Journal
CANCER INVESTIGATION
Volume 32, Issue 1, Pages 13-21Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2013.861472
Keywords
Fetal lung adenocarcinoma; Lung adenocarcinoma; Vascular endothelial growth factor; Axitinib; Antineoplastic drugs; Cancer primary cell cultures
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Funding
- University of Rome Sapienza
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Fetal lung adenocarcinoma (FLAC) is a rare variant of lung adenocarcinoma. Studies regarding FLAC have been based only on histopathological observations, thus representative in vitro models of FLAC cultures are unavailable. We have established and characterized a human primary FLAC cell culture, exploring its biology, chemosensitivity, and migration. FLAC cells and specimen showed significant upregulation of VEGF(165) and HIF-1 alpha mRNA levels. This observation was confirmed by in vitro chemosensitivity and migration assay, showing that only Axitinib was comparable to Cisplatin treatment. We provide a suitable in vitro model to further investigate the nature of this rare type of cancer.
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