Journal
CANCER LETTERS
Volume 344, Issue 1, Pages 138-146Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.10.025
Keywords
Breast cancer; Metastases; Gene dosage; MLPA
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Funding
- Dutch Cancer Society [UU 2011-5195]
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Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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