Journal
CANCER LETTERS
Volume 334, Issue 2, Pages 196-201Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.09.013
Keywords
Quantum dots; Gold nanoparticles; Cell surface differentiation; Sensor array
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Funding
- NSF Center for Hierarchical Manufacturing at the University of Massachusetts [CMMI-1025020]
- NIH [GM077173]
- China scholarship council for the state scholarship fund
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We demonstrate rapid and efficient sensing of mammalian cell types and states using nanoparticle-based sensor arrays. These arrays are comprised of cationic quantum dots (QDs) and gold nanoparticles (AuNPs) that interact with cell surfaces to generate distinguishable fluorescence responses based on cell surface signatures. The use of QDs as the recognition elements as well as the signal transducers presents the potential for direct visualization of selective cell surface interactions. Notably, this sensor is unbiased, precluding the requirement of pre-knowledge of cell state biomarkers and thus providing a general approach for phenotypic profiling of cell states, with additional potential for imaging applications. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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