Article
Multidisciplinary Sciences
Ryo Shimada, Yuki Tatara, Kazuhiko Kibayashi
Summary: Meningeal lymphatic vessels can be damaged by traumatic brain injury (TBI), which affects brain function. In a mouse model of TBI, it was observed that the number of meningeal lymphatic endothelial cells (LECs) decreased, the mRNA expression of a specific marker of lymphatic vessels decreased, and the mRNA and protein expression of markers of lymphangiogenesis increased.
Article
Medicine, Research & Experimental
Jian Chen, Fan Zhang, Mengmeng Hua, Xiaobin Song, Shaohua Liu, Zuoqing Dong
Summary: This study demonstrated a significant association between intratumoral lymphatic vessel density (ILVD) and increased lymphatic metastasis, tumor recurrence, and reduced disease-specific survival in patients with oral squamous cell carcinoma. ILVD could be considered as an indicator for predicting the prognosis of OSCC.
Article
Multidisciplinary Sciences
Shira Landau, Abigail Newman, Shlomit Edri, Inbal Michael, Shahar Ben-Shaul, Yulia Shandalov, Tom Ben-Arye, Pritinder Kaur, Ming H. Zheng, Shulamit Levenberg
Summary: Lymphatic system plays a critical role in various biological processes, yet lymphangiogenesis is less studied compared to angiogenesis. By culturing human lymphatic endothelial cells on thick collagen sheets with supporting cells and blood endothelial cells, a functional lymphatic vessel network was successfully developed in a short period of time. The model provides a potential platform for investigating lymphangiogenesis and lymphatic disease mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Jing-Yun Wen, Xing Li, Jian-Ning Chen, Jie Chen, Jing-Yue Zhang, Yu Du, Wei-Hang Zhu, Yong-Jian Chen, Ri-Hong Yang, Chun-Kui Shao
Summary: CD45(-) EPCs are found to be accumulated in GC tissues and metastatic LNs and promote LN metastasis through the S100A8/9-induced hybrid E/M state of LECs, which is the specific mechanism of LN metastasis in the early stages of GC. CD45(-) EPCs can predict the overall and disease-free survival of stage I-III GC patients after radical resection.
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Review
Physiology
Faisal Masood, Rohan Bhattaram, Mark Rosenblatt, Andrius Kazlauskas, Jin-Hong Chang, Dimitri T. Azar
Summary: Aberrant lymphatic system function is linked to various pathologies, and while lymphatic vessel regression and dysfunction can worsen some conditions, induced regression may be beneficial in certain cases. However, our understanding of lymphatic vessel regression lags behind that of blood vessel regression. By studying blood vessel regression, we can uncover hallmarks of this phenomenon that could help us better understand lymphatic vessel regression. Current research tools and models can be utilized to advance this field and gain therapeutic insights into select pathologies.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger
Summary: This study reveals that activating KRAS mutations disrupt KRAS/MAPK signaling during embryonic development, leading to impaired lymphovenous valve formation and lymphatic vessel enlargement. The use of the MEK1/2 inhibitor trametinib restores normal lymphatic vessel development. These findings support the potential of MEK1/2 inhibitors for treating CLAs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Joshua S. T. Hooks, Fabrice C. Bernard, Ricardo Cruz-Acuna, Zhanna Nepiyushchikh, Yarelis Gonzalez-Vargas, Andres J. Garcia, J. Brandon Dixon
Summary: The lymphatic vasculature plays a crucial role in the body's circulation system, and studying its growth mechanisms and developing related biomaterial strategies is of great importance. Utilizing an engineered hydrogel material, the sprouting and transplantation of lymphatic vessels can be facilitated, providing a promising platform for further research on lymphangiogenesis.
Article
Multidisciplinary Sciences
Zhenyuan Li, Tailiang Lu, Zhian Chen, Xiang Yu, Lingzhi Wang, Guodong Shen, Huilin Huang, Zhenhao Li, Yingxin Ren, Weihong Guo, Yanfeng Hu
Summary: Most early stage gastric cancer patients do not have lymph node metastases, but metastases appear in the advanced stage. However, some patients have lymph node metastases in the early stage and none in the advanced stage. To explore the molecular mechanisms involved, clinical samples were collected from patients with early and advanced stage gastric cancer with and without lymph node metastases, as well as metastatic lymph nodes. HOXA11 was identified as a key target that is upregulated in gastric cancer tissues and closely associated with lymphatic metastases. HOXA11 transcriptionally regulates TGF beta 1 expression, activates the TGF beta 1/Smad2 pathway, promotes EMT development, induces VEGF-C secretion, and lymphangiogenesis. These findings provide a plausible mechanism for HOXA11-modulated tumor lymphatic metastasis and suggest HOXA11 as a potential therapeutic target for LN-metastatic gastric cancer.
Article
Peripheral Vascular Disease
Anqi Li, Linyu Zhu, Ningjing Lei, Jiajia Wan, Xixi Duan, Shuangqing Liu, Yanru Cheng, Ming Wang, Zhuoyu Gu, Huilei Zhang, Yueyue Bai, Li Zhang, Fazhan Wang, Chen Ni, Zhihai Qin
Summary: The expression of S100A4 in lymphatic endothelial cells promotes lymphatic vessel sprouting in growing tumors by regulating glycolysis. S100A4 plays a crucial role in the position and motility of tip cells, and its expression is upregulated under hypoxic conditions. These findings suggest that S100A4 is a novel regulator of tumor-induced lymphangiogenesis.
Review
Physiology
Naoto Ujiie, Tsutomu Kume
Summary: The lymphatic system plays a crucial role in maintaining interstitial fluid and protein homeostasis, lipid absorption and transportation in the digestive system, and immune surveillance and response. The development of lymphatic vessels involves various cellular and molecular mechanisms, and the transcriptional regulation in lymphatic vessel development is still poorly understood. This review discusses the recent advances in understanding the molecular and cellular mechanisms of lymphatic vascular development, with a focus on transcriptional regulation, and summarizes the current knowledge on epigenetic mechanisms of lymphatic gene expression.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Thien T. Phan, Adri Chakraborty, Madison A. Tatum, Ana Lima-Orellana, Andrea J. Reyna, Joseph M. Rutkowski
Summary: During cold exposure, white adipose tissue can remodel itself to release heat, similar to brown adipose tissue. The regulation of body temperature in response to cold is controlled by neural and hormonal signaling. It has been discovered that neurotensin, a small neuropeptide, not only inhibits thermogenesis but is also produced by lymphatic vessels. This study found that inducing lymphangiogenesis in adipose tissue increased the levels of neurotensin and impaired thermogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Arinola O. Lampejo, Soheila Ali Akbari Ghavimi, Rene Haegerling, Shailesh Agarwal, Walter L. Murfee
Summary: The lymphatic system has a significant role in maintaining homeostasis, fluid drainage, and is associated with various diseases. New evidence suggests a closer connection between the lymphatic and blood vascular systems. However, there are knowledge gaps regarding lymphatic vascular plasticity, its conditions, and characteristic structures. This review aims to summarize the current understanding of lymphatic plasticity, discuss its potential clinical implications, and encourage further research to explore therapeutic interventions.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cell Biology
Delayna Paulson, Rebecca Harms, Cody Ward, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink
Summary: Microenvironmental signals during development or inflammation can stimulate lymphatic endothelial cells to undergo lymphangiogenesis, a process involving sprouting, proliferation, and migration to expand the vascular network. Primary cilia, microtubule-based cellular protrusions housing specialized membrane receptors and signaling complexes, play a critical role in receiving extracellular cues. Disruption of primary cilia on lymphatic endothelial cells can lead to edema, increased vessel caliber and branching, as well as red blood cell-filled lymphatics, impacting lymphatic vessel patterning during development and inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Sini Karinen, Krista Juurikka, Roosa Hujanen, Wafa Wahbi, Elin Hadler-Olsen, Gunbjorg Svineng, Kari K. Eklund, Tuula Salo, Pirjo Astrom, Abdelhakim Salem
Summary: This study identified lymphatic mimicry as a potential novel mechanism of lymphatic metastasis in oral squamous cell carcinoma, involving the expression and function of LYVE-1. Further studies are needed to better define this phenomenon and its implications for the development of targeted therapeutics targeting cancer-related lymphangiogenesis.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
