Stereotactic radiotherapy for lung cancer: Non-invasive real-time tumor tracking

Purpose. - Stereotactic radiation therapy using the CyberKnife (R) has been introduced in France in 2006. Two treatment modalities are currently available: the first one (Synchrony (R)) is a real-time fiducial-based target tracking system, while the other (Xsight Lung Tracking [XLT] System (R)) is completely fiducial-free. Patients and methods. - Sixty-eight patients were treated for a pulmonary tumor between June 2007 and November 2009. Since august 2008, the XLT System (R) was used for 26 patients. We report the necessary conditions for the XLT System (position, laterality and size of the tumor), the toxicity and outcome of this treatment. Results. - Twenty-two patients were analyzed. Median follow-up was 6 months (min = 3; max = 6). Local control rate was 100%. The main toxicity was grade grade 1 pulmonary alveolitis (27%). No grade 3 or 4 toxicities were reported. Conclusion. - The high local control rate and low toxicity obtained with the CyberKnife (R) XLT System (R) suggest that such treatment is an alternative for inoperable patients. () 2010 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.