Article
Oncology
Enrico Capobianco, Vanessa McGaughey, Gerbenn Seraphin, John Heckel, Sandra Rieger, Thomas S. S. Lisse
Summary: Vitamin D and its receptor play an important role in inhibiting osteosarcoma metastasis and growth by regulating NMD-ROS-EMT signaling. This study reveals that vitamin D can inhibit the progression of osteosarcoma by suppressing the EMT pathway and exert its anti-tumor effects by regulating the NMD machinery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Baojin Wang, Hanxuan Li, Xinxin Zhao, Wenjing Zhang, Guannan Zhao, Zhongzhi Wu, Ruitao Zhang, Peixin Dong, Hidemichi Watari, Gabor Tigyi, Wei Li, Junming Yue
Summary: This study demonstrated that a new analog HL142 can reverse EMT in ovarian cancer cells by inhibiting the interaction of ASAP1 and FAK, leading to decreased proliferation, migration, and invasion while promoting the expression of epithelial markers. HL142 also showed sensitivity to chemotherapy drug and inhibited tumor growth and metastasis in orthotopic OC mouse models by attenuating the TGF beta and FAK pathways both in vitro and in vivo.
Article
Oncology
Elise Pretzsch, Volker Heinemann, Sebastian Stintzing, Andreas Bender, Shuo Chen, Julian Walter Holch, Felix Oliver Hofmann, Haoyu Ren, Florian Boesch, Helmut Kuechenhoff, Jens Werner, Martin Konrad Angele
Summary: Despite advances in therapy, the survival rate for metastatic colorectal cancer (CRC) patients remains low. Proper risk stratification is necessary to avoid inadequate or excessive treatment. This study analyzed the prognostic effect of EMT-related genes in stage IV CRC patients and found that their prognostic relevance may depend on the stage of cancer.
Review
Chemistry, Medicinal
Jul Dardare, Andrea Witz, Jean-Louis Merlin, Agathe Bochnakian, Paul Toussaint, Pauline Gilson, Alexandre Harle
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late-stage diagnosis. EMT plays a significant role in PDAC, not only related to cancer progression and metastasis, but also potentially becoming a new therapeutic target.
Article
Oncology
Zhihui Wen, Jingbo Sun, Junjie Luo, Yun Fu, Yue Qiu, Yanyan Li, Yangwei Xu, Hongmei Wu, Qingling Zhang
Summary: The high expression of COL10A1 in pancreatic cancer cells and tissues is associated with poor prognosis and clinicopathological features. COL10A1 regulates PDAC cell proliferation and MEK/ERK signaling pathways by binding to DDR2, promoting migration, invasion, and EMT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Min-Woo Nam, Hong Kyu Lee, Cho -Won Kim, Youngdong Choi, Dohee Ahn, Ryeo-Eun Go, Kyung-Chul Choi
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type that is resistant to conventional treatments. This study investigated the role of CCN6 in PDAC and found that CCN6 promotes cell viability and tumorigenesis, as well as enhances metastatic potential through the p38 MAPK and BMPs signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Ke Xue, Huilin Zheng, Xiaowen Qian, Zheng Chen, Yangjun Gu, Zhenhua Hu, Lei Zhang, Jian Wan
Summary: By analyzing data from metastatic pancreatic cancer samples and cell lines, this study identified six genes associated with metastasis risk and constructed a risk-scoring model. The risk score based on the expression of these genes could better predict the risk of metastasis and serve as an important predictor for pancreatic cancer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Tuan Luu
Summary: Pancreatic cancer, known for its high mortality and insensitivity to existing therapies, has attracted increasing scholarly attention for its progression mechanisms, particularly the role of epithelial-mesenchymal transition (EMT) in cancer genesis and metastasis. Recent discoveries on EMT-regulating factors in pancreatic cancer have shed light on the relationship between EMT and this cancer type, marking a key advancement in research on EMT in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Fei Cai, Cheng Hu, Chan-Juan Chen, Yuan-Ping Han, Zi-Qi Lin, Li-Hui Deng, Qing Xia
Summary: Vitamin D metabolic disorder is implicated in both acute and chronic pancreatitis, with studies showing its anti-inflammatory and anti-fibrotic effects through binding with VDR. Further research is needed to establish the protective role of vitamin D in pancreatitis, but current evidence suggests that assessing and supplementing vitamin D levels are important strategies for management.
Article
Biochemistry & Molecular Biology
Qian Ji, Hengchao Li, Zhiwei Cai, Xiao Yuan, Xi Pu, Yumeng Huang, Shengqiao Fu, Liangmei Chu, Chongyi Jiang, Junli Xue, Xiaoxin Zhang, Rongkun Li
Summary: Bioinformatics analyses identified glycogen phosphorylase L (PYGL) as a key regulator of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC). PYGL overexpression promotes PDAC cell migration and invasion, while PYGL knockdown has opposite effects. Hypoxia induces PYGL expression in a HIF1 alpha-dependent manner and regulates glycogen accumulation to fuel glycolysis, thereby inducing the EMT process. Clinically, elevated PYGL expression is associated with poor prognosis in PDAC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kazuhisa Kitami, Masato Yoshihara, Satoshi Tamauchi, Mai Sugiyama, Yoshihiro Koya, Yoshihiko Yamakita, Hiroki Fujimoto, Shohei Iyoshi, Kaname Uno, Kazumasa Mogi, Yoshiki Ikeda, Akira Yokoi, Nobuhisa Yoshikawa, Kimihiro Nishino, Kaoru Niimi, Akihiro Nawa, Atsushi Enomoto, Hiroaki Kajiyama
Summary: The study found that vitamin D inhibited the transformation of ovarian cancer cells into mesothelial cells and restored the normal state of mesothelial cells, thereby suppressing ovarian cancer dissemination. Vitamin D suppressed thrombospondin-1 expression by competing with Smad3, which played a significant role in preventing ovarian cancer dissemination.
Article
Oncology
Estefania Carrasco-Garcia, Lidia Lopez, Veronica Moncho-Amor, Fernando Carazo, Paula Aldaz, Manuel Collado, Donald Bell, Ayman Gaafar, Eva Karamitopoulou, Alexandar Tzankov, Manuel Hidalgo, Angel Rubio, Manuel Serrano, Charles H. Lawrie, Robin Lovell-Badge, Ander Matheu
Summary: The study shows that SOX9 plays a crucial role in the progression and metastasis of pancreatic cancer by regulating stemness and EMT processes. High levels of SOX9 are associated with metastases in clinical samples.
Article
Oncology
Fang-Jing Zhong, Bo Sun, Mo-Mo Cao, Cong Xu, Yi-Ming Li, Lian-Yue Yang
Summary: Metastasis is a major challenge in improving survival for HCC patients, with EMT playing a critical role. STMN2, a regulator of MT dynamics, is up-regulated in HCC and correlates with aggressive clinicopathological features and poor prognosis. STMN2 orchestrates MT disassembly to facilitate EMT via TGF-beta signaling, providing new insights into cancer metastasis mechanisms.
Article
Biochemistry & Molecular Biology
Barbara Wojcik, Ewa Sawosz, Jaroslaw Szczepaniak, Barbara Strojny, Malwina Sosnowska, Karolina Daniluk, Marlena Zielinska-Gorska, Jasmina Balaban, Andre Chwalibog, Mateusz Wierzbicki
Summary: Pancreatic cancer is difficult to cure due to its asymptomatic development and drug resistance. This study evaluated the toxic properties of various nanomaterials against human pancreatic adenocarcinoma cell lines, revealing diamond as the most cytotoxic material. Graphene oxide and diamond had different effects on pro-inflammatory proteins levels in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang
Summary: This study found that EGR1 is highly expressed in pancreatic cancer and is associated with prognosis and cancer metastasis. EGR1 promotes migration and invasion ability of pancreatic cancer cells and is correlated with the epithelial-mesenchymal transition process. The study also revealed that EGR1 activates the SNAI2 gene through interaction with p300/CBP. In vivo experiments confirmed that EGR1 promotes liver metastasis of pancreatic cancer. Therefore, blocking the expression of EGR1 could be a new anticancer strategy for pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chi-Jen Tai, Chih-Hua Chao, Atallah F. Ahmed, Chia-Hung Yen, Tsong-Long Hwang, Fang-Rong Chang, Yusheng M. Huang, Jyh-Horng Sheu
Summary: Chemical investigation of the Red Sea sponge Spongia sp. resulted in the discovery of four new compounds, secodinorspongins A-D (1-4), as well as a known compound sponginolide (5). The structures of these compounds and their absolute configurations were elucidated using spectroscopic methods and a comparison of calculated and experimental CD spectra. A possible biosynthetic pathway for compounds 1-4 was proposed. The cytotoxic, antibacterial, and anti-inflammatory activities of compounds 1-5 were also evaluated, with compound 1 showing inhibitory activity against Staphylococcus aureus growth, and compounds 4 and 5 suppressing superoxide-anion generation and elastase release in human neutrophils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
I-Ting Wu, Yu-Chen Fan, Guan-Zhou Lin, Yi-Lin Wang, Tsong-Long Hwang, Kuei-Hung Lai, Hsu -Ming Chung
Summary: Chemical investigations on the ethyl acetate extract of the octocoral Capnella imbricata collected from the waters of Taiwan led to the isolation of three capnellenes, including one new metabolite. The structures and relative stereochemistry of the isolated metabolites were determined through extensive spectroscopic analyses and X-ray diffraction analysis. The anti-inflammatory activity of compounds 1-3 was evaluated by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H. Abadi
Summary: PDE5 inhibitors have anticancer effects and cGMP elevation plays a role in CRC. We synthesized 31 derivatives of 9-benzylaminoacridine and found 22 of them showed micromolar or sub-micromolar inhibition against PDE5. Compounds 11, 12, and 28 exhibited significant growth inhibition, superior Topo II inhibitory activity, low micromolar PDE5 inhibition, and affected cell cycle progression in HCT-116 CRC cells. These compounds have potential as effective therapeutic agents against cancer.
Article
Food Science & Technology
Yu-Li Chen, Chun-Yu Chen, Kuei-Hung Lai, Yu-Chia Chang, Tsong-Long Hwang
Summary: This study found that flavone C-glycosides in Lophatherum gracile are the main active components with anti-inflammatory and antiviral effects. They developed a simple chromatography-based method to extract flavone C-glycoside-enriched extract and demonstrated its ability to inhibit respiratory bursts and neutrophil extracellular trap formation. Additionally, the extract was shown to inhibit SARS-CoV-2 pseudovirus infection by interfering with the binding of the spike protein to ACE2.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, General & Internal
Shu-Chuan Weng, Shu-Han Tsao, Han-Yu Tsai, Horng-Heng Juang, Yu-Hsiang Lin, Phei-Lang Chang, Chien-Lun Chen, Chen-Pang Hou
Summary: Bleeding during endoscopic prostate surgery is often overlooked, but we proposed a simple method to assess its severity. Our research revealed that using the thulium laser, patients over 80 years old, and those with a preoperative Qmax of more than 10 cc/s experienced less bleeding. The severity of bleeding affected the treatment outcomes, with patients experiencing less severe bleeding having easier tissue enucleation and better postoperative outcomes.
Article
Plant Sciences
Tzu-Yi Ke, Shih-Wei Wang, Shu-Rong Chen, Dong-Ming Huang, Yun-Sheng Lin, Tsong-Long Hwang, Wen-Chun Sun, Yuan-Bin Cheng
Summary: Four new alkaloids and three new polyacetylenes were isolated from Hippobroma longiflora. The structures of the compounds were determined using mass and NMR spectroscopic data, as well as X-ray and ECD analyses. The compounds exhibited weak antiangiogenic activity against human endothelial progenitor cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Te-An Kung, Lo-Yun Chen, Chia-Ying Li, Bo-Rong Peng, Tsong-Long Hwang, Ping-Jyun Sung, Kuei-Hung Lai, Hsu -Ming Chung
Summary: Two new compounds, querciformolide G (1) and H (2), along with three known compounds, sinulaparvalide (3), sinulariolone acetate (4), and 3,4:8,11-bisepoxy-7-hydrox-ycembra-15(17)-en-1,12-olide (5), were discovered during the exploration of Sinularia querciformis cembranoids. The structures of these compounds were determined through extensive spectroscopic analysis and comparison with previously reported compounds. The anti-inflammatory activity of compounds 1-5 was evaluated, and compound 1 exhibited significant inhibitory effects on elastase release in activated human neutrophils.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Cell Biology
Ching-Hui Tsai, Alan Chuan-Ying Lai, Yu-Cheng Lin, Po-Yu Chi, Yun-Chi Chen, Yao-Hsu Yang, Chien-Han Chen, Sheng-Yeh Shen, Tsong-Lon Hwang, Ming-Wei Su, I-Ling Hsu, Yu-Chi Huang, Anke H. Maitland-van der Zee, Michael J. McGeachie, Kelan G. Tantisira, Ya-Jen Chang, Yungling L. Lee
Summary: The association between neutrophil extracellular traps (NETs) and response to inhaled corticosteroids (ICS) in asthma was investigated. It was found that neutrophils play a potential role in uncontrolled asthma, and NET abundance is associated with nonresponse to ICS. Furthermore, CCL4L2 was identified as a potential therapeutic target for individuals with asthma refractory to ICS.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Ngoc Bao An Nguyen, Mohamed El-Shazly, Po-Jen Chen, Bo-Rong Peng, Lo-Yun Chen, Tsong-Long Hwang, Kuei-Hung Lai
Summary: Inflammation is a crucial defense mechanism, but its exaggerated or uncontrollable response can be detrimental. Regulating inflammation is important to prevent subsequent damage. Neutrophils have been studied extensively in inflammatory diseases, and natural products from octocorals have shown promising anti-inflammatory effects.
Article
Plant Sciences
Chia-Jung Liu, Chien-Chiao Wang, Chun-Feng Chang, Mingzi M. Zhang, Lun Kelvin Tsou, Zhi-Hong Wen, Tsong-Long Hwang, You-Ying Chen, Ping-Jyun Sung
Summary: Two new 16-hydroxybriaranes were isolated from a coral identified as Briareum stechei, and their structures were confirmed through 2D-NMR studies and comparison with literature data. It was found that one of the compounds, briarane 2, could significantly reduce the release of inducible nitric oxide synthase (iNOS) by 87.92% at a concentration of 10 μM.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Plant Sciences
Ju-Hsin Cheng, Ho-Cheng Wu, Chia-Hung Yen, Tsong-Long Hwang, Horng-Huey Ko, Hsun-Shuo Chang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease caused by the accumulation of excess lipids. The research aimed to investigate the bioactive components of Formosan plants that could reduce lipid droplet accumulation. The study found that the methanolic extract of Elaeagnus glabra Thunb. showed excellent anti-LD accumulation activity and isolated several compounds with potential therapeutic effects.
Article
Chemistry, Multidisciplinary
Hieu Tran Trung, Kartiko Arif Purnomo, Szu-Yin Yu, Zih-Jie Yang, Hao-Chun Hu, Tsong-Long Hwang, Nguyen Ngoc Tuan, Le Ngoc Tu, Dau Xuan Duc, Le Dang Quang, Anders Backlund, Tran Dinh Thang, Fang-Rong Chang
Summary: Two new rearranged 2,3-seco-tirucallane triterpenoids, meliadubins A and B, were isolated from the barks of Melia dubia Cav. These compounds exhibited significant anti-inflammatory and antifungal activities.
Article
Urology & Nephrology
Yu-Hsiang Lin, Shin-Yuan Chang, Shu-Han Tsao, Chen-Pang Hou, Chien-Lun Chen, Wen-Chou Lin, Ke-Hung Tsui, Horng-Heng Juang
Summary: This study describes the surgical technique of anterior fibromuscular stroma (AFS)-preserved endoscopic enucleation of the prostate (EEP) for benign prostate obstruction (BOO). The technique can prevent postoperative incontinence and achieves similar surgical outcomes as other methods.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Chemistry, Medicinal
Tsong-Long Hwang, Jing-Yi Lin, Liang-Mou Kuo, Ganesh Kumar Dhandabani, Pei-Wen Hsieh
Summary: The compound 29 showed high inhibitory potency against HNE and dual effects on O2·- generation and elastase release, making it a promising candidate for treating neutrophilic inflammatory diseases.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Letter
Urology & Nephrology
Yu-Hsiang Lin, Ke-Hung Tsui, Horng-Heng Juang
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
