Journal
CANCER LETTERS
Volume 339, Issue 2, Pages 270-278Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.06.025
Keywords
Anterior gradient 2; Oral squamous cell carcinoma; Metastasis; HSC-3
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Funding
- Tissue Bank
- Bioinformatics Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital
- National Science Council [NSC 100-2321-B-006-009-, NSC 101-2321-B-006-008-]
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The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 (agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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