Article
Neurosciences
Jovana Drljaca, Aleksandra Popovic, Dragica Bulajic, Nebojsa Stilinovic, Sasenka Vidicevic Novakovic, Slobodan Sekulic, Ivan Milenkovic, Srdan Ninkovic, Marko Ljubkovic, Ivan Capo
Summary: This study investigates the combined effects of TMZ and DIA on GBM cells. The results show that there is antagonism between TMZ and DIA, and DIA decreases the apoptosis level caused by TMZ. Additionally, the concomitant use of TMZ and DIA increases the mitochondrial bioenergetic response and the activities of key complexes in the electron transport chain.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Yan Zou, Yajing Sun, Yibin Wang, Dongya Zhang, Huiqing Yang, Xin Wang, Meng Zheng, Bingyang Shi
Summary: Researchers have developed a novel nanomedicine that combines cancer cell-mitochondria hybrid membrane with Gboxin-loaded nanoparticles. This nanomedicine shows promising anti-tumor responses in glioblastoma models, with improved blood circulation, tumor accumulation, and targeting capabilities.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Matsuda, Fumihiko Nishimura, Mitsutoshi Nakamura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Takahiro Tsujimura, Hiroyuki Nakase
Summary: Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults with poor survival rates. Immunotherapy utilizing Natural killer (NK) cells shows promise in treating GBM by exerting a cytotoxic effect on tumor cells. Preclinical evaluation using an ex vivo 3D spheroid model derived from GBM cell lines showed that NK cells had an anti-tumor effect by inducing tumor cell death through apoptosis, providing valuable information for future NK cell-based immunotherapy for GBM patients.
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Peripheral Vascular Disease
Khushbu Rauniyar, Honey Bokharaie, Michael Jeltsch
Summary: This study comprehensively analyzed the evolutionary relationships of PDGF/VEGF growth factors and proposed a phylogenetic tree. Whole-genome duplications in vertebrates contribute to the diversity of PDGF/VEGF, but limited duplications are necessary to explain the emergence pattern. The oldest phylogenetically PDGF/VEGF-like growth factor likely had a BR3P signature in the C-terminus, similar to modern lymphangiogenic growth factors. Some younger VEGF genes are absent in specific vertebrate clades, while PDGF/VEGF gene duplications frequently occur in fish on top of fish-specific whole-genome duplications.
Review
Chemistry, Medicinal
Tayfun Tanir, Marvin Orellana, Aster Escalante, Carolina Moraes de Souza, Michael S. Koeris
Summary: This article provides an overview of the process and challenges of phage manufacturing, including cell line development, upstream and downstream processing, as well as the additional opportunities presented by engineered bacteriophages.
Review
Cell Biology
Xiaonan Liu, Peilin Zhang, Yuan Gu, Qiaoyue Guo, Yonggan Liu
Summary: Type H vessels are specialized blood vessels in the bone marrow that play a crucial role in osteogenic activity and bone diseases. They provide nutritional support and regulate the proliferation and differentiation of bone cells, facilitating new bone formation. Understanding the molecular mechanisms of type H vessels can provide insights into bone metabolism and therapeutic strategies for bone diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Alessandro Certelli, Paolo Valente, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Rosalinda D'Amico, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: In diabetic mouse skin, controlled co-delivery of TG-VEGF and TG-PDGF-BB recombinant proteins effectively induces angiogenesis and arteriogenesis, with similar efficacy to normal littermate control mice at therapeutically relevant doses. This approach also prevents abnormal vascular enlargement caused by high TG-VEGF levels and promotes effective arteriogenesis in the dermal layer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Hiroyuki Ogawa, Kosuke Kaji, Norihisa Nishimura, Hirotetsu Takagi, Koji Ishida, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Summary: Lenvatinib shows potential as a novel therapeutic strategy for liver fibrosis by inhibiting hepatic stellate cell proliferation and promoting apoptosis, as well as reducing protein expression levels and intrahepatic neovascularization.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Monika Szeliga, Radoslaw Rola
Summary: This study identified a considerable amount of TrxR1 protein in GBM tissues, suggested TrxR1 as an attractive drug target, and highlighted AF as a potential off-patent drug candidate in GBM therapy. Treatment with AF decreased viability of GBM cells, increased ROS levels, and its cytotoxic effect was potentiated by treatment with MEN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giusi Alberti, Claudia Campanella, Letizia Paladino, Rossana Porcasi, Celeste Caruso Bavisotto, Alessandro Pitruzzella, Francesca Graziano, Ada Maria Florena, Antonina Argo, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello, Fabio Bucchieri, Rosario Barone, Francesca Rappa
Summary: In this study, four cell lines associated with glioblastoma were established, and high levels of chaperones and factors connected to malignancy were observed in these cell lines. The tumors also showed increased levels of chaperones, indicating their potential as diagnostic-prognostic biomarkers and targets for anti-cancer compounds.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Infectious Diseases
Shinichiro Morichi, Gaku Yamanaka, Yusuke Watanabe, Tomoko Takamatsu, Akiko Kasuga, Mika Takeshita, Soken Go, Yu Ishida, Shingo Oana, Yasuyo Kashiwagi, Hisashi Kawashima
Summary: The study found significantly elevated levels of HMGB1 and angiogenesis-related growth factors in children with acute encephalopathy and meningitis, which correlated with levels of interleukins in cerebrospinal fluid. These factors may play pivotal roles in the pathophysiology of central nervous system infections.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Ana Salome Correia, Rita Matos, Fatima Gartner, Irina Amorim, Nuno Vale
Summary: Drug repurposing and drug combination are crucial strategies in cancer therapy to combat drug resistance and enhance treatment outcomes. However, feline mammary carcinoma cells showed high resistance to tested drugs compared to human breast cancer cells, indicating potential differences in drug response across different types of cancer cells.
Article
Oncology
Jamilet Miranda, Dania Vazquez-Blomquist, Ricardo Bringas, Jorge Fernandez-de-Cossio, Daniel Palenzuela, Lidia I. Novoa, Iraldo Bello-Rivero
Summary: HeberFERON displays a distinctive effect compared to individual interferons in the U-87MG model, particularly in cell cycle related events. Through transcriptional expression profiling, it was found that HeberFERON targets a series of genes related to the cell cycle, such as the transition from prometaphase to anaphase. Additionally, HeberFERON affects the cell cycle by regulating the FOXM1 transcription factor, p53 phosphorylation, and MDM2-mediated ubiquitination, and it plays a role in cell proliferation.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
