Article
Chemistry, Multidisciplinary
Shi-Wei Huang, Chih-Ming Pan, Yu-Chuan Lin, Mei-Chih Chen, Yeh Chen, Chia-Ing Jan, Chung-Chun Wu, Fang-Yu Lin, Sin-Ting Wang, Chen-Yu Lin, Pei-Ying Lin, Wei-Hsaing Huang, Yu-Ting Chiang, Wan-Chen Tsai, Ya-Hsu Chiu, Ting-Hsun Lin, Shao-Chih Chiu, Der-Yang Cho
Summary: HLA-G is an immune checkpoint protein and a tumor-associated antigen. Previous research has shown the potential of using CAR-NK targeting HLA-G to treat certain solid tumors. However, co-expression of PD-L1 and HLA-G and up-regulation of PD-L1 after immunotherapy may reduce the effectiveness of HLA-G-CAR. Therefore, a multi-specific CAR targeting both HLA-G and PD-L1 could provide a solution.
Article
Immunology
Mei Xia, Azra Blazevic, Andrew Fiore-Gartland, Daniel F. Hoft
Summary: In this study, the effects of BCG vaccination on γδ T cell responses were investigated. TCR repertoire sequencing revealed minimal changes in the diversity and distribution of TCR clones after vaccination, but identified specific clonotypes that significantly expanded or contracted. These findings provide new insights into the role of γδ T cells in Mycobacterium tuberculosis immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Quincy Chu
Summary: This review summarises the pathobiological role of mesothelin and the current data on therapeutic antibodies targeting mesothelin in solid tumors. Mesothelin is highly expressed in certain types of cancer and is responsible for tumor proliferation, metastasis, resistance to treatment, and evasion of the immune system. Various approaches, including antibodies, antibody drug conjugates, and bispecific antibodies with immune checkpoints, have been investigated for targeting mesothelin in malignancies expressing this protein.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Oncology
Emilie Barsac, Carolina de Amat Herbozo, Loic Gonzalez, Thomas Baranek, Thierry Mallevaey, Christophe Paget
Summary: This review highlights the emerging role of unconventional T cells in tumor immunity, focusing on their protumoral functions and the factors in the tumor microenvironment shaping and controlling these deleterious properties. Unconventional T cells like gamma delta T cells, natural killer T (NKT) cells, and mucosal-associated invariant T (MAIT) cells span the innate-adaptive continuum and possess unique abilities to rapidly react to nonpeptide antigens. The potential therapeutic implications of targeting these unconventional T cell subsets in solid cancers are discussed, along with the need for further feasibility studies in this area.
Article
Multidisciplinary Sciences
Alexey V. Stepanov, Roman S. Kalinin, Victoria O. Shipunova, Ding Zhang, Jia Xie, Yuri P. Rubtsov, Valeria M. Ukrainskaya, Alexey Schulga, Elena V. Konovalova, Dmitry V. Volkov, Igor A. Yaroshevich, Anastasiia M. Moysenovich, Alexey A. Belogurov, Hongkai Zhang, Georgij B. Telegin, Alexandr S. Chernov, Mikhail A. Maschan, Stanislav S. Terekhov, Peng Wu, Sergey M. Deyev, Richard A. Lerner, Alexander G. Gabibov, Sidney Altman
Summary: The development of chimeric antigen receptor (CAR) T cell therapy is an important milestone in modern cancer treatment. However, the safety and efficacy of CAR T cell therapy against solid tumors are challenging. This study adopted the high affinity and capability of the bacterial toxin-antitoxin barnase-barstar system to guide CAR T cells to solid tumors, providing a switchable targeting approach for precise control of CAR T cell cytotoxicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo
Summary: This article summarizes the current knowledge of the γδT cell phenotype in various tissues in mice and humans, describing the similarities and differences of tissue-resident γδT cells in these two species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gisela Gordino, Sara Costa-Pereira, Patricia Corredeira, Patricia Alves, Luis Costa, Anita Q. Gomes, Bruno Silva-Santos, Julie C. Ribot
Summary: The research identified miR-181a as a key regulator of human gamma delta T cell differentiation, with its overexpression leading to reduced levels of NKG2D and TNF-alpha. This highlights the potential of miR-181a in manipulating gamma delta T cells for next-generation immunotherapies.
Article
Oncology
Yan Zou, Bo Liu, Long Li, Qinan Yin, Jiaxing Tang, Zhengyu Jing, Xingxu Huang, Xuekai Zhu, Tian Chi
Summary: Knocking out transcription factor IKZF3 enhances the killing effect of CAR T cells on solid tumors, leading to increased T cell activation and proliferation. The strategy of IKZF3 KO may improve the efficacy of CAR T cells in treating solid tumors.
Article
Biochemistry & Molecular Biology
Jason J. Luke, Manish R. Patel, George R. Blumenschein, Erika Hamilton, Bartosz Chmielowski, Susanna V. Ulahannan, Roisin M. Connolly, Cesar A. Santa-Maria, Jie Wang, Shakeela W. Bahadur, Andrew Weickhardt, Adam S. Asch, Girish Mallesara, Philip Clingan, Monika Dlugosz-Danecka, Monika Tomaszewska-Kiecana, Halyna Pylypenko, Nada Hamad, Hedy L. Kindler, Bradley J. Sumrow, Patrick Kaminker, Francine Z. Chen, Xiaoyu Zhang, Kalpana Shah, Douglas H. Smith, Anushka De Costa, Jonathan Li, Hua Li, Jichao Sun, Paul A. Moore
Summary: Tebotelimab, a bispecific PD-1xLAG-3 DART molecule, was investigated for clinical safety and activity in patients with solid tumors or hematologic malignancies. It showed promising outcomes in PD-1-refractory disease and CAR-T refractory non-Hodgkin lymphomas, suggesting its therapeutic potential in these patient populations.
Article
Immunology
Desislava Yanakieva, Lena Vollmer, Andreas Evers, Vanessa Siegmund, Paul Arras, Lukas Pekar, Achim Doerner, Bernhard Valldorf, Harald Kolmar, Stefan Zielonka, Simon Krah
Summary: In this study, a novel symmetric bispecific antibody format was presented by grafting cattle-derived knob paratopes onto peripheral loops of the IgG1 Fc region. Knob architectures obtained from bovine ultralong CDR-H3 antibodies were inserted into the AB loop or EF loop of the CH3 domain to introduce an artificial binding specificity into an IgG molecule. The generated bispecific antibodies demonstrated retained binding affinities of the inserted knob domains and versatile effector cell redirection functionalities without compromising Fc mediated functions such as FcRn or Fc gamma RIIIa binding.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Liu Liu, Xi Chen, Yi Lu, Xiao-Ying Sun, Kan Ze, Ya-Qiong Zhou, Wei Li, Xin Li, Hong-Jin Li, Bin Li
Summary: Cel gel reduces IL-23 secretion and inhibits the interaction between LCs and γδT cells to alleviate psoriasis. It also shows a glucocorticoid-like effect, which can prevent recurrence.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Mary Ellen Molloy, Richard J. Austin, Bryan D. Lemon, Wade H. Aaron, Vaishnavi Ganti, Adrie Jones, Susan D. Jones, Kathryn L. Strobel, Purbasa Patnaik, Kenneth Sexton, Laurie Tatalick, Timothy Z. Yu, Patrick A. Baeuerle, Che-Leung Law, Holger Wesche
Summary: HPN536, a trispecific T-cell-activating protein-based construct targeting MSLN-expressing tumor cells, showed potent pharmacologic activity, good tolerability, and extended half-life in nonhuman primates. It is currently undergoing phase I clinical testing for patients with MSLN-expressing malignancies.
CLINICAL CANCER RESEARCH
(2021)
Review
Immunology
Guangna Liu, Wei Rui, Xueqiang Zhao, Xin Lin
Summary: CAR-T cell therapy has shown successful outcomes in hematological malignancies but faces challenges in treating solid tumors due to immunosuppressive mechanisms in the tumor microenvironment. This review summarized inhibitory factors affecting CAR-T cell function and discussed strategies to enhance CAR-T cell efficacy in solid tumor treatment by targeting these barriers.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung-min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt, B. Brooke Solarz, Maria Fergusson, Sharon A. Mavroukakis, Anjum Zaki, Kwong Y. Tsang, Philip M. Arlen, Christina M. Annunziata
Summary: NEO-201 is a humanized mAb generated against tumor-associated antigens in patients with colorectal cancer. The phase I trial showed that NEO-201 was safe and well tolerated, with neutropenia being the most common adverse event. The study also observed a reduction in the percentage of regulatory T cells after NEO-201 treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Alison Crawford, Danica Chiu
Summary: Immunotherapies for cancer treatment have progressed significantly in the past decade, with a focus on T cell-directed therapies such as CD3 bispecific antibodies and CAR T cells. However, the application of these therapies to solid tumors remains a challenge, with ongoing research needed to overcome resistance mechanisms.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Pathology
Hongbo Hu, Wenwen Peng, Qiaoying Peng, Ying Cheng
Summary: This study determined the prevalence and relationship of gB, gN, and gH genotypes of CMV in CMV-associated thrombocytopenia (CAP). The gH2 genotype of CMV may be potentially associated with infantile thrombocytopenia.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hai-Ning Chen, Yang Shu, Fei Liao, Xue Liao, Hongying Zhang, Yun Qin, Zhu Wang, Maochao Luo, Qiuluo Liu, Zhinan Xue, Minyuan Cao, Shouyue Zhang, Wei-Han Zhang, Qianqian Hou, Xuyang Xia, Han Luo, Yan Zhang, Lie Yang, Jian-Kun Hu, Xianghui Fu, Bo Liu, Hongbo Hu, Canhua Huang, Yong Peng, Wei Cheng, Lunzhi Dai, Li Yang, Wei Zhang, Biao Dong, Yuan Li, Yuquan Wei, Heng Xu, Zong-Guang Zhou
Summary: The study provides insights into the genomic evolution and metastatic patterns of colorectal cancer, suggesting that biopsy/sequencing of metastases should be considered for patients with multiorgan or late postoperative metastasis.
Article
Pathology
Xiao-peng Shang, Jian-gang Wu, Ying Cheng, Hong-bo Hu
Summary: The study found that streptococcal infection is one of the most common pathogens causing HSP in children, with certain epidemiological characteristics, and can cause renal involvement and affect immune function.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chong Zhao, Yuhan Fu, Xuan Ma, Shuang Zhao, Han Zhang, Shutao Yin, Hongbo Hu
Summary: Ample evidence has shown that autophagy plays an important role in hepatotoxicity, either as a protective mechanism or a cause for hepatotoxicity. The functional role of autophagy in the pathogenesis of hepatotoxicity has been gradually recognized, and targeting autophagy as a novel strategy has shown promising efficacy in various models.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Weigang Wang, Sisi Yu, Wenjing Li, Hongbo Hu, Guofang Zou
Summary: The study found that lncRNA SNHG17 is upregulated in epithelial ovarian cancer (EOC), and its silencing inhibits the development of EOC by regulating the miR-485-5p/AKT1 axis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Geology
Jiateng Guo, Jiangmei Wang, Lixin Wu, Wancheng Zhu, Mark Jessell, Chaoling Li, Fengdan Li, Hongbo Hu
Summary: This paper proposes an automatic update algorithm for 3D geological body models based on an implicit function and geostatistics. The algorithm successfully updates the ore body model rapidly and effectively, resulting in smooth and topologically error-free models.
ORE GEOLOGY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Xuan Ma, Hui Chen, Lixing Cao, Shuang Zhao, Chong Zhao, Shutao Yin, Lihong Fan, Hongbo Hu
Summary: Ferroptosis is involved in neurodegenerative diseases, and 18b-glycyrrhetinic acid (GA) has a neuroprotective effect by inhibiting cellular labile iron accumulation and up-regulating coenzyme Q10 (CoQ10) levels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pathology
Hong-Bo Hu, Xiao-Peng Shang, Jian-Gang Wu, Ya-Ling Cai
Summary: In this study, the immunologic characteristics of mycoplasma pneumoniae-triggered Kawasaki disease (MP-KD) were compared with Kawasaki disease (KD) not associated with mycoplasma pneumoniae (MP), mycoplasma pneumoniae-triggered Henoch-Schonlein purpura (MP-HSP), and healthy controls. The results showed that complement C3 and CD4/CD8 ratio were significantly higher in the MP-KD group compared to the KD group. The MP-KD group also exhibited higher levels of C3, C4, and CD4/CD8 ratio compared to the MP-HSP group, while IgA and CD56 levels were lower.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Han Luo, Xuyang Xia, Li-Bin Huang, Hyunsu An, Minyuan Cao, Gyeong Dae Kim, Hai-Ning Chen, Wei-Han Zhang, Yang Shu, Xiangyu Kong, Zhixiang Ren, Pei-Heng Li, Yang Liu, Huairong Tang, Ronghao Sun, Chao Li, Bing Bai, Weiguo Jia, Yi Liu, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Yiguo Hu, Jingqiang Zhu, Hong Jiang, Zhihui Li, Carlos Caulin, Jihwan Park, Heng Xu
Summary: This study conducts pan-cancer analysis on 226 samples across 10 solid cancer types, illustrating the commonalities and plasticity of heterogeneous CAFs. It reveals that the activation trajectory of major CAF types is divided into three states, showing distinct interactions with other cell components and correlation with immunotherapy prognosis. Additionally, minor CAF components may originate from other TME components such as endothelial cells and macrophages.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Oncology
Yijia Du, Qian Chu, Yanyan Lou, Yong He, Hongbo Hu, Qipeng Hu, Meijuan Huang
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Shuang Zhao, Jinling Cui, Lixing Cao, Kai Han, Xuan Ma, Hui Chen, Shutao Yin, Chong Zhao, Changwei Ma, Hongbo Hu
Summary: In this study, xanthohumol was found to inhibit the cell proliferation, migration, and invasion of non-small cell lung cancer (NSCLC) by directly interacting with T-lymphokine-activated killer cell-originated protein kinase (TOPK) and inactivating it. These findings provide new insight into the mechanisms underlying the anticancer activity of xanthohumol.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Xiaoqi Han, Siyuan Jiang, Yinmin Gu, Lihua Ding, Enhao Zhao, Dongxing Cao, Xiaodong Wang, Ya Wen, Yongbo Pan, Xin Yan, Liqiang Duan, Minxuan Sun, Tao Zhou, Yajuan Liu, Hongbo Hu, Qinong Ye, Shan Gao
Summary: In this study, it was found that HUNK inhibits EMT and metastasis of CRC cells through its kinase-dependent interaction with GEF-H1. HUNK directly phosphorylates GEF-H1 at serine 645, leading to activation of RhoA and subsequent phosphorylation of LIMK-1/CFL-1, resulting in stabilization of F-actin and inhibition of EMT. Clinically, decreased levels of HUNK expression and phosphorylation of GEF-H1 at serine 645 were observed in CRC tissues with metastasis, indicating their potential as biomarkers for metastasis.
CELL DEATH & DISEASE
(2023)
Article
Microbiology
Dan Lu, Ying Cheng, Hongbo Hu
Summary: This study investigated the prevalence of co-infections in hospitalized children with Parainfluenza Virus type 3 (PIV3) infection and their role in Acute Respiratory Infection (ARI). The results showed that 34.0% of PIV3 infections had co-infection with other pathogens, with Mycoplasma pneumoniae being the most common co-infecting pathogen. Co-infections with Mycoplasma pneumoniae were more common in girls and in patients aged 1-2 years, while viral and bacterial co-infections occurred mainly in children younger than one year. Co-infections with Mycoplasma pneumoniae, bacterial co-infections, and co-infections with more than two pathogens prolonged hospitalization.
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Jie Zhou, Xiang Cai Wei, Hong Yan Xu, Hong Bo Hu, Fan Xiang Li, Wei Juan Zhou, Ye Chen, Zhen Liu
Summary: This study found a U-shaped relationship between blood glucose levels and multiple HPV infections, indicating that both high and low blood glucose levels increase the risk of multiple HPV infections.
Article
Immunology
Jinyuan Luoqian, Wenyong Yang, Xulong Ding, Qing-zhang Tuo, Zheng Xiang, Zhaoyue Zheng, Yu-jie Guo, Li Li, Pengbo Guan, Scott Ayton, Biao Dong, Huiyuan Zhang, Hongbo Hu, Peng Lei
Summary: This study discovered a potential role of ferroptosis, an iron-dependent regulated cell death mechanism, in multiple sclerosis (MS), and proposed the possibility of targeting ferroptosis for MS treatment.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.