Journal
CANCER LETTERS
Volume 330, Issue 1, Pages 57-66Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.11.020
Keywords
Breast cancer; High throughput proteomics; Circulating markers
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This study evaluated the plasmatic proteomic profile of breast cancer patients in the early (ED) and advanced (AD) stages, employing high-throughput proteomics. We identified 92 differentially expressed proteins in ED and 73 proteins in AD patients. Gelsolin, lumican, clusterin, SALL4 and PMS2, as well hTERT, TNF-alpha, and GRHL3 were chosen for further investigation. ED presented augmented expression of GRHL3 and reduced circulating TNF-alpha with high expression of GRHL3 in tumors. AD displayed high TNF-alpha, and a significant expression of PMS2 in tumors. These findings suggest processes enrolling stem cell division in ED, with TNF-alpha signaling and DNA mismatch repair in the advanced stage. (C) 2012 Published by Elsevier Ireland Ltd.
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