Journal
CANCER LETTERS
Volume 339, Issue 1, Pages 49-59Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.07.023
Keywords
Haematology; Multiple myeloma; Protein folding; ER stress; Hsp70
Categories
Funding
- Cancer Research UK
- Myeloma UK
- NHS
- Cancer Research UK [12573, 12103, 11566] Funding Source: researchfish
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Multiple myeloma (MM) cells rely on protein homeostatic mechanisms for survival. These mechanisms could be therapeutically targeted via modulation of the heat shock response. We studied the roles of Hsp72 and Hsc70, and show that the two major cytoplasmic Hsp70s play a key role in regulating protein homeostasis and controlling multiple oncogenic pathways in MM, and their inhibition can lead to myeloma cell death. Our study provides further evidence that targeting Hsp70 represents a novel therapeutic approach which may be effective in the treatment of MM. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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