Journal
CANCER LETTERS
Volume 273, Issue 1, Pages 1-14Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.05.032
Keywords
Semaphorin; Neuropilin; Plexin; VEGF; Angiogenesis; Lung cancer
Categories
Funding
- La Ligue Contre le Cancer
- Association pour la Recherche sur le Cancer
- Colorado/MUSC Lung Cancer SPORE [CA58187]
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Semaphorins are a large family of secreted, transmembrane and GPI-linked proteins initially characterized in the development of the nervous system and axonal guidance. Semaphorins are expressed in many tissues where they regulate normal development, organ morphogenesis, immunity and angiogenesis. They affect the cytoskeleton, actin filament organization, microtubules and cell adhesion. Semaphorin signaling is transduced by plexins, which in the case of most class-3 semaphorins requires high-affinity neuropilin receptors. The neuropilins also function as receptors for VEGF and other growth factors, and their expression is often abnormal in tumors. In cancer, semaphorins have both tumor suppressor and tumor promoting functions. We review here the current status of semaphorins and their receptors in tumor development with a focus on lung cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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