Journal
CANCER LETTERS
Volume 329, Issue 2, Pages 137-145Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.10.036
Keywords
Cidofovir; Cervical cancer; Human papillomavirus; Xenografts; IL-6
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Cidofovir has shown antiproliferative effects against human papillomavirus (HPV)-positive cells and successfully suppressed the growth of HPV-positive xenografts in athymic nude mice. The present study evaluated the effect of cidofovir on several disease parameters in this animal model. Intratumoral administration of cidofovir resulted in a beneficial effect on body weight gain, a reduction in splenomegaly, a partial restoration of tryptophan catabolism, and diminished the inflammatory state induced by the xenografts. Administration of cidofovir to tumor-free animals did not have a direct effect on these parameters. Beyond suppressing tumor growth, intratumoral treatment with cidofovir ameliorated the pathology associated with HPV-tumor growth. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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