Synthetic Peptides Containing ITIM-Like Domains Block Expression of Inflammatory Mediators and Migration/Invasion of Cancer Cells Through Activation of SHP-1 and PI3K

Synthetic peptides containing ITIM-like sequences of IREM-1 inhibit BAFF-mediated regulation of interleukin-8 expression and phagocytosis through SHP-1 and/or PI3K

(2011) Sang-Min Lee et al.   IMMUNOLOGY

CD300F Blocks Both MyD88 and TRIF-Mediated TLR Signaling through Activation of Src Homology Region 2 Domain-Containing Phosphatase 1

(2011) S.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

Cooperation of TLR2 with MyD88, PI3K, and Rac1 in Lipoteichoic Acid–Induced cPLA2/COX-2–Dependent Airway Inflammatory Responses

(2010) I-Ta Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

A preferential p110α/γ PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-κB-dependent manner

(2010) Nilesh M. Dagia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells

(2010) Seung-Hee Lee et al.   CELLULAR IMMUNOLOGY

Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK)

(2010) S.-M. Lee et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Stimulation of FasL Induces Production of Proinflammatory Mediators Through Activation of Mitogen-Activated Protein Kinases and Nuclear Factor-κB in THP-1 Cells

(2010) Sang-Min Lee et al.   INFLAMMATION

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1

(2009) Hongkang Xi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Activating and Inhibitory Signal from an Inhibitory Receptor LMIR3/CLM-1: LMIR3 Augments Lipopolysaccharide Response through Association with FcR  in Mast Cells

(2009) K. Izawa et al.   JOURNAL OF IMMUNOLOGY

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype

(2009) George P Christophi et al.   LABORATORY INVESTIGATION

PIM2 Induced COX-2 and MMP-9 Expression in Macrophages Requires PI3K and Notch1 Signaling

(2009) Kushagra Bansal et al.   PLoS One

Central Neuroinvasion and Demyelination by Inflammatory Macrophages After Peripheral Virus Infection is Controlled by SHP-1

(2009) George P. Christophi et al.   VIRAL IMMUNOLOGY

Regulation of Immune Responses by the Activating and Inhibitory Myeloid-Associate Immunoglobuline-Like Receptors (MAIR) (CD300)

(2009) Akira Shibuya et al.   Immune Network

Cancer related inflammation: The macrophage connection

(2008) Antonio Sica et al.   CANCER LETTERS

Modulation of Macrophage Infiltration and Inflammatory Activity by the Phosphatase SHP-1 in Virus-Induced Demyelinating Disease

(2008) G. P. Christophi et al.   JOURNAL OF VIROLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE