Review
Pharmacology & Pharmacy
Zhenwei Su, Shaowei Dong, Shan-Chao Zhao, Kaisheng Liu, Yao Tan, Xingyu Jiang, Yehuda G. Assaraf, Bo Qin, Zhe-Sheng Chen, Chang Zou
Summary: Chemotherapy is powerful in eliminating malignant cells, but its efficacy is often hindered by drug resistance. Nanomedicine, focusing on targeted drug delivery to tumor tissues using nano-sized formulations, shows promise in improving treatment outcomes, minimizing adverse effects, and overcoming cancer drug resistance. This approach involves strategies such as passive and active targeted delivery, delivering multidrug combinations, and multimodal combination therapy to pave the way for effective cancer treatment and holds great potential in overcoming drug resistance.
DRUG RESISTANCE UPDATES
(2021)
Review
Nanoscience & Nanotechnology
Hong Tan, Mengyu Zhang, Yuqing Wang, Peter Timashev, Yuanyuan Zhang, Shouwen Zhang, Xing-Jie Liang, Fangzhou Li
Summary: Tumor multidrug resistance is a major cause of clinical chemotherapy failure, and nanotechnology offers various strategies to overcome this issue. Further research is needed to explore the mechanisms of drug endocytosis and fate.
Article
Pharmacology & Pharmacy
Yuval Bin Kanner, Qiu-Xu Teng, Assaf Ganoth, Dan Peer, Jing-Quan Wang, Zhe-Sheng Chen, Yossi Tsfadia
Summary: This study aimed to investigate whether three antidepressant drugs from the SSRI family could be repurposed as inhibitors of MRP1 and MRP7 transporters and reverse multidrug resistance in cancer cells. The results show that these drugs exhibited inhibitory/reversal effects on both MRP1-overexpressed cells and MRP7-overexpressed cells in the presence of chemotherapies, suggesting their potential in targeting multidrug resistance in cancer cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Johana Eyzaguirre-Velasquez, Maria Paz Gonzalez-Toro, Camila Gonzalez-Arancibia, Jorge Escobar-Luna, Caroll J. Beltran, Javier A. Bravo, Marcela Julio-Pieper
Summary: The study showed that sertraline increased transepithelial electrical resistance in the rat colon, while citalopram prevented the increase in phospho-IRF3 protein, a marker of TLR-3 activation, in the LP-rat ileum. These findings suggest that sertraline could be a potential therapeutic strategy for protecting intestinal barrier function in life-threatening situations or chronic conditions associated with gut epithelial disruption.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Polymer Science
Tjasa Gornik, Sudhirkumar Shinde, Lea Lamovsek, Maja Koblar, Ester Heath, Borje Sellergren, Tina Kosjek
Summary: This study demonstrated the potential of molecularly imprinted polymers as sorbents for removing SSRIs in water treatment, with optimized composition to achieve highest capacity, affinity, and selectivity. The MIPs showed stable performance, reusability, and superior sorption capabilities in wastewaters, making them better suited for use in wastewater treatment.
Article
Clinical Neurology
Jeffrey R. Strawn, Jeffrey A. Mills, Vikram Suresh, Tara S. Peris, John T. Walkup, Paul E. Croarkin
Summary: The combination of a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy (CBT) has been shown to be more effective in treating depression and anxiety disorders in children and adolescents. The added value of CBT becomes more significant as treatment progresses, and this approach is robust across a variety of patient characteristics.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Clinical Neurology
Isabella Stuckart, Timo Siepmann, Christian Hartmann, Lars-Peder Pallesen, Annahita Sedghi, Jessica Barlinn, Heinz Reichmann, Volker Puetz, Kristian Barlinn
Summary: In acute ischemic stroke patients, early treatment with sertraline may contribute to improved functional recovery. Patients in the sertraline group showed worse neurological scores at baseline, but had a higher rate of favorable functional outcomes at 3 months and lower incidence of incident depression compared to the control group.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Gianni Frascotti, Elisabetta Galbiati, Matteo Mazzucchelli, Maria Pozzi, Lucia Salvioni, Jacopo Vertemara, Paolo Tortora
Summary: The vault nanoparticle is a eukaryotic ribonucleoprotein complex consisting of 78 individual 97 kDa-major vault protein (MVP) molecules that form two symmetrical, cup-shaped, hollow halves. It plays diverse cellular functions including protection against cellular stresses and activation of prosurvival signaling pathways. Its biological roles in physiological and pathological processes may provide new insights for its utilization as a nanocarrier for drug delivery.
Article
Oncology
Vincent Pautu, Elise Lepeltier, Adelie Mellinger, Jeremie Riou, Antoine Debuigne, Christine Jerome, Nicolas Clere, Catherine Passirani
Summary: Response rates to new commercialized therapies are low in metastatic melanoma patients, in part due to the development of multidrug resistance (MDR). Research has shown that modifying lipid nanoparticles (LNC) with pH-responsive properties can improve cellular uptake under acidic conditions, making them promising nanocarriers for targeting metastatic melanoma.
Article
Oncology
Ping Tan, Xiaoting Chen, Hu Zhang, Qiang Wei, Kui Luo
Summary: In the past decade, nanomedicine has seen unprecedented development in disease diagnosis and treatment. Several nanomedicines have been approved for clinical use, demonstrating the potential value of transitioning nanotechnology-modified medicines from the lab to the bedside. The application of artificial intelligence (AI) in the development of nanotechnology-based products has the potential to transform healthcare by enabling the acquisition and analysis of large datasets and tailoring precision nanomedicines for cancer management.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Clinical Neurology
Busra Yildiz Bayindir, Ali Karayagmurlu
Summary: Sertraline is a safe and effective medication commonly used for childhood depression and OCD, but may lead to amotivational syndrome. This report discusses a case of a 12-year-old girl who developed amotivational syndrome while on sertraline therapy, and successfully managed the side effect by switching to fluoxetine.
CLINICAL NEUROPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Edyta Barnas, Elzbieta Ostanska, Dorota Bartusik-Aebisher, Klaudia Dynarowicz, Joanna Skret-Magierlo, David Aebisher
Summary: Breast cancer is commonly treated with surgery and adjuvant chemotherapy or radiotherapy, but these methods have limitations such as high risk and drug resistance. Combining chemotherapy with photodynamic therapy has shown improved therapeutic effects against multidrug-resistant cancer cells, with potential benefits from nano medicine.
ACTA POLONIAE PHARMACEUTICA
(2021)
Review
Pharmacology & Pharmacy
Kimberley M. Hanssen, Michelle Haber, Jamie Fletcher
Summary: The article discusses various therapeutic strategies targeting ABC transporters, including the development of small molecule inhibitors, exploiting collateral sensitivity to glutathione depletion and ferroptosis, gene silencing, and modulation of transporter activity by new molecules. These new approaches show promise beyond simple MDR reversal and provide exciting avenues for further research.
DRUG RESISTANCE UPDATES
(2021)
Review
Biotechnology & Applied Microbiology
Wencheng Wu, Yinying Pu, Jianlin Shi
Summary: Nanomedicine provides alternative and promising approaches for cancer therapy, with nanocatalytic medicine capable of generating toxic substances within tumors without relying on highly toxic non-selective chemotherapeutic agents. Nanomedicine also serves as a versatile platform for integrating different treatment modalities with chemotherapy to achieve synergistic tumor treatments.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Uri Elia, Shahar Rotem, Erez Bar-Haim, Srinivas Ramishetti, Gonna Somu Naidu, David Gur, Moshe Aftalion, Ma'ayan Israeli, Adi Bercovich-Kinori, Ron Alcalay, Efi Makdasi, Theodor Chitlaru, Ronit Rosenfeld, Tomer Israely, Sharon Melamed, Inbal Abutbul Ionita, Dganit Danino, Dan Peer, Ofer Cohen
Summary: The COVID-19 pandemic led to the development of mRNA vaccines, and a recent study demonstrated that an RBD-hFc mRNA vaccine could provide protection against lethal SARS-CoV-2 infection in mice expressing human ACE2. The vaccinated mice showed robust humoral responses and 70% of them survived the lethal virus challenge, while all control animals succumbed to infection.
Article
Chemistry, Multidisciplinary
Seok-Beom Yong, Srinivas Ramishetti, Meir Goldsmith, Yael Diesendruck, Inbal Hazan-Halevy, Sushmita Chatterjee, Gonna Somu Naidu, Assaf Ezra, Dan Peer
Summary: Chemo-immunotherapy is an advanced therapeutic modality for cancer treatment, but many patients still respond poorly to it. This study developed a dual targeted HO1-inhibiting lipid nanotherapeutic that sensitizes cancer cells to chemotherapy and improves the responsiveness to immune checkpoint inhibitor therapy by reprogramming tumor myeloid cells.
ADVANCED MATERIALS
(2022)
Review
Biochemical Research Methods
Edo Kon, Uri Elia, Dan Peer
Summary: mRNA lipid nanoparticles (LNPs) have gained significant attention as therapeutic platforms due to the success of the SARS-CoV-2 mRNA LNP vaccines. The modularity and rapid manufacturing capabilities are the advantages of mRNA-LNP vaccines. When designing optimal mRNA-LNPs, choices regarding efficacy, stability, and toxicity need to be made.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dana Tarab-Ravski, Lior Stotsky-Oterin, Dan Peer
Summary: This article introduces the current successful strategies for delivering therapeutic RNA to leukocytes and discusses their potential clinical applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Maria Poley, Patricia Mora-Raimundo, Yael Shammai, Maya Kaduri, Lilach Koren, Omer Adir, Jeny Shklover, Janna Shainsky-Roitman, Srinivas Ramishetti, Francis Man, Rafael T. M. de Rosales, Assaf Zinger, Dan Peer, Irit Ben-Aharon, Avi Schroeder
Summary: Physiological changes in the female menstrual cycle impact the biodistribution of nanoparticles in the reproductive system, which has significant implications for treatment.
Article
Biochemistry & Molecular Biology
Olga Karpov, Meir Lahav, Ofir Wolach, Pia Raanani, Dan Peer, Tal Kaplan, Orit Uziel
Summary: Early detection of tumor cells by identifying universal tumor associated antigens has significant implications. Human Telomerase Reverse Transcriptase (hTERT) is a potential candidate for optimal tumor associated antigen. A monoclonal antibody against hTERT peptide has been developed and shows potential applications as a pan-cancer marker. Liquid biopsies, a noninvasive tool in precision oncology, can overcome limitations associated with tissue biopsies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Bram Bogaert, Felix Sauvage, Roberta Guagliardo, Cristina Muntean, Van Phuc Nguyen, Eline Pottie, Mike Wels, An-Katrien Minnaert, Riet De Rycke, Qiangbing Yang, Dan Peer, Niek Sanders, Katrien Remaut, Yannis M. Paulus, Christophe Stove, Stefaan C. De Smedt, Koen Raemdonck
Summary: With the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics has gained widespread acceptance. Researchers have developed a novel type of lipid-based nanocarrier called CADosomes, which can efficiently deliver mRNA to target cells and have shown promising results in both in vitro and in vivo studies. This versatile and straightforward approach has the potential to revolutionize drug combination therapies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Xiangang Huang, Edo Kon, Xuexiang Han, Xingcai Zhang, Na Kong, Michael J. Mitchell, Dan Peer, Wei Tao
Summary: This Perspective explores the potential role of nanotechnology in addressing the rise of new SARS-CoV-2 variants. Nanotechnology has been instrumental in the fight against SARS-CoV-2, particularly with the development of highly effective nanotechnology-based mRNA vaccines. However, the emergence of new variants has hindered efforts to bring an end to the pandemic, necessitating the proposal of novel strategies to tackle the crisis posed by existing and emerging SARS-CoV-2 variants.
NATURE NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nuphar Veiga, Yael Diesendruck, Dan Peer
Summary: Designing a therapeutic modality with specific delivery to certain organs, tissues, or cell types is essential for efficient treatment and minimizing off-target side effects. Nanoparticles loaded with various drugs have emerged as a promising approach to achieve this goal. However, successful targeted delivery requires overcoming multiple biological barriers, such as systemic distribution, tissue penetration, and intracellular trafficking. Recent advances in understanding these barriers and functionalizing nanoparticles with targeting moieties have shown tremendous progress. Implementing new approaches like multi-functionalized nanocarriers and machine learning models can further enhance the design of safe and cell-specific nanoparticle delivery systems. This review critically examines the current progress in the field and proposes novel strategies to improve cell-specific delivery of therapeutic payloads.
JOURNAL OF CONTROLLED RELEASE
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Dan Peer
Editorial Material
Biotechnology & Applied Microbiology
Uri Elia, Edo Kon, Dan Peer
Summary: Improved lipid nanoparticles are used to deliver CRISPR RNA to the mouse lung via inhalation.
NATURE BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Dor Breier, Dan Peer
Summary: Since its discovery in 2012, the CRISPR/Cas9 system has revolutionized genome editing and shown potential as a therapy for genetic diseases and cancer. However, there are challenges to be addressed before clinical testing, including the safety of in-vivo therapies and effects on genomic stability.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Joke Deprez, Rein Verbeke, Sofie Meulewaeter, Ilke Aernout, Heleen Dewitte, Tine Decruy, Julie Coudenys, Julie Van Duyse, Gert Van Isterdael, Dan Peer, Roy van der Meel, Stefaan C. C. De Smedt, Peggy Jacques, Dirk Elewaut, Ine Lentacker
Summary: The therapeutic potential of liposomes for drug delivery to inflamed tissue is well-established. The main mechanism of liposomal transport into inflamed joints is believed to be selective extravasation through endothelial gaps at inflammatory sites, known as the enhanced permeation and retention effect. However, the role of blood-circulating myeloid cells in liposome uptake and delivery has been largely overlooked. A study using a collagen-induced arthritis model demonstrates that myeloid cells can transport liposomes to inflammatory sites, and their depletion significantly reduces liposomal accumulation. Contrary to the prevailing theory, the long circulation times of PEGylated liposomes actually favor uptake by myeloid cells, challenging the current understanding of synovial liposomal accumulation and highlighting the potential for alternative delivery pathways in inflammatory diseases.
NATURE NANOTECHNOLOGY
(2023)
Review
Oncology
Edo Kon, Nitay Ad-El, Inbal Hazan-Halevy, Lior Stotsky-Oterin, Dan Peer
Summary: In oncology, mRNA-lipid nanoparticles (LNPs) have been used either to achieve intratumoural expression of immune-stimulating cytokine combinations or as cancer vaccines, and new strategies are in development to enable the selective delivery of payloads into cancer cells previously considered unreachable. The authors of this Review present various approaches for delivering mRNA-LNPs to tumours and discuss improvements that will improve the selective targeting of cancer cells with mRNA-LNPs.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
A. Brosque, L. Russo-Noori, D. Tarab, A. Gutkin, D. Peer, D. Friedmann-Morvinski
HUMAN GENE THERAPY
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.