Article
Plant Sciences
Ying Feng, Han Dong, Liyan Zheng
Summary: Ligustrazine was found to inhibit inflammation in Endometriosis (EMs) by regulating the STAT3/IGF2BP1/RELA axis. These findings propose a new agent against EMs and support the development of ligustrazine-based treatment strategies for EMs.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Psychiatry
Rajesh Das, Md. Prova Zaman Emon, Mohammad Shahriar, Zabun Nahar, Sardar Mohammad Ashraful Islam, Mohiuddin Ahmed Bhuiyan, Sheikh Nazrul Islam, Md. Rabiul Islam
Summary: The study found that serum IL-1 beta and TNF-alpha levels are increased in MDD patients and are positively correlated with the severity of depression. Elevated levels of serum IL-1 beta and TNF-alpha could potentially be used as risk assessment indicators for depression.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yu-Tsai Lin, Ming-Hsien Tsai, Yan-Ye Su, Wei-Chih Chen, Shun-Chen Huang, Chih-Yen Chien
Summary: This study investigates the expression of Raftlin in cigarette smokers and in chronic rhinosinusitis with nasal polyps (CRSwNP), and finds that increased Raftlin expression in columnar cells might involve nasal epithelial remodeling in smokers with CRSwNP. Additionally, a positive relationship is found between IL-17 and TNF-alpha levels with Raftlin levels.
Review
Immunology
Maha Sellami, Nicola Luigi Bragazzi, Baha Aboghaba, Mohamed A. Elrayess
Summary: This review summarizes the effects of acute and chronic exercise on immunoglobulins and cytokines in the elderly. Acute endurance exercise increases salivary SIgA, while acute muscle strengthening exercise raises levels of IL-6, IL-8, and TNF-alpha. Chronic exercise, both short-term and long-term, leads to improvements in immune function.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Aida Malek Mahdavi, Zeinab Javadivala
Summary: This study systematically reviewed the research on the influence of Coriandrum sativum L. on inflammatory mediators, finding that C. sativum consumption led to a considerable decrease in IL-1 beta, IL-6, and TNF-alpha levels. However, further investigations are needed to assess the impact of C. sativum on other inflammatory factors and the clinical consequences of inflammation-related diseases.
INFLAMMOPHARMACOLOGY
(2022)
Review
Immunology
Aida Malek Mahdavi, Zeinab Javadivala, Yeganeh Khalili, Majid Khalili
Summary: The aim of this systematic review was to gather research on the effect of quinoa on inflammatory parameters. The review included 20 animal and in vitro investigations and found that quinoa administration significantly decreased levels of IL-6, IL-1 beta, and TNF-alpha, indicating its potential in alleviating inflammatory factors.
INFLAMMOPHARMACOLOGY
(2023)
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Pediatrics
Maria K. Hautala, Heli M. Helander, Tytti M-L Pokka, Ulla Koskela, Heikki M. J. Rantala, Matti K. Uhari, Timo J. Korkiamaki, Virpi Glumoff, Kirsi H. Mikkonen
Summary: The role of cytokines in the pathogenesis of febrile seizures (FSs) was explored in this study. The results showed that patients with FSs produced stronger inflammatory reactions during FS episodes. This finding is important for understanding the pathogenesis of FSs.
PEDIATRIC RESEARCH
(2023)
Article
Plant Sciences
Goutami G. Ambati, Kamalender Yadav, Ruchika Maurya, K. K. Kondepudi, Mahendra Bishnoi, Sanjay M. Jachak
Summary: In this study, the anti-inflammatory activity of Gymnosporia montana leaves extracts was evaluated. The hexane extract showed the most effective inhibition of inflammatory mediators, and beta-amyrin was identified as the major bioactive compound. The results indicate the potential of G. montana leaves for the treatment of inflammation and toothache.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Ilias D. Vachliotis, Ioannis Valsamidis, Stergios A. Polyzos
Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing rapidly. The mechanisms of progression from NAFLD to HCC are not fully understood, but tumor necrosis factor-alpha (TNF-alpha) and adiponectin may play a role. TNF-alpha initially aims to protect against hepatocarcinogenesis, but during the progression of NAFLD, TNF-alpha is increased, thus possibly inducing hepatocarcinogenesis. On the other hand, adiponectin, which is expected to have anti-tumorigenic effects, is decreased during the progression of the disease, but paradoxically increased at the end stage when cirrhosis and HCC are present. Both TNF-alpha and adiponectin may serve as diagnostic biomarkers and therapeutic targets in the treatment of NAFLD-associated HCC, possibly in combination with immune checkpoint inhibitors.
Editorial Material
Anesthesiology
A. Ni Eochagain
Summary: The case presented involves a patient who developed cryoshock during a cryoablative procedure for hepatocellular carcinoma. Cryoshock, a rare complication of cryoablation, can lead to multiorgan failure and coagulopathy with a mortality rate of up to 40%. The main mechanism appears to involve cytokine release and the mainstay of treatment is organ support.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Cell Biology
Stefan Teufel, Petra Koeckemann, Christine Fabritius, Lena Wolff, Jessica Bertrand, Thomas Pap, Christine Hartmann
Summary: Agonists and antagonists of the canonical Wnt signaling pathway have an impact on rheumatoid arthritis, primarily modifying bone loss and soft-tissue inflammation. WNT9a levels are elevated in the pannus tissue of RA patients, suggesting a specific role in TNF-triggered RA.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Ming-Ying Lu, Ming-Lun Yeh, Ching- Huang, Shu-Chi Wang, Yi-Shan Tsai, Pei-Chien Tsai, Yu-Min Ko, Ching-Chih Lin, Kuan-Yu Chen, Yu-Ju Wei, Po-Yao Hsu, Cheng-Ting Hsu, Tyng-Yuan Jang, Ta-Wei Liu, Po-Cheng Liang, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu
Summary: Chronic hepatitis C virus (HCV) infection induces changes in cytokine expression, and this study found that downregulation of TNF-alpha significantly increases the risk of hepatocellular carcinoma (HCC) after successful antiviral therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Neurosciences
Qing-Qing Yang, Hao-Nan Li, Yu-Tong Xia, Xue Tian, Fan Feng, Jian Yang, Ya-Li Xu, Juan Guo, Xiao-Qi Li, Jun-Yang Wang, Xiao-Yan Zeng
Summary: Our study reveals that rubral interleukin-6 (IL-6) plays a role in descending facilitation and pain sensation through the activation of JAK2/STAT3 and/or ERK pathways, resulting in the upregulation of spinal pro-inflammatory cytokines and downregulation of spinal anti-inflammatory cytokines. These findings provide potential therapeutic targets for the treatment of pathological pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ayami Saga, Masahiro Koseki, Kotaro Kanno, Jiuyang Chang, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Masumi Asaji, Katsunao Tanaka, Takashi Omatsu, Sae Nishihara, Yinghong Zhu, Kaori Ito, Hiroaki Hattori, Ikuyo Ichi, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Tohru Ohama, Shungo Hikoso, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata
Summary: Patients with psoriasis are more prone to nonalcoholic fatty liver disease. A cholesterol derivative called 7-ketocholesterol (7KC) may exacerbate psoriasis-like dermatitis by accelerating steatohepatitis. These findings suggest a diet-related factor linking steatohepatitis and psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
C. Shimanoe, T. Hachiya, M. Hara, Y. Nishida, K. Tanaka, Y. Sutoh, A. Shimizu, A. Hishida, S. Kawai, R. Okada, T. Tamura, K. Matsuo, H. Ito, E. Ozaki, D. Matsui, R. Ibusuki, I. Shimoshikiryo, N. Takashima, A. Kadota, K. Arisawa, H. Uemura, S. Suzuki, M. Watanabe, K. Kuriki, K. Endoh, H. Mikami, Y. Nakamura, Y. Momozawa, M. Kubo, M. Nakatochi, M. Naito, K. Wakai
GENES BRAIN AND BEHAVIOR
(2019)
Article
Gastroenterology & Hepatology
Yoshimichi Takara, Hiroyoshi Endo, Ryo Nakano, Kojiro Kawachi, Hidenori Hidaka, Takuya Matsunaga, Nanae Tsuruoka, Yasuhisa Sakata, Ryo Shimoda, Megumi Hara, Kazuma Fujimoto
Article
Immunology
Risa Kudo, Manako Yamaguchi, Masayuki Sekine, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Megumi Hara, Sharon J. B. Hanley, Takayuki Enomoto
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Medicine, General & Internal
Norihiro Okamoto, Naoyuki Tominaga, Yasuhisa Sakata, Megumi Hara, Takahiro Yukimoto, Sanae Tsuruta, Kohei Yamanouchi, Eri Takeshita, Keiji Matsunaga, Yoichiro Ito, Koichi Miyahara, Takahiro Noda, Daisuke Yamaguchi, Seiji Tsunada, Yuichiro Tanaka, Hiroharu Kawakubo, Nanae Tsuruoka, Ryo Shimoda, Shinichi Ogata, Kazuma Fujimoto
Article
Peripheral Vascular Disease
Megumi Hara, Yusuke Yakushiji, Kohei Suzuyama, Masashi Nishihara, Makoto Eriguchi, Tomoyuki Noguchi, Masanori Nishiyama, Yusuke Nanri, Jun Tanaka, Hideo Hara
HYPERTENSION RESEARCH
(2019)
Article
Sport Sciences
Yuichiro Nishida, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Mikako Horita, Chisato Shimanoe, Jun Yasukata, Nobuyuki Miyoshi, Yosuke Yamada, Ken Higashimoto, Hidenobu Soejima, Keitaro Tanaka
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2019)
Article
Public, Environmental & Occupational Health
Kaoru Araki, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida, Muneaki Matsuo, Keitaro Tanaka
JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Peripheral Vascular Disease
Rieko Okada, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Sayo Kawai, Takashi Tamura, Asahi Hishida, Hiroaki Ikezaki, Norihiro Furusyo, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Miki Watanabe, Toshiro Takezaki, Daisaku Nishimoto, Daisuke Matsui, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Yoshimasa Nakamura, Sakurako Katsuura-Kamano, Kokichi Arisawa, Haruo Mikami, Yoko Nakamura, Isao Oze, Yuriko N. Koyanagi, Mariko Fujimoto Naito, Kenji Wakai
JOURNAL OF HUMAN HYPERTENSION
(2020)
Article
Immunology
Megumi Hara, Motoki Ishibashi, Atsushi Nakane, Takashi Nakano, Yoshio Hirota
Summary: A survey in Japan revealed that healthcare workers, especially nurses, had lower acceptance rates of the COVID-19 vaccine compared to the general population. Women and young adults were more likely to be hesitant about vaccination, while smokers were more likely to accept it. Nurses showed a higher hesitancy rate compared to the general population.
Review
Immunology
Megumi Kurosawa, Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J. B. Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto
Summary: The preventive effect of HPV vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data, with different durations of effectiveness for different vaccines. The 4-valent vaccine has shown the longest sustained clinical effect, while further observation is needed for the 9-valent vaccine.
Article
Immunology
Mohammad Said Ashenagar, Akiko Matsumoto, Hironori Sakai, Mikiko Tokiya, Megumi Hara, Yoshio Hirota
Summary: This study monitored antibody levels after SARS-CoV-2 vaccination using two different measurement systems, CLEIA and ELISA. The results showed that CLEIA had better sensitivity in the low concentration range, while ELISA was also useful in the high titer range. The study also observed a gender difference in antibody levels after vaccination.
Article
Immunology
Mikiko Tokiya, Megumi Hara, Akiko Matsumoto, Mohammad Said Ashenagar, Takashi Nakano, Yoshio Hirota
Summary: Understanding vaccine hesitancy is crucial in combating the COVID-19 pandemic. This study monitored vaccine hesitancy among the Japanese population during the three phases of vaccine approval and introduction, and examined its association with vaccine confidence and literacy. The findings revealed a transient increase in hesitancy during the introduction phases and changes in perception as the vaccination program progressed or waves of epidemic occurred.
Article
Immunology
Megumi Hara, Takeki Furue, Mami Fukuoka, Kentaro Iwanaga, Eijo Matsuishi, Toru Miike, Yuichiro Sakamoto, Naoko Mukai, Yuki Kinugasa, Mutsumi Shigyo, Noriko Sonoda, Masato Tanaka, Yasuko Arase, Yosuke Tanaka, Hitoshi Nakashima, Shin Irie, Yoshio Hirota
Summary: This study evaluated the effectiveness of two doses of BNT162b2 or mRNA-1273 vaccines against the Delta variant in the Japanese population from June to September 2021. The VE was found to be 92% in June-July and 79% in August-September, and adjusted VE for homestay, hotel-based isolation, and hospitalization was 78%, 77%, and 97%, respectively. Despite a slight decline, VE against hospitalization remained strong for about 3 months after the second dose, indicating the need for longer-term monitoring of VE against new variants in vaccination policymaking.
Article
Immunology
Mikiko Tokiya, Megumi Hara, Akiko Matsumoto, Mohammad Said Ashenagar, Takashi Nakano, Yoshio Hirota
Summary: The study investigated the intentions and readiness for COVID-19 booster vaccination in Japan. Results showed that the majority of participants accepted the booster doses, with factors such as age, marital status, having children, underlying diseases, and social norms being associated with vaccination intention. The 7C vaccination readiness scale was found to be useful for measuring acceptance, with social norms being the strongest predictor. This study highlights the importance of understanding public intentions and readiness for vaccination in developing effective vaccination strategies.
Article
Nutrition & Dietetics
Hinako Nanri, Megumi Hara, Yuichiro Nishida, Chisato Shimanoe, Yun-Shan Li, Hiroshi Kasai, Kazuaki Kawai, Yasuki Higaki, Keitaro Tanaka
Summary: This study aimed to evaluate the association between oxidative balance score (OBS) and urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) among Japanese adults. The findings showed that higher OBSs were significantly associated with lower urinary 8-OHdG levels, suggesting that OBS could be a useful tool for evaluating oxidative stress-related lifestyle factors, including diet.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
