Journal
CANCER LETTERS
Volume 280, Issue 1, Pages 61-64Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.02.006
Keywords
Nestin; Cancer stem cell; Anaplastic thyroid carcinoma; Thyroid transcription factor-1; Gene expression
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20590570]
- Princess Takamatsu Cancer Research Fund [04-23606]
- Grants-in-Aid for Scientific Research [20590570, 21590625] Funding Source: KAKEN
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Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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