Journal
CANCER LETTERS
Volume 328, Issue 1, Pages 160-167Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.08.019
Keywords
Cancer/testis antigen (CTA); Protein microarray; Non-small cell lung cancer (NSCLC); Biomarker
Categories
Funding
- Major State Basic Research Development Program of China [2011CB910704]
- National High Technology Research and Development Program of China [2012AA020206]
- National Natural Science Foundation of China [81172084]
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Cancer/testis antigens (CTAs) are highly immunogenic in many tumors, especially in non-small cell lung cancer (NSCLC). A low-density protein microarray, which consisted of 72 CTAs and six non-CTAs, was used to screen for lung cancer-related autoantibodies. The CIA panel of NY-ESO-1, XAGE-1, ADAM29 and MAGEC1, had sensitivity and specificity values of 33% and 96%, respectively. When examined in a test set, this panel of markers had sensitivity and specificity values of 36% and 89%, respectively. This array of markers preferentially detected NSCLC, but did not detect breast cancer, and non-cancer lung disease. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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