Review
Oncology
Seog Young Kang, Dongwon Hwang, Soyoung Shin, Jinju Park, Myoungchan Kim, MD. Hasanur Rahman, Md. Ataur Rahman, Seong-Gyu Ko, Bonglee Kim
Summary: Bioactive food components from natural products play a crucial role in gastric cancer prevention and treatment, with potential mechanisms including suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Administering these natural bioactive food components may enhance the efficacy of gastric chemotherapy and minimize adverse effects, offering potential novel treatment strategies for gastric cancer management.
Article
Pharmacology & Pharmacy
Ali Niapour, Naisana Seyedasli
Summary: This study successfully developed PTX-resistant AGS-R cells, exhibiting resistance to multiple drugs and alterations in key signaling pathways related to survival, EMT, and angiogenesis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shujun Wang, Yiping Wang, Hui Zhu, Miaohui Chen, Liang Zhang
Summary: In this study, it was found that gambogic acid (GA), a natural compound, could inhibit the proliferation of gastric cancer cells by inducing necroptosis, a form of cell death. GA increased the phosphorylation of necroptosis-related proteins and their interactions to form a complex. It also dephosphorylated the effector protein Drp-1. Inhibition of necroptosis and knockdown of PGAM5 attenuated the cell death and proliferation inhibition caused by GA.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yina Qiao, Ting Jin, Shengdong Guan, Shaojie Cheng, Siyang Wen, Huan Zeng, Maojia Zhao, Liping Yang, Xueying Wan, Yuxiang Qiu, Qiao Li, Manran Liu, Yixuan Hou
Summary: The study reveals that Lnc-408 is upregulated in BC cells and enhances invasion and metastasis by regulating LIMK1 expression. Lnc-408 acts as a sponge for miR-654-5p to promote BC invasion through the Lnc-408/miR-654-5p/LIMK1 axis.
Review
Pharmacology & Pharmacy
Shilpi Singh, Abha Meena, Suaib Luqman
Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Xin Qing, Wenjing Xu, Shengli Liu, Zhencheng Chen, Chunping Ye, Yewei Zhang
Summary: This study systematically assessed the association between angiogenesis and gastric cancer (GC). The authors identified two molecular subtypes and determined the correlation between angiogenesis-associated genes mutations, clinicopathological characteristics, prognosis, immune cell infiltration, and tumor microenvironment. They established an AAG_score for predicting overall survival (OS) and created a reliable nomogram for clinical viability. The study provides insights into the characteristics of TME and potential immunotherapy strategies in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chengyu Liu, Hong Chen, Bicheng Hu, Jiajian Shi, Yuchen Chen, Kun Huang
Summary: The widespread clinical use of statins has significantly reduced cardiovascular morbidity and mortality. Dyslipidemia is found to be an important risk factor for cancer, and statins act as powerful inhibitors of HMG-CoA reductase to prevent and intervene in cancer development and enhance sensitivity to anti-cancer drugs. The anti-cancer mechanisms of statins include inhibition of cholesterol biosynthesis and modulation of angiogenesis, apoptosis, autophagy, tumor metastasis, and tumor microenvironment. Clinical studies have shown the therapeutic potentials and feasibility of combining statins with other anti-cancer agents in cancer prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Shifeng Yang, Boshi Sun, Jiacheng Li, Nana Li, Ange Zhang, Xinyu Zhang, Hao Yang, Xiaoming Zou
Summary: Neutrophil extracellular traps (NETs) play a crucial role in promoting angiogenesis in gastric cancer, as confirmed by multiple experiments. These findings provide a theoretical basis for identifying new therapeutic targets for anti-vascular treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Rong Han, Yun Sun, Ruoting Ma, Dexi Wang, Jianan Sun, Shengjun Zhao, Haiying Zhang
Summary: Ferula akitschkensis volatile oil (FAVO) inhibits tumor growth and angiogenesis by suppressing the HIF-2α/VEGF signaling pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhou, Rishun Fu, Mei Yang, Weihuang Liu, Zan Tong
Summary: Lycopene, a natural carotenoid, inhibits the growth and induces apoptosis in gastric cancer cells. It decreases CCNE1 expression and increases the levels of TP53, making it a potential target therapy reagent for gastric cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Shadab Md, Nabil A. Alhakamy, Shahid Karim, Gamal A. Gabr, Mohammad Kashif Iqubal, Samar S. A. Murshid
Summary: Lung cancer is a common and complex disease that presents a significant challenge for treatment. Researchers are exploring various signaling pathways and developing new drugs to target it. MiRNA has emerged as a promising target for lung cancer therapy, but faces challenges such as low stability. Nanocarrier-based drug delivery systems show promise for overcoming limitations and enhancing therapeutic outcomes.
Article
Environmental Sciences
Reza Safavi, Hossein Soltanzadeh, Zahra Hojati
Summary: This study aimed to enhance the therapeutic efficacy of Dox by co-administration of Scr in gastric cancer treatment. The results showed that Scr-Dox combination therapy exerted stronger anti-cancer effects on AGS and MKN28 cell lines, significantly reducing cell proliferation, invasion, and migration, increasing apoptosis rate, and modulating the expression of apoptosis- and metastasis-related genes. In conclusion, Scr-Dox combination therapy is more effective in the treatment of gastric cancer compared to Scr and Dox monotherapy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Hongil Jo, Xinglong Chen, Hee-Seung Lee, Kang Min Ok
Summary: Chirality is a key topic in chemistry due to its unique stereochemical properties and asymmetric structure. Chiral materials may exhibit second-harmonic generation properties, and efficient SHG can be achieved by controlling the arrangement of noncentrosymmetric chromophores.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Seoneun Jeong, Lianjin Zhang, Jaewook Kim, Jintaek Gong, Jonghoon Choi, Kang Min Ok, Yunho Lee, Sunbum Kwon, Hee-Seung Lee
Summary: This study presents the first metal-coordination-mediated assembly of beta-peptide foldamers with 12-helical folding propensity, resulting in unique entangled metal-peptide frameworks. The formation of network structures is accompanied by notable conformational distortions of the foldamer ligands. This work is expected to be an important benchmark for further structural evolution and mechanistic investigation in the field of metal-peptide frameworks.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Taehyung Kim, Se Hun Joo, Jintaek Gong, Sungho Choi, Ju Hong Min, Yongchul Kim, Geunsik Lee, Eunji Lee, Soojin Park, Sang Kyu Kwak, Hee-Seung Lee, Byeong-Su Kim
Summary: In this study, highly crystalline PICs with various pore dimensions were successfully synthesized under geomimetic hydrothermal conditions. The solubility of the oligomeric intermediates under hydrothermal conditions was found to affect the stacking structures of the crystalline PICs. Additionally, the synthesized PICs show promising potential as an anode material in lithium-ion batteries due to their unique redox-active properties and high surface area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Rokam Jeong, Jae-Hoon Eom, Jintaek Gong, Minsang Kang, Jaewook Kim, Hee-Seung Lee
Summary: This study reports the first example of programmed radial assembly of anisotropic microparticles derived from a helical foldamer with a C-terminal cysteine residue. Surface-exposed thiols play a crucial role in facilitating interparticle hydrogen bonding to form higher-order structures in an aqueous solution.
Review
Chemistry, Multidisciplinary
Byeonghoon Choi, Dongwoo Shin, Hee-Seung Lee, Hyunjoon Song
Summary: Metal oxide semiconductors are suitable for chemiresistive gas sensors, with p-type oxide semiconductors being improved through nanostructuring and forming p-n heterojunctions for enhanced sensitivity at low temperatures. These materials are gaining attention as advanced gas sensing materials for environmental and healthcare monitoring, especially when combined with strategies like light activation and sensor arrays for exclusive gas detection at ultra-low concentrations.
Article
Chemistry, Multidisciplinary
Chang-Hee Whang, Jungwoo Hong, Dohyeon Kim, Hong Ryu, Wonsik Jung, Youngju Son, Hyeongseop Keum, Jinjoo Kim, Hocheol Shin, Eugene Moon, Ilkoo Noh, Hee-Seung Lee, Sangyong Jon
Summary: This study reports a library of glycocalyx-mimicking nanoparticles for screening and identification of cancer-targeting nanomedicines. The researchers found that certain nanoparticles selectively targeted different tumors and exhibited potent therapeutic effects. The results suggest that this nanoparticle library has a versatile application potential beyond cancer treatment.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Organic
Thomas T. Kim, Chungwoo Lee, Dongwook Kim, Hee-Seung Lee, Sunkyu Han
Summary: In this paper, we present the synthesis and reactivity of 1-hydroxyherquline A, and discuss the challenges encountered during its conversion to herquline A. These findings provide valuable insights for future research and synthesis of herquline A.
Review
Biochemistry & Molecular Biology
Seoneun Jeong, Kwonjung Lee, Sung Hyun Yoo, Hee-Seung Lee, Sunbum Kwon
Summary: Metal-peptide networks are structures assembled from short peptides and metal ions, known for their unique and complicated features. However, limitations such as designability, stability, and modifiability have hindered their practical applications. This review summarizes important milestones in the development of crystalline metal-peptide networks and analyzes their structural features and potential applications, providing insights for the development of new metal-peptide networks with more sophisticated structures and novel functions.
Article
Biochemistry & Molecular Biology
Taewoo Kim, Hyun Su Kim, Jaebong Jang, Dong-Jun Kim, Jongkook Lee, Dongjoo Lee, Seok-Ho Kim
Summary: This paper presents a concise and scalable method for synthesizing the phytoestrogen 7,2'-dihydroxy-4',5'-dimethoxyisoflavanone. The key steps of the synthesis include the construction of the deoxybenzoin unit and the efficient synthesis of the isoflavanone architecture.
Article
Chemistry, Multidisciplinary
Sung Hyun Yoo, Jintaek Gong, Lianjin Zhang, Seoneun Jeong, Jin Kim, Hee-Seung Lee
Summary: This study reported transition metal complexes from an unnatural beta-amino acid, showing different coordination modes and structural features.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Dohyun Yoo, Chang-Hee Whang, Jungwoo Hong, Dohyeon Kim, Monica Celine Prayogo, Youngju Son, Wonsik Jung, Seojung Lee, Hee-Seung Lee, Sangyong Jon
Summary: Current medications for inflammatory bowel disease (IBD) have limited effectiveness and severe side effects. Therefore, there is an urgent need for novel therapeutic approaches that can specifically target inflamed areas in the gastrointestinal tract with minimal systemic effects. In this study, researchers constructed a library of anti-inflammatory nanoparticles called GlyNPs and evaluated their therapeutic potential in a mouse model of IBD. By attaching bilirubin (BR) to a library of glycopolymers, the researchers identified a candidate GlyNP capable of targeting macrophages in the inflamed colon and effectively alleviating colitis symptoms. These findings suggest that the BR-attached GlyNP library can serve as a platform for identifying anti-inflammatory nanomedicines for various inflammatory diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Danim Lim, Wonchul Lee, Jungwoo Hong, Jintaek Gong, Jonghoon Choi, Jaewook Kim, Seolhee Lim, Sung Hyun Yoo, Yunho Lee, Hee-Seung Lee
Summary: We introduce a novel cyclic β-amino acid, trans-(3S,4R)-4-aminotetrahydrothiophene-3-carboxylic acid (ATTC), as a versatile building block for designing peptide foldamers with controlled secondary structures. Our findings reveal that ATTC-containing foldamers can adopt 12-helical conformations similar to their isosteres and offer the possibility of fine-tuning their properties via post-synthetic modifications. In particular, chemoselective conjugation strategies demonstrate that ATTC provides unique post-synthetic modification opportunities, which expand their potential applications across diverse research areas.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jaewook Kim, Jungwoo Hong, Mi Jeong Park, Hee-Seung Lee
Summary: This groundbreaking research uncovers an approach for crafting chiral channels in metal-peptide networks (MPNs). The strategic integration of foldamer ligands and CuI clusters allows precise, atomic-level modifications. The technique expedites enantiomer discrimination in mixtures and prompts adaptable molecules to adopt specific chiral forms. It promises the potential for multifunctional materials useful in catalysis, drug delivery, and sensing technologies.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jungwoo Hong, Wonchul Lee, Hee-Seung Lee
Summary: This article presents an optimized method for the stereoselective synthesis of five-membered alicyclic and heterocyclic trans-beta-amino acid derivatives, which allows for high yields and scalable production of the desired building blocks.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Jihye Park, Hee-Seung Lee, Hyungjun Kim, Jeong-Mo Choi
Summary: In this study, we assessed the performance of three popular force fields in predicting the conformational propensities of a beta-peptide foldamer. Our results showed the unanimous role of hydrogen bonds in shaping energy landscapes. These findings contribute to the improvement of force fields and understanding the role of solvents in peptide folding, crystallization, and engineering.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
