Journal
CANCER JOURNAL
Volume 20, Issue 3, Pages 211-216Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0000000000000043
Keywords
Cancer; stomach; H. pylori; microbiota
Categories
Funding
- National Institutes of Health [AI083127, RR-20136, DK064400]
- Immunology, Autoimmunity and Transplantation Strategic Planning (IAT)
- Crohn's and Colitis Foundation of America
- Research Service of the Veterans Administration
- Basic Mechanism of AIDS Pathogenesis training grant [T32-AI007493]
- School of Medicine, Comprehensive Cancer Center [P30AR050948]
- Center for AIDS Research [5P30AI027767]
- Center for Clinical Translational Science [UL1TR000165]
- Heflin Center
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Cancer of the stomach is the fourth most common cancer worldwide. The single strongest risk factor for gastric cancer is Helicobacter pylori-associated chronic gastric inflammation. Among persons with H. pylori infection, strain-specific components, host immune responses, and environmental factors influence the risk for gastric disease, including adenocarcinoma of the stomach, although only a small proportion of infected persons develop the malignancy. Recent advances in DNA sequencing technology have uncovered a complex community of noncultivatable inhabitants of the human stomach. The interaction between these inhabitants, collectively referred to as the gastric microbiota, and H. pylori likely affects gastric immunobiology and possibly the sequelae of H. pylori infection. Thus, characterization of the gastric microbiota in subjects with and without H. pylori infection could provide new insight into gastric homeostasis and the pathogenesis of H. pylori-associated disease, including gastric cancer.
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