Journal
CANCER LETTERS
Volume 309, Issue 2, Pages 199-208Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.06.002
Keywords
Akt; Cyclin; GAIP; PI3K; RGS19
Categories
Funding
- Hong Kong RGC [HKUST1/06C, 644306, 663110]
- UGC [AoE/B-15/01]
- Hong Kong Jockey Club
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RGS19 is a regulator of G protein signaling which is upregulated in ovarian cancers and its overexpression promotes cell proliferation in several mammalian cell types. Here we showed that cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced. Moreover, RGS19 augmented serum-stimulated PTEN/PDK/Akt and Rb phosphorylations in 293/RGS19 and Caco2/RGS19 cells. These changes were reversed upon the knockdown of RGS19. Consistent with an elevated Akt activity, increased levels of phosphorylated Bad and c-Raf and a diminished expression of TSC2 were detected, thus demonstrating that RGS19 can deregulate cell proliferation via multiple pathways. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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