Article
Oncology
Chul Min Yang, Moo-Koo Kang, Woong-Jae Jung, Jung-Sik Joo, Yong-Jin Kim, Yeeun Choi, Hyoung-Pyo Kim
Summary: p53, a critical tumor suppressor protein, influences drug sensitivity in a transcription-independent manner by regulating chromatin accessibility of genes associated with cell apoptosis. Treatment with 5-FU leads to global increases in chromatin accessibility, with chromatin organization in specific genomic regions being influenced by p53 expression status.
Article
Immunology
Aranka Brockmueller, Constanze Buhrmann, Parviz Shayan, Mehdi Shakibaei
Summary: This study demonstrates a negative reciprocal crosstalk between p53 and Sirt-1, and high concentrations of resveratrol can induce apoptosis in colorectal cancer cells by modulating the expression of these two proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chao Song, Dongmei Shi, Kaiwen Chang, Xianghui Li, Qing Dong, Xia Ma, Xuefei Wang, Zhenhuan Guo, Yonglu Liu, Jundong Wang
Summary: Fluoride-induced pulmonary toxicity is related to cell apoptosis, with activation of caspase-8 and induction of DR5 playing critical roles. NOX4 and p53 mediate the expression of DR5 induced by NaF, influencing pulmonary apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xue Wang, Yi Liu, Kaiyuan Li, Ming Yang, Qingtao Wang, Zhihui Hao
Summary: This study explored the effects of triacetyl resveratrol (TCRV) on porcine epidemic diarrhea virus (PEDV) and found that TCRV could inhibit PEDV infection by inducing early apoptosis of PEDV-infected cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sayanta Dutta, Sushweta Mahalanobish, Sukanya Saha, Mullicka Mandal, Sanchari Begam, Pritam Sadhukhan, Sumit Ghosh, Goutam Brahmachari, Parames C. Sil
Summary: Selective initiation of programmed cell death in cancer cells was achieved by a synthetic bis-coumarin derivative 3 l, which demonstrated promising cytotoxic ability and apoptosis induction specifically in human renal carcinoma cells (SKRC-45). This compound modulated apoptotic pathways and inhibited NF-kappa B nuclear localization, resulting in reduced proliferation, survival, and migration ability of SKRC-45 cells. In an in vivo tumor model, 3 l exhibited an anticancer effect without affecting kidney function.
CELLULAR SIGNALLING
(2023)
Article
Chemistry, Medicinal
Zhitao Ren, Nishikant A. Raut, Temitope O. Lawal, Shital R. Patel, Simon M. Lee, Gail B. Mahady
Summary: Anthocyanins and resveratrol have been shown to promote proliferation and differentiation of human osteoblasts, reduce apoptosis, and regulate mitochondrial and epigenetic pathways, suggesting potential benefits for bone health.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Physical
Jennifer Ortiz Letechipia, Consuelo Letechipia de Leon, Hector Rene Vega-Carrillo, David Alejandro Garcia Lopez, Sergio Hugo Sanchez Rodriguez
Summary: This study evaluated the cell viability and protein expression in human leukocytes exposed to X-rays from dental equipment, and found that X-ray exposure leads to cellular damage and apoptosis. This information highlights the importance of implementing protection mechanisms for personnel regularly using this equipment in the field of dentistry.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Biology
Mahmoud I. Khalil, Alaa F. Agamy, Salma S. Elshewemi, Ahmed S. Sultan, Nabila E. Abdelmeguid
Summary: This study investigated the effect of PTE on HepG2 cells and found that PTE can suppress cell proliferation and survival, induce apoptosis, and alter cellular ultrastructure morphology and expression of key proteins.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Natalia Glatzel-Plucinska, Katarzyna Ratajczak-Wielgomas, Katarzyna Nowinska, Sylwia Borska
Summary: Resveratrol may have anticarcinogenic effects by inhibiting human pancreatic cancer cell proliferation and affecting the levels of Bcl-2 proteins. However, its activity is specific to each tested cell line, with the most significant changes observed in the mitoxantrone-resistant cells.
Article
Immunology
Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng
Summary: The study reveals that MO infection induces time-dependent apoptosis in cultured MH-S cells, activating caspase-8-dependent extrinsic pathway and p53- and ROS-dependent intrinsic mitochondrial pathways. MO infection also enhances transcription and translation of proinflammatory cytokine genes, suggesting a potential link between MO-induced inflammation and apoptotic cell death.
Review
Immunology
Ling Qi, Li Wang, Mengru Jin, Mingxia Jiang, Lisha Li, Yanjing Li
Summary: Caspase-6, a member of the caspase family, plays a vital role in mediating cell death. Recent studies have shown that it mediates PANoptosis and is involved in tumorigenesis and anti-tumor immunity. Understanding the function of caspase-6 in PANoptosis is important for cancer prevention and treatment.
Article
Pharmacology & Pharmacy
Liliana-Roxana Balahura, Sorina Dinescu, Mihaela Balas, Alexandra Cernencu, Adriana Lungu, George Mihail Vlasceanu, Horia Iovu, Marieta Costache
Summary: The study demonstrates that embedding 5-FU in P.CNF hydrogels can effectively inhibit breast tumor cell growth, induce pyroptosis, and promote the release of caspase-1 and generation of ROS.
Article
Biology
Joshua D. Greenlee, Maria Lopez-Cavestany, Nerymar Ortiz-Otero, Kevin Liu, Tejas Subramanian, Burt Cagir, Michael R. King
Summary: This study demonstrates that oxaliplatin-resistant CRC cells become more sensitive to TRAIL-mediated apoptosis due to increased DR4 expression, palmitoylation, and translocation. The alteration of DR4/raft colocalization and TRAIL sensitivity by raft perturbation via nystatin and resveratrol is significant. Additionally, treatment with TRAIL liposomes in blood samples from metastatic CRC patients results in a reduction of viable CTCs, with increased DR4/lipid raft colocalization corresponding to increased oxaliplatin resistance and efficacy of TRAIL liposomes.
Article
Biotechnology & Applied Microbiology
Razieh Dehghan, Fatemeh Bahreini, Rezvan Najafi, Massoud Saidijam, Razieh Amini
Summary: Combination therapy using ZER and 5-FU showed promising results in reducing proliferation, migration, colony formation, and survival rates of CRC cells, with the most significant effects observed in the 5-FU+ZER treatment group.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Fatemeh Zomorodi Anbaji, Seyed Jalal Zargar, Saeed Tavakoli
Summary: This study aimed to isolate and evaluate the antineoplastic potential of grandivittin (GRA) in human lung cancer A549 cells. The results showed that GRA induced apoptosis in a dose- and time-dependent manner and decreased cell viability. The expression of apoptotic genes (caspase 3, caspase 9, Bax, P53) was upregulated, while Bcl2 was downregulated after GRA treatment. Therefore, GRA may be a potential new therapeutic agent for the treatment of lung cancer.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Oncology
Grace Fangmin Tan, Shane Goh, Abner Herbert Lim, Wei Liu, Jing Yi Lee, Vikneswari Rajasegaran, Xin Xiu Sam, Timothy Kwang Yong Tay, Sathiyamoorthy Selvarajan, Cedric Chuan-Young Ng, Bin Tean Teh, Jason Yongsheng Chan
Summary: Giant cells (GC) in angiosarcoma may contribute to tumor heterogeneity and treatment resistance, with higher GC content associated with poorer chemotherapy responses and worse overall prognosis in patients with angiosarcoma.
Letter
Medicine, General & Internal
Ki Wei Tan, Jason Yongsheng Chan
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hian Liang Huang, Pei Ing Ngam, Khee Ming Tan, David Chee Eng Ng, Soon Thye Lim, Jason Yongsheng Chan
Summary: This study aimed to investigate the prognostic utility of FDG-PET/CT and its role in complementing clinical indices in NKTCL patients. The results showed that a higher initial SUVmax was significantly associated with advanced disease stage, elevated LDH levels, and plasma EBV DNA detection. A Deauville score of 5 was found to be a more accurate indicator of disease progression, while the NABS score could be used for further risk stratification in patients with Deauville scores of 1-3.
ANNALS OF NUCLEAR MEDICINE
(2021)
Correction
Oncology
Jing Quan Lim, Dachuan Huang, Tiffany Tang, Daryl Tan, Yurike Laurensia, Rou-Jun Peng, Esther Kam Yin Wong, Daryl Ming Zhe Cheah, Burton Kuan Hui Chia, Jabed Iqbal, Nicholas Francis Grigoropoulos, Maarja-Liisa Nairismagi, Cedric Chuan Young Ng, Vikneswari Rajasegaran, Huangming Hong, Seok Jin Kim, Junhun Cho, Eric Tse, Benjamin Mow, Qi-Chun Cai, Li-Mei Poon, Qing-qing Cai, Jing Tan, Jason Yongsheng Chan, Johnathan Xiande Lim, Yeow Tee Goh, Colin Phipps, Olaf Rotzschke, Chee Leong Cheng, Jeslin Chian Hung Ha, Lay Poh Khoo, Yvonne Su Ming Loh, Rex Au-Yeung, Thomas Sau-Yan Chan, Yok-Lam Kwong, William Hwang, Won Seog Kim, Jin-Xin Bei, Tongyu Lin, Choon Kiat Ong, Soon Thye Lim
Article
Pharmacology & Pharmacy
Chia Jie Tan, Rajneesh Kumar, Narendran Koomanan, Wei Sheng Loo, Mohamad Farid, Miriam Tao, Nagavalli Somasundaram, Eileen Poon, Jason Yongsheng Chan, Valerie Shiwen Yang, Esther Chang, Soon Thye Lim, Wan Cheng Chow, Alexandre Chan, Tiffany Tang
Summary: The surveillance protocol for managing HBV reactivation among lymphoma patients receiving rituximab is effective, feasible, and cost-saving, with no reactivation-related events detected in the study.
Article
Oncology
Jing Yuan Tan, Tian Yu Qiu, Jianbang Chiang, Ya Hwee Tan, Valerie Shiwen Yang, Esther Wei Yin Chang, Eileen Poon, Nagavalli Somasundaram, Mohamad Farid, Miriam Tao, Soon Thye Lim, Jason Yongsheng Chan
Summary: We analyzed the prognostic factors for adult Burkitt lymphoma patients and found that the overall prognosis is good, with similar outcomes for patients with and without HIV. The presence of central nervous system disease, bone marrow involvement, and elevated LDH levels are associated with poorer prognosis.
LEUKEMIA & LYMPHOMA
(2023)
Article
Oncology
Abner Herbert Lim, Jason Yongsheng Chan, Ming-Chin Yu, Tsung-Han Wu, Jing Han Hong, Cedric Chuan Young Ng, Zhen Jie Low, Wei Liu, Rajasegaran Vikneswari, Pin-Cheng Sung, Wen-Lang Fan, Bin Tean Teh, Sen-Yung Hsieh
Summary: This study investigates the prevalence and role of Aristolochic acid (AA) in tumorigenesis of oro-gastrointestinal tract cancers (OGITCs). The rarity of AA mutational signatures in OGITCs suggests that AA is unlikely to be a major driver of tumorigenesis in this specific type of cancer.
Article
Genetics & Heredity
Elizabeth Lee, Peiyong Guan, Abner Herbert Lim, Jui Wan Loh, Grace Fangmin Tan, Tracy Loh, Dave Yong Xiang Ng, Jing Yi Lee, Shane Goh, Wei Liu, Cedric Chuan-Young Ng, Bin Tean Teh, Jason Yongsheng Chan
Summary: This study provides the initial molecular description of sarcomatoid renal cell carcinoma (sRCC) arising in the setting of Autosomal dominant polycystic kidney disease (ADPKD). Common pro-oncogenic signals are observed between ADPKD and sRCC, shedding light on their shared pathobiology.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Oncology
Yu Tung Lo, Vivian Yujing Lim, Melissa Ng, Ya Hwee Tan, Jianbang Chiang, Esther Wei Yin Chang, Jason Yongsheng Chan, Eileen Yi Ling Poon, Nagavalli Somasundaram, Mohamad Farid Bin Harunal Rashid, Miriam Tao, Soon Thye Lim, Valerie Shiwen Yang
Summary: The study explores the prognostic value of hematological indices in primary central nervous system lymphomas (PCNSLs) and the impact of corticosteroids on these indices. It suggests that post-steroid NLR, when considered together with baseline NLR, can be a useful prognostic tool for accurate stratification of patients into different risk profiles related to survival outcomes.
Article
Oncology
Dave Yong Xiang Ng, Zhimei Li, Elizabeth Lee, Jessica Sook Ting Kok, Jing Yi Lee, Joanna Koh, Cedric Chuan-Young Ng, Abner Herbert Lim, Wei Liu, Sheng Rong Ng, Kah Suan Lim, Xi Xiao Huang, Jing Han Hong, Peiyong Guan, Yirong Sim, Aye Aye Thike, Nur Diyana Md Nasir, Shang Li, Puay Hoon Tan, Bin Tean Teh, Jason Yongsheng Chan
Summary: This study established a new model for malignant phyllodes tumors and provided evidence for the clinical efficacy of pazopanib in treating malignant phyllodes tumors.
Review
Biochemistry & Molecular Biology
Jing Yi Lee, Bavani Kannan, Boon Yee Lim, Zhimei Li, Abner Herbert Lim, Jui Wan Loh, Tun Kiat Ko, Cedric Chuan-Young Ng, Jason Yongsheng Chan
Summary: This review emphasizes the importance of investigating the tumor microenvironment and cellular heterogeneity in predicting immunotherapy outcomes. It summarizes the application and limitations of conventional technologies and biomarkers for this purpose, and discusses how emerging single-cell spatial omics can advance our understanding of interactions within the tumor microenvironment and aid in biomarker discovery for improving patient response prediction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jason Yongsheng Chan, Elizabeth Chun Yong Lee, Zhimei Li, Jing Yi Lee, Abner Herbert Lim, Eileen Poon
Summary: We established a new patient-derived xenograft (PDX) and cell line model of imatinib-resistant DFSP with fibro-sarcomatous transformation. Whole genome sequencing and RNA sequencing identified gene alterations associated with DFSP and highlighted potential targetable signaling pathways. In cell experiments, certain antiangiogenic agents and a third-generation irreversible EGFR tyrosine kinase inhibitor exhibited modest anti-proliferative activity.
Article
Hematology
Grace Fangmin Tan, Siting Goh, Esther Wei Yin Chang, Ya Hwee Tan, Jianbang Chiang, Valerie Shiwen Yang, Eileen Yi Ling Poon, Nagavalli Somasundaram, Mohamad Farid Bin Harunal Rashid, Miriam Tao, Soon Thye Lim, Choon Kiat Ong, Jason Yongsheng Chan
Summary: Our study examines the prognostic value of immunologic changes in Hodgkin's lymphoma by investigating post-treatment lymphocyte count (pALC), neutrophil count (pANC), and the neutrophil-lymphocyte ratio (pNLR). We analyzed patients treated for classical Hodgkin's lymphoma and determined the optimal cutoff values for high pANC, low pALC, and high pNLR in predicting progression-free survival.
HEMATOLOGY REPORTS
(2023)
Article
Oncology
Jui Wan Loh, Abner Herbert Lim, Jason Yongsheng Chan, Yoon-Sim Yap
Summary: This study investigated the molecular features of non-metastatic HER2-negative breast cancers in relation to ERBB2 copy number alteration (CNA) status, revealing biological differences. Aberrations in other genes on chromosome 17 have important implications for ERBB2 non-neutral breast cancers.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Cell Biology
Josephine Hendrikson, Ying Liu, Wai Har Ng, Jing Yi Lee, Abner Herbert Lim, Jui Wan Loh, Cedric C. Y. Ng, Whee Sze Ong, Joey Wee-Shan Tan, Qiu Xuan Tan, Gillian Ng, Nicholas B. Shannon, Weng Khong Lim, Tony K. H. Lim, Clarinda Chua, Jolene Si Min Wong, Grace Hwei Ching Tan, Jimmy Bok Yan So, Khay Guan Yeoh, Bin Tean Teh, Claramae Shulyn Chia, Khee Chee Soo, Oi Lian Kon, Iain Beehuat Tan, Jason Yongsheng Chan, Melissa Ching Ching Teo, Chin-Ann J. Ong
Summary: This study demonstrates the importance of the STAT3 signaling pathway in peritoneal carcinomatosis and identifies potential activating ligands. The study also validates the prognostic biomarker panel, including PAI-1, and highlights a therapeutic opportunity based on paracrine addiction.
CELL REPORTS MEDICINE
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
