Journal
CANCER LETTERS
Volume 345, Issue 1, Pages 39-47Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.11.023
Keywords
MicroRNA miR-302; Ishikawa cells; HEC-1-B cells; G2/M phase
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Funding
- National Natural Science Foundation of China [30900847]
- Chinese National 973 Projects [2010CB945104]
- Health Innovation Team Project of Jiangsu Province [LJ201102]
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MicroRNA miR-302 has been found to induce some tumor cell lines to transdifferentiate into miRNA-induced pluripotent stem cells (mirPS), thereby inhibiting tumor cell proliferation and reducing tumorigenicity. This study firstly found that miR-302 inhibited the proliferation and migration of endometrial cell line, Ishikawa and HEC-1-B, and arrested cell cycle at the G2/M phase. In addition, miR-302 inhibited tumorigenicity in immunodeficient mice transplanted with Ishikawa cells. Microarray and Western blotting results showed that miR-302 significantly inhibited CDK1 and Cyclin D1 gene expression in Ishikawa cells. MiR-302 directly targeted Cyclin D1, but indirectly regulated CDK1 gene expression. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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