Article
Biotechnology & Applied Microbiology
Jiancheng Wang, Ye Wang, Junfu Wang, Siwen Zhang, Zhu Yu, Kaitian Zheng, Zhao Fu, Congjun Wang, Weijia Huang, Junqiang Chen
Summary: The DEAD-box helicase (DDX) family plays a critical role in cancer initiation and progression through alternative splicing, transcription, and ribosome biogenesis. DDX56, a member of this family, is overexpressed in several cancers and exhibits an oncogenic role. This study demonstrated the aberrant expression of DDX56 in gastric cancer through high-throughput sequencing and functional studies, shedding light on its biological role and potential therapeutic target in gastric cancer.
Article
Biochemistry & Molecular Biology
Xiukun Cui, Chunxiao Du, Simin Wan, Dandan Wu, Longjun Yan, Jing Zhang, Jing Li, Hui Li, Zhengyan Yang, Hailong Zhang, Jun Zhang, Hongmei Mu, Fengyan Zhang, Xuyan Peng, Mugen Liu, Yanzhong Hu
Summary: Genetic mutations in heat shock factor 4 (Hsf4) are linked to congenital and age-related cataracts. Hsf4 acts as a suppressor of p21(cip1) expression and plays an anti-senescence role in lens epithelial cells. Hsf4 protects against cellular senescence during lens development and aging by fine-tuning p21(cip1) expression.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Isabel de Pedro, Jesus Galan-Vidal, Ana Freije, Ernesto de Diego, Alberto Gandarillas
Summary: p21 plays a crucial role in driving keratinocytes towards differentiation in response to genomic stress by intervening in the mitosis block. Loss of p21 allows cells to escape differentiation and continue proliferation, while also driving keratinocytes from differentiation to apoptosis.
Article
Multidisciplinary Sciences
Amr. R. Ghanam, Shengwei Ke, Shujuan Wang, Ramy Elgendy, Chenyao Xie, Siqi Wang, Ran Zhang, Min Wei, Weiguang Liu, Jun Cao, Yan Zhang, Zhi Zhang, Tian Xue, Yong Zheng, Xiaoyuan Song
Summary: This study reveals the uncharacterized function of lncRNA Malat1 in cancer-associated aging. It shows that Malat1 interacts with different proteins in the brain of young mice and aged mice. The study also identifies the differential expression of two Malat1 isoforms in retina and brain, indicating their roles in gene regulation. Moreover, the study demonstrates the impact of these isoforms on retinal oxidative stress and corneal opacity with age.
Article
Oncology
Meixia Ke, Ning Sun, Zhenni Lin, Peipei Zhang, Yan Hu, Shuilian Wu, Zhijian Zheng, Yongyong Lu, Honglei Jin
Summary: SNHG18 is significantly downregulated in bladder cancer tissues and cell lines. It inhibits c-Myc expression by modulating the ubiquitination-proteasome pathway, leading to the transcription and expression of p21. This finding reveals a novel regulatory mechanism involving the SNHG18/c-Myc/p21 pathway in bladder cancer pathogenesis and provides potential lncRNA-based diagnostics and therapeutics for bladder cancer.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Rui Chen, Thomas Skutella
Summary: This review proposes a novel strategy of establishing a rejuvenating microenvironment through senescent cells specific reprogramming. It discusses the potential benefits of partial reprogramming in facilitating cellular rejuvenation and improving the senescence-associated secretory phenotype. It also explores the potential of intervening in cellular senescence to improve aging and promote damage repair, while emphasizing the importance of feasible and safe clinical translational protocols.
Article
Cell Biology
Mayank Maheshwari, Nisha Yadav, Mohammad Hasanain, Praveen Pandey, Rohit Sahai, Kuldeep Choyal, Akhilesh Singh, Mushtaq A. Nengroo, Krishan K. Saini, Deepak Kumar, Kalyan Mitra, Dipak Datta, Jayanta Sarkar
Summary: The article discusses the dual function of p21 in cancer, with both inhibitory and oncogenic effects. Specifically, p21 negatively regulates basal autophagy and has oncogenic activity during early tumor development, while its inhibition promotes survival and growth of established tumors.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Yapei Huang, Juliana E. Shin, Alexander M. Xu, Changfu Yao, Sandy Joung, Min Wu, Ruan Zhang, Bongha Shin, Joslyn Foley, Simeon B. Mahov, Matthew E. Modes, Joseph E. Ebinger, Matthew Driver, Jonathan G. Braun, Caroline A. Jefferies, Tanyalak Parimon, Chelsea Hayes, Kimia Sobhani, Akil Merchant, Sina A. Gharib, Stanley C. Jordan, Susan Cheng, Helen S. Goodridge, Peter Chen
Summary: Host factors such as age, sex, obesity, and other comorbidities can impact the effectiveness of COVID-19 vaccines. A study identified healthcare workers with unexpectedly low antibody levels after receiving the BNT162b2 vaccine. These individuals had fewer antibody-producing cells and weaker T cell responses, potentially due to premature lymphocyte aging.
Article
Cell Biology
Yaxuan Wang, Haixia Zhu, Haifei Xu, Yifan Qiu, Yonghong Zhu, Xiaolin Wang
Summary: Patients with advanced bladder cancer often develop chemoresistance, leading to tumor recurrence. In this study, the senescence program in solid tumors was shown to improve short-term drug sensitivity. The important role of c-Myc in bladder cancer cell senescence was determined using bioinformatics analysis. The study also revealed that reducing the expression levels of c-Myc and HSP90B1 could inhibit bladder cancer cell proliferation, promote cellular senescence, and enhance cisplatin chemosensitivity. The HSP90B1/c-Myc interaction was found to regulate the p21 signaling pathway, which affects cisplatin sensitivity by modulating bladder cancer cell senescence.
Article
Oncology
Ying Chen, Jin Wen, Qian Li, Danyue Peng, Chenxi Liao, Xiao Ma, Mengyuan Wang, Jialan Niu, Di Wang, Yingnan Li, Xiaolan Zhang, Hao Zhou, Jing Zou, Lei Li, Lingbo Liu
Summary: This study reveals that increased RAB27B in leukaemia stem cells (LSCs) inhibits senescence and maintains stemness through the regulation of exosome secretion. The increased RAB27B promotes the loading and release of senescence-inducing proteins in exosomes, and the exosomes derived from RAB27B-regulated LSCs induce senescence of mesenchymal stem cells (MSCs). In turn, the senescent MSCs facilitate LSC maintenance through the selective excretion of exosomes enriched with stemness-promoting proteins.
Article
Multidisciplinary Sciences
Moh'd Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann
Summary: One major obstacle in diabetes is the hyperglycemic memory, which lacks specific therapies. In diabetic kidney disease (DKD), glucose-mediated changes in gene expression persist even after reversing hyperglycemia. The gene p21, associated with the p53-p21 pathway, is found to be consistently induced by hyperglycemia and linked to DKD severity. The sustained expression of p21 in DKD is associated with demethylation of its promoter and reduced DNMT1 expression. Two disease resolving agents, 3K3A-aPC and parmodulin-2, can reverse the sustained p21 expression, tubular senescence, and DKD, highlighting p21 as a potential therapeutic target for hyperglycemic memory in DKD.
NATURE COMMUNICATIONS
(2022)
Article
Toxicology
Yan Cheng, Lina Zheng, Chenyi Yang, Weiwei Zhang, Haiyun Wang
Summary: The study showed that propofol has anti-tumor effects on glioma cells by upregulating the expression of GAS5 and affecting related signaling pathways.
TOXICOLOGY IN VITRO
(2022)
Article
Medicine, Research & Experimental
Enyi Gao, Xiaoya Sun, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Fengmin Shao, Jianli Ma, Mian Wu
Summary: NIPSNAP1 is identified as a mediator of c-Myc function and a negative regulator of cellular senescence in cancer cells. It promotes cancer cell proliferation by maintaining c-Myc levels and prevents senescence by modulating ROS levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Markus Kaller, Wenjing Shi, Heiko Hermeking
Summary: Loss of AP4 in breast cancer cells leads to DNA damage, senescence, and reduced proliferation. Deletion of p53 can reverse the senescence and proliferation defects in AP4-deficient cells. Loss of AP4 enhances the repression of DREAM and E2F target genes induced by c-MYC through p53.
Article
Oncology
Ahmed M. Elshazly, Melanie M. Sinanian, Victoria Neely, Eesha Chakraborty, Muruj A. Alshehri, Michael K. McGrath, Hisashi Harada, Patricia V. Schoenlein, David A. Gewirtz
Summary: Breast cancer is a common malignancy in women, with ER+ breast cancer accounting for 70% of cases. Current standard treatment includes the use of estrogen antagonists and CDK4/6 inhibitors, but disease recurrence and metastasis remain a challenge. This study explores the potential of BET family inhibitors to improve the response to current therapies.
Article
Immunology
Qiang Shan, Sheng'en Hu, Xia Chen, Derek B. Danahy, Vladimir P. Badovinac, Chongzhi Zang, Hai-Hui Xue
Summary: The study demonstrates that ectopic Tcf1 expression promotes the generation of stem cell-like Tex cells in chronic viral infection and tumor models, enhancing their functionality and response to checkpoint blockade. This highlights the therapeutic potential of harnessing Tcf1-enforced transcriptional programs for viral and tumor control.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Stina L. Urban, Isaac J. Jensen, Qiang Shan, Lecia L. Pewe, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Article
Immunology
Pengcheng Du, Chuan Song, Rui Li, Yangzi Song, Jiarui Li, Nan Ding, Ju Zhang, Rui Song, Junyan Han, Guiju Gao, Jinglin Yue, Ang Duan, Yanyi Huang, Jing An, Jianbin Wang, Fujie Zhang, Chen Chen, Hui Zeng
Summary: Intrahost analysis of SARS-CoV-2 genomic sequences identified 2 viral haplotypes with 3 genetically linked mutations from a patient's respiratory and intestinal tracts. The spatiotemporal data suggest that the patient initially had dual infection of 2 SARS-CoV-2 variants, which then redistributed into the two systems.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biology
Xin Zhao, Peng Shao, Kexin Gai, Fengyin Li, Qiang Shan, Hai-Hui Xue
Article
Infectious Diseases
Yangzi Song, Chen Chen, Yu Wang, Ju Zhang, Meiling Chen, Guiju Gao, Sa Wang, Di Yang, Rui Song, Linghang Wang, Wen Xie, Fengting Yu, Liting Yan, Yajie Wang, Hui Zeng, Fujie Zhang
Summary: The study highlights the importance of early, consecutive, and combined double testing in identifying infected patients, especially for asymptomatic and mild symptomatic cases, to minimize misdiagnosis and ineffective isolation of infected patients in the absence of effective treatments or vaccines.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Letter
Biology
Junyan Han, Ning Zhang, Danying Chen, Yuhuan Gong, Guoli Li, Yaxian Kong, Lin Pu, Chen Chen, Jingyuan Liu, Qi Wang, Ju Zhang, Xuesen Zhao, Juan Du, Kai Han, Chuan Song, Linghang Wang, Mingxi Hua, Yu Hao, Rui Song, Yangzi Song, Fengting Yu, Siyuan Yang, Haofeng Xiong, Wei Zhang, George F. Gao, Fujie Zhang, Ang Li, Hui Zeng, Yuhai Bi
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, Jiaming Zhang, Christian Laggner, Kong T. Nguyen, Zhichuan Zhu, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu
Summary: Chromosomal translocation leads to the formation of the EWS-FLI1 fusion oncogene in Ewing sarcoma, with SPOP identified as the E3 ligase and OTUD7A as the deubiquitinase regulating EWS-FLI1 protein stability. Targeting OTUD7A with the inhibitor 7Ai shows potential as a therapeutic strategy for Ewing sarcoma dependent on EWS-FLI1 and related fusions.
Article
Genetics & Heredity
Jing Fu, Ju Zhang, Li Yang, Nan Ding, Liya Yue, Xiangli Zhang, Dandan Lu, Xinmiao Jia, Cuidan Li, Chongye Guo, Zhe Yin, Xiaoyuan Jiang, Yongliang Zhao, Fei Chen, Dongsheng Zhou
Summary: The study systematically investigated the methylation features of Klebsiella pneumoniae and identified 15 methylation motifs. The distribution patterns of these motifs in the genome were analyzed and the methylation dynamics were characterized at single-base resolution. The findings provide useful insights into the epigenetic regulation of K. pneumoniae and other bacterial species.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Cell Biology
Jiarui Li, Pengcheng Du, Lijiang Yang, Ju Zhang, Chuan Song, Danying Chen, Yangzi Song, Nan Ding, Mingxi Hua, Kai Han, Rui Song, Wen Xie, Zhihai Chen, Xianbo Wang, Jingyuan Liu, Yanli Xu, Guiju Gao, Qi Wang, Lin Pu, Lin Di, Jie Li, Jinglin Yue, Junyan Han, Xuesen Zhao, Yonghong Yan, Fengting Yu, Angela R. Wu, Fujie Zhang, Yi Qin Gao, Yanyi Huang, Jianbin Wang, Hui Zeng, Chen Chen
Summary: This study analyzes clinical samples from patients with COVID-19 and finds that genetic diversity increases in individuals after symptom onset. Nonsynonymous mutations are more common within individuals but less prevalent at the population level, suggesting a two-step fitness selection process. Dynamic changes in iSNVs among different populations indicate differences in the fitness selection process.
Article
Immunology
Jia Liu, Shaoqi Zhu, Wei Hu, Xin Zhao, Qiang Shan, Weiqun Peng, Hai-Hui Xue
Summary: Xue, Peng, and colleagues used multiomics approaches including Hi-C to demonstrate that CTCF promotes cytotoxic effector differentiation through dynamic redistribution, local chromatin accessibility control, and higher-order genomic reorganization, while enclosing memory precursor-associated genes within insulated neighborhoods to restrain their activation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Beibei Wang, Liuluan Zhu, Bei Jia, Chenchen Zhao, Ju Zhang, Fangyuan Li, Jiarui Li, Nan Ding, Can Zhang, Yu Hao, Shuai Tong, Jiajia Wang, Guoli Li, Yang Fan, Henghui Zhang, Rui Li, Juan Du, Yaxian Kong, Yue Zhang, Xiaoyu Yang, Junyan Han, Zhengya Yu, Zhongtao Du, Hong Zheng, Christian Kosan, Ang Li, Chen Chen, Yaluan Ma, Hui Zeng
Summary: In patients with sepsis, secondary infection triggers a new wave of inflammatory response, worsening organ damage and increasing mortality. Primary infection reprograms granulocytes to enhance their inflammatory response to secondary infection, but these reprogrammed granulocytes exhibit non-classic characteristics of innate immune memory.
Review
Immunology
Xudong Zhao, Qiang Shan, Hai-Hui Xue
Summary: TCF1 plays essential roles in early T cell development and exhibits versatile, context-dependent functions in mature T cells. It is required for the self-renewal of stem-like CD8(+) T cells and regulates T cell responses effectively.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ju Zhang, Nan Ding, Yangzi Song, Rui Song, Yang Pan, Linghang Wang, Shuo Yan, Qi Wang, Shanfang Ma, Lirong Wei, Fengting Yu, Lianhe Lu, Fujie Zhang, Chen Chen, Hui Zeng
Summary: The study traced asymptomatic transmission of COVID-19 patients using a novel sequencing technology and provided phylogenomic evidence. The findings suggest that current screening measures may need to consider covering asymptomatic individuals.
Article
Biology
Keyin Zhang, Ju Zhang, Nan Ding, Lucas Zellmer, Yan Zhao, Siqi Liu, Dezhong Joshua Liao
Summary: Through polyacrylamide gel electrophoresis and LC-MS/MS, the identities of ACTB and GAPDH proteins were determined, indicating they are not suitable as reference genes for determining protein loading in techniques like Western blotting.
OPEN LIFE SCIENCES
(2021)
Letter
Biochemistry & Molecular Biology
Siyuan Su, Jianfeng Chen, Ying Wang, Lilly M. Wong, Zhichuan Zhu, Guochun Jiang, Pengda Liu
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
