunotherapy and suggests that it may anticipate more extensive immune-checkpoint inhibitor-induced pneumonitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Bing Li, Xiaoli Zheng, Jiang Zhang, Saikit Lam, Wei Guo, Yunhan Wang, Sunan Cui, Xinzhi Teng, Yuanpeng Zhang, Zongrui Ma, Ta Zhou, Zhaoyang Lou, Lingguang Meng, Hong Ge, Jing Cai
Summary: The study evaluates the effectiveness of features obtained from proposed incremental-dose-interval-based lung subregion segmentation for predicting grade >= 2 acute radiation pneumonitis (ARP) in lung cancer patients. Results show that features from lung subregions outperform those from the whole lung in predicting ARP, especially when using dosiomics or combined radiomics-dosiomics features. This improved model performance could enhance clinical management and patient quality of life.
Article
Pharmacology & Pharmacy
Bing Li, Ge Ren, Wei Guo, Jiang Zhang, Sai-Kit Lam, Xiaoli Zheng, Xinzhi Teng, Yunhan Wang, Yang Yang, Qinfu Dan, Lingguang Meng, Zongrui Ma, Chen Cheng, Hongyan Tao, Hongchang Lei, Jing Cai, Hong Ge
Summary: This study investigates the impact of lung function on radiation pneumonitis prediction using a dual-omics analysis method, and finds that dual-omics features from different lung functional regions can improve the prediction of radiation pneumonitis for lung cancer patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Animesh Saha, Matthew Beasley, Nathaniel Hatton, Peter Dickinson, Kevin Franks, Katy Clarke, Pooja Jain, Mark Teo, Patrick Murray, John Lilley
Summary: In patients treated with SABR for early-stage lung cancer, factors such as tumor location, size, PTV, mean lung dose, etc., need to be considered to predict symptomatic radiation pneumonitis.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Janita E. van Timmeren, Stefanie Ehrbar, Madalyne Chamberlain, Michael Mayinger, Mischa S. Hoogeman, Nicolaus Andratschke, Matthias Guckenberger, Stephanie Tanadini-Lang
Summary: A single-isocenter SBRT technique for lung patients with multiple targets results in clinically acceptable increases in normal lung dose.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Marek Konkol, Maciej Bryl, Marek Fechner, Krzysztof Matuszewski, Pawel Sniatala, Piotr Milecki
Summary: Radiation-induced lung injury is a significant toxicity in thoracic radiotherapy. This study aimed to establish a quantitative grading method by analyzing the changes in lung tissue density using CT scans. The results confirmed a dose-response effect and identified clinical factors that correlated with the degree of lung injury.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hwa Kyung Park, Chang-Seok Yoon, Young-Ok Na, Jae-Kyeong Lee, Hyung-Joo Oh, Ha-Young Park, Bo-Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Yong-Soo Kwon, In-Jae Oh, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, Cheol-Kyu Park
Summary: This study confirms the feasibility of serum KL-6 as a potential biomarker for evaluating and predicting TR-ILD. High levels of KL-6 are associated with severe TR-ILD and can be used to exclude severe TR-ILD. Serum KL-6 levels are also correlated with patient survival.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Min Wang, Shuhui Xu, Hui Zhu
Summary: This report presents a rare case of double pneumonitis (RP and RRP) in a patient with non-small lung cancer (NSCLC), with RP occurring at 3 months and RRP induced by anti-PD-1 sintilimab at 10 months after radiotherapy. This case draws attention to the identification of immune or radiation pneumonitis, its potential mechanism, and the treatment strategy for RRP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Daisuke Kawahara, Nobuki Imano, Riku Nishioka, Yasushi Nagata
Summary: This study proposes a prediction model using a convolutional neural network (CNN) model with image cropping to predict the severity of radiation pneumonitis (RP) in non-small-cell lung cancer (NSCLC) patients after radiotherapy. The CNN model uses 3D computed tomography (CT) images, cropped in different regions, as input data to classify patients into RP grade < 2 or RP grade >= 2. The performance of the model is evaluated using sensitivity, specificity, accuracy, and area under the curve (AUC) measures, with the nLung boolean AND 20 Gy method achieving the highest accuracy, specificity, sensitivity, and AUC.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Article
Oncology
Janna Berg, Christina Ramberg, Jon Olav Sulheim Haugstvedt, May-Bente Bengtson, Anne-Marie Gabrielsen, Odd Terje Brustugun, Ann Rita Halvorsen, Aslaug Helland
Summary: This study investigated changes in pulmonary function, symptoms, and radiological signs of pneumonitis in patients receiving stereotactic body radiation therapy for early-stage non-small cell lung cancer. Symptomatic radiation pneumonitis occurred in 18% of patients, while asymptomatic pneumonitis was observed in 39% based on radiology. Early decreases in FEV1 and DLCO may indicate the development of symptomatic radiation pneumonitis, which could be predicted by doses to critical lung volumes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Respiratory System
Marisol Arroyo-Hernandez, Federico Maldonado, Francisco Lozano-Ruiz, Wendy Munoz-Montano, Monica Nunez-Baez, Oscar Arrieta
Summary: Pneumonitis, including Radiation Pneumonitis and Radiation Fibrosis, can be life-threatening adverse pulmonary effects caused by various factors. Pulmonary function tests play a significant role in evaluating lung function status during treatment and preventing complications.
BMC PULMONARY MEDICINE
(2021)
Article
Oncology
Hakyoung Kim, Jeongeun Hwang, Sun Myung Kim, Juwhan Choi, Dae Sik Yang
Summary: This study identified idiopathic pulmonary fibrosis as an underlying lung disease and the concurrent use of chemotherapy as risk factors for the development of severe radiation pneumonitis in patients with non-small cell lung cancer treated with curative high-dose radiotherapy.
Article
Oncology
Elisabetta Parisi, Donatella Arpa, Giulia Ghigi, Lucia Fabbri, Flavia Foca, Luca Tontini, Elisa Neri, Martina Pieri, Simona Cima, Marco Angelo Burgio, Maria Luisa Belli, Luca Luzzi, Antonino Romeo
Summary: This publication presents preliminary toxicity results of a phase II trial using accelerated hypofractionated radiotherapy in 20 patients with pleural mesothelioma. The treatment showed no severe acute or late toxicity, with pneumonitis being the most common acute toxicity. The median overall survival was 33.1 months and the median time to progression was 18.2 months, indicating encouraging results for this treatment approach.
