Article
Biochemistry & Molecular Biology
Jingjing Liu, Qi Zhang, Changli Wang, Jiaying Yang, Sheng Yang, Tianyi Wang, Bing Wang
Summary: The expression of BAP31 is increased in hepatocellular carcinoma (HCC) and its knockdown enhances the sensitivity of cancer cells to Doxorubicin. This is achieved by downregulating survivin expression and promoting cell apoptosis. BAP31 may serve as a potential therapeutic target for improving the treatment response of Doxorubicin-resistant HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hui Shao, Jingyan Chen, Ali Li, Lili Ma, Yongzhi Tang, Huazhong Chen, Yongping Chen, Junyan Liu
Summary: Salvigenin inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells by reducing glucose uptake and lactate production, suppressing glycolysis, and enhancing sensitivity to 5-fluorouracil.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Jinda Bian, Dan Zhang, Yicun Wang, Hanjiao Qin, Wei Yang, Ranji Cui, Jiyao Sheng
Summary: Mitochondria play a crucial role in the progression of hepatocellular carcinoma by regulating processes such as redox homeostasis, metabolism, and cell death pathways. Quality control mechanisms in mitochondria can repair or eliminate unhealthy mitochondria, forming an efficient integrated network. Understanding the impact of mitochondria on the biological behavior of HCC is important for developing precision medicine approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manal Alfwuaires, Hany Elsawy, Azza Sedky
Summary: This study suggests that ACN can inhibit the activation of STAT3 and suppress the expression of genes associated with HCC, making it a promising therapeutic compound for the treatment of HCC and other cancers.
Article
Oncology
Shi-Zhe Zhang, Xiao-Dong Zhu, Long-Hai Feng, Xiao-Long Li, Xue-Feng Liu, Hui-Chuan Sun, Zhao-You Tang
Summary: The study revealed that high expression of PCSK9 in hepatocellular carcinoma (HCC) is associated with microvascular invasion and large tumor size, leading to poor overall survival and disease-free survival in patients. Experimental findings demonstrated that PCSK9 promotes HCC growth by inhibiting cell apoptosis, with FASN-mediated anti-apoptosis playing a significant role in this process.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Chao-Jen Li, Hung-Wen Tsai, Yi-Li Chen, Chun- Wang, Yang-Hsiang Lin, Pei-Ming Chu, Hsiang-Cheng Chi, Yi-Ching Huang, Cheng-Yi Chen
Summary: Hepatocellular carcinoma (HCC) is difficult to cure due to rapid cell growth, high recurrence rate, and drug resistance. This study found that PTP4A3 is closely associated with the survival rates of HCC patients and its downregulation decreases HCC cell viability. The IL-6R-JAK2-STAT3 cascade is involved in the modulation of HCC cell survival and drug resistance by PTP4A3.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Gastroenterology & Hepatology
Xiao-Cui Wei, Ya-Ru Xia, Ping Zhou, Xing Xue, Shuang Ding, Li-Juan Liu, Fan Zhu
Summary: The study focused on how HBc promotes Doxorubicin resistance in HCC. Results showed that HBc increased the expression of exosomal miR-135a-5p, leading to anti-apoptosis, cell proliferation, and chemotherapy resistance in HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Wenliang Tan, Kelin Zhang, Xinming Chen, Lei Yang, Sicong Zhu, Yingcheng Wei, Zhiqin Xie, Yajin Chen, Changzhen Shang
Summary: This study revealed that Lenvatinib can induce apoptosis in HCC cells by increasing reactive oxygen species levels, with GPX2 identified as a crucial target for Lenvatinib against HCC. It was found that GPX2 was highly expressed in tumor tissues and correlated with poor overall survival in HCC patients. Furthermore, Lenvatinib was shown to inhibit GPX2 expression in HCC cells by preventing the nuclear translocation of β-catenin. These findings suggest that GPX2 may play an important role in Lenvatinib-induced HCC cell apoptosis and can serve as a biomarker for guiding Lenvatinib therapy in HCC patients.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Oncology
Adriana G. Quiroz Reyes, Sonia A. Lozano Sepulveda, Natalia Martinez-Acuna, Jose F. Islas, Paulina Delgado Gonzalez, Tania Guadalupe Heredia Torres, Jorge Roacho Perez, Elsa N. Garza Trevino
Summary: Hepatocellular carcinoma (HCC) is a highly lethal and recurrent liver cancer, with death mainly caused by tumor progression, recurrence, metastasis, and chemoresistance. Cancer stem cells (CSCs) within the tumor promote invasion, recurrence, metastasis, and drug resistance. Hepatic stellate cells (HSCs) in the tumor microenvironment (TME) play important roles in fibrogenesis, tumor infiltration, and HCC development. Interactions between HSC and CSC, as well as their microenvironment, contribute to carcinogenesis through various mechanisms. This review summarizes the roles of CSCs and HSCs in establishing the TME in primary liver tumors and their involvement in HCC chemoresistance.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Review
Cell Biology
Mehrdad Hashemi, Niloufar Nadafzadeh, Mohammad Hassan Imani, Romina Rajabi, Setayesh Ziaolhagh, Seyedeh Delaram Bayanzadeh, Raheleh Norouzi, Reihaneh Rafiei, Zeinab Khazaei Koohpar, Behnaz Raei, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Maliheh Entezari, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis, Shing Cheng Tan
Summary: Autophagy is a conserved process that regulates homeostasis, but dysregulation is observed in human diseases, especially cancer. Autophagy has dual roles in hepatocellular carcinoma (HCC), potentially promoting tumor survival or death. Activation of autophagy may induce epithelial-mesenchymal transition and regulate proliferation and glucose metabolism in HCC. Targeting autophagy impairs tumor growth and metastasis in HCC and improves response to therapy.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Fan Feng, Lianhong Pan, Jiaqin Wu, Lanqing Li, Haiying Xu, Li Yang, Kang Xu, Chunli Wang
Summary: Cepharanthine (CEP), extracted from Stephania cepharantha Hayata, has shown potential in treating hepatocellular carcinoma (HCC) by inhibiting cell migration, proliferation, and inducing apoptosis. Through RNA-seq and GC-MS, CEP was found to affect metabolism-associated pathways and down-regulate metabolites, leading to significant antitumor effects in both in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Luhao Li, Suxin Li, Haohao Wang, Lin Li, Peiju Wang, Dongqi Shen, Xiaowei Dang
Summary: The study revealed that GSG2 is overexpressed in HCC tissues, and knockdown of GSG2 can inhibit the progression of HCC, promote cell apoptosis, and potentially participate in the oncogenesis of HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Cell Biology
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang
Summary: The study demonstrated that ginkgetin has an anti-tumor effect on human hepatocellular carcinoma cell lines by inducing apoptosis through affecting the balance between cell proliferation and apoptosis.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
