Journal
CANCER LETTERS
Volume 335, Issue 2, Pages 447-454Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.03.001
Keywords
Hepatitis B virus; Pancreatic cancer; Chronic pancreatitis
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Funding
- Chinese State Key Project specialized for infectious diseases [2012ZX10002008-002]
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Increasing evidence suggests that a link exists between hepatitis B virus (HBV) serum markers and pancreatic cancer (PC). In this study, HBsAg and HBcAg were expressed in 21.0% (34/162) of PC and 29.0% (47/162) of non-tumor pancreatic tissues, and they were significantly associated with chronic pancreatitis (P = 0.000). The HBV S, C and X genes were identified in 20% (6/30) of PC and 26.9% (7/26) of non-tumor tissues by PCR. A serological survey revealed that the prevalence of HBV DNA and anti-HBc was significantly increased in PC patients compared with healthy controls. Our data suggest that HBV infection in the pancreas may play an etiologic role in PC. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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