Editorial Material
Medicine, General & Internal
Katarzyna Romejko, Adam Rytel, Tomasz Rozmyslowicz, Stanislaw Niemczyk
Summary: Renal cell carcinoma (RCC) is a common genitourinary cancer, with clear cell renal cell carcinoma (ccRCC) being the most common histologic type. The incidence of ccRCC diagnosis has rapidly increased due to the development of imaging methods. However, a significant proportion of patients are already at metastatic stage at the time of diagnosis, with metastases commonly found in the lungs, bones, and liver. Metastasis of ccRCC to the heart is rare, and we present a rare case of ccRCC with heart tissue metastases visualized in transthoracic echocardiography.
Article
Chemistry, Multidisciplinary
Xiao-lian Liu, Gui-ming Zhang, Si-si Huang, Wen-hui Shi, Lin-xuan Ye, Zhong-lu Ren, Jia-jie Zhang, Shu-wen Liu, Le Yu, Yi-lei Li
Summary: PTEN loss correlates with hypersensitivity to rapalogs in ccRCC cells and could be a marker for rapalog therapy selection in ccRCC patients.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Plant Sciences
Tao Wang, Zhiyuan Chen, Hui Chen, Xi Yu, Lei Wang, Xiuheng Liu
Summary: The study aimed to investigate the mechanism by which brusatol regulates the growth of renal cancer cells through the PTEN/PI3K/AKT signaling pathway. The results showed that brusatol significantly inhibited the proliferation, migration, and invasion of A498, ACHN, and OSRC-2 renal cancer cell lines, and increased apoptosis rates.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Franz Sellner, Eva Comperat, Martin Klimpfinger
Summary: Isolated pancreatic metastases of renal cell carcinoma (IsPMRCC) is a rare manifestation of metastatic renal cell carcinoma, and it has unique clinical characteristics such as delayed metastasis, multiple metastases, favorable treatment outcomes, and insensitivity to risk factors associated with volume and growth rate in metastatic surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Carolin Sauter-Meyerhoff, Regina Bohnert, Pascale Mazzola, Viktoria Stuehler, Siarhei Kandabarau, Florian A. Buettner, Stefan Winter, Lisa Herrmann, Steffen Rausch, Joerg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Stephan Ossowski, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Summary: Metastatic renal cell carcinoma (RCC) has poor prognosis, and understanding the genetic landscape of distant metastases is crucial for personalized treatment strategies. The somatic mutational composition is significantly associated with cancer-specific survival, and recurrent metastases show higher mutational burden. Synchronous and/or recurrent metastases of individual patients share a high proportion of somatic events even after a time-period >2 yrs, highlighting the importance of somatic profiling for precision medicine in RCC.
Review
Oncology
Rony Maelle, Ratone Jean-Philippe, Walz Jochen, Pignot Geraldine, Caillol Fabrice, Pesenti Christian, Guerin Mathilde, Dermeche Slimane, Brunelle Serge, Salem Naji, Vicier Cecile, Rybikowski Stanislas, Maubon Thomas, Fakhfakh Sami, Tejeda Manuel, Giovannini Marc, Gravis Gwenaelle
Summary: This study conducted a retrospective analysis of mRCC patients between 2007 and 2019 at the Paoli-Calmettes Institute in Marseille, France, revealing the rarity but significance of digestive metastases from renal cell cancer. Most patients presented with gastrointestinal bleeding or anemia, and a combination of local and systemic treatments may improve survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Elshad Hasanov, Debra Nana Yeboa, Mathew D. Tucker, Todd A. Swanson, Thomas Hendrix Beckham, Brian Rini, Chibawanye I. Ene, Merve Hasanov, Sophie Derks, Marion Smits, Shaan Dudani, Daniel Y. C. Heng, Priscilla K. Brastianos, Axel Bex, Sahin Hanalioglu, Jeffrey S. Weinberg, Laure Hirsch, Maria I. Carlo, Ayal Aizer, Paul David Brown, Mehmet Asim Bilen, Eric Lin Chang, Jerry Jaboin, James Brugarolas, Toni K. Choueiri, Michael B. Atkins, Bradley A. McGregor, Lia M. Halasz, Toral R. Patel, Scott G. Soltys, David F. McDermott, James Bradley Elder, Mustafa K. Baskaya, James B. Yu, Robert Timmerman, Michelle Miran Kim, Melike Mut, James Markert, Kathryn Beal, Nizar M. Tannir, George Samandouras, Frederick F. Lang, Rachel Giles, Eric Jonasch
Summary: Brain metastases are a challenging manifestation of renal cell carcinoma, and the optimal treatment approach remains unclear. This study aimed to improve patient care by establishing algorithms for the management of brain metastases through literature review and expert surveys.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Oncology
Yan Sun, Liang Zhu, Pian Liu, Huan Zhang, Feng Guo, Xin Jin
Summary: In this study, researchers found that the upregulation of palmitoyl acyltransferase ZDHHC2 is associated with TKI resistance in ccRCC. ZDHHC2 mediates AGK S-palmitoylation to activate the PI3K-AKT-mTOR signaling pathway, which modulates sunitinib sensitivity. These findings suggest that targeting ZDHHC2 may improve the efficacy of sunitinib in treating ccRCC.
Article
Oncology
Li Hu, Xingbo Cheng, Zev Binder, Zhibin Han, Yibo Yin, Donald M. O'Rourke, Sida Wang, Yumeng Feng, Changjiang Weng, Anhua Wu, Zhiguo Lin
Summary: High expression of UBE2S is strongly associated with glioma malignancy and resistance to chemo-radiotherapy, making it a crucial biomarker of poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liliana Eleonora Semenescu, Ligia Gabriela Tataranu, Anica Dricu, Gheorghe Vasile Ciubotaru, Mugurel Petrinel Radoi, Silvia Mara Baez Rodriguez, Amira Kamel
Summary: Despite the era of targeted therapies, neurosurgery still plays an important role in the treatment of brain metastases from renal cell carcinoma (BM RCC). This study found that nephrectomy, systemic therapy, and a single brain metastasis were associated with improved survival rates. Additionally, higher levels of hemoglobin were correlated with an increased number of brain metastases.
Article
Oncology
Jianpo Zhai, Ning Liu, Hai Wang, Guanglin Huang, Libo Man
Summary: This study aimed to define the clinical characteristics and prognostic factors of RCC with spinal bone metastasis (sBM). The analysis found that MSKCC risk stratification, number of sBM, visceral metastasis, and en-block resection are significant prognostic factors for overall survival in RCC patients with spinal BM. For selected patients with solitary spinal BM and no visceral metastasis, en-block resection of spinal BM may potentially prolong survival and is the treatment of choice.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Ke Liang, Yichu Yuan, Bodong Lv, Zunjin Ke
Summary: A 52-year-old male patient was diagnosed with primary renal SCC, which was difficult to diagnose. Surgical treatment was performed and the patient had a good short-term prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Oncology
Elizabeth P. Henske, Liang Cheng, A. Ari Hakimi, Toni K. Choueiri, David A. Braun
Summary: Chromophobe renal cell carcinoma (ChRCC) is the second most common variant of non-clear cell renal cell carcinoma. ChRCC differs from clear cell RCC (ccRCC) in terms of genetics, genomics, metabolism, cell of origin, and response to targeted and immune therapies. The pathogenesis of ChRCC is not well understood, but current evidence suggests two potential mechanisms: mTORC1 hyperactivation through PTEN pathway mutations and mitochondrial dysfunction leading to oxidative stress.
Article
Oncology
Yidan Lou, Kaibo Guo, Song Zheng
Summary: This report describes a rare case of renal cell carcinoma metastasis to the pancreas, with isolated pancreatic metastasis being even rarer. The patient responded well to surgery and systemic therapy, and showed no recurrence after 2 years. In conclusion, isolated pancreatic metastasis of renal cell carcinoma is a distinct subtype with unique clinical characteristics, which may be explained by underlying molecular mechanisms. Surgery and systemic therapy offer survival benefits to patients with isolated pancreatic metastasis, although recurrence should be closely monitored.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Giuseppe Malleo, Roberto Salvia, Laura Maggino, Giovanni Marchegiani, Michael D'Angelica, Ronald DeMatteo, Peter Kingham, Alessandra Pulvirenti, Elisabetta Sereni, William R. Jarnagin, Claudio Bassi, Peter J. Allen, Giovanni Butturini
Summary: This study focused on the long-term outcomes of pancreatectomy for pancreatic metastases from renal cell carcinoma and found that in selected patients with mostly isolated metachronous metastases, resection was associated with a high possibility of long-term disease control. The study observed a 10-year cumulative incidence of new RCC recurrence and disease-specific death, with certain risk factors such as synchronous metastases and extended pancreatectomy influencing recurrence and death rates. In patients with repeated recurrence, the cumulative incidence of RCC-related death was also noted.
ANNALS OF SURGICAL ONCOLOGY
(2021)
