Journal
CANCER LETTERS
Volume 344, Issue 1, Pages 90-100Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.10.014
Keywords
Antiestrogen resistance; Breast cancer; Fulvestrant; HER2; c-Src
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Funding
- Danish Cancer Society
- Aase and Ejnar Danielsen foundation
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In this study, T47D cell lines resistant to the antiestrogen fulvestrant were established and analyzed to explore, whether a switch to HER signaling, as seen in fulvestrant resistant MCF-7 cell lines, is a general resistance mechanism. We find that parental T47D cells depend on ER and HER signaling for growth. Fulvestrant resistant T47D cells have lost ER expression and, although HER2 was over expressed, growth was only partially driven by HER receptors. Instead c-Src was important for resistant growth. Thus, the T47D and MCF-7 model system unravel different resistance mechanisms which may be important for fulvestrant resistant breast cancer patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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