Journal
CANCER INVESTIGATION
Volume 28, Issue 1, Pages 103-110Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900903095680
Keywords
Dickkopf (Dkk)-1; Loss of heterozygosity; Head and neck squamous cell carcinoma; Metastasis; Biomarker
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Funding
- Ministry of Education, Culture, Sports, Science and Technology [19592109, 20791337]
- Japan Science and Technology Agency
- Astrazeneca Research Grant
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Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50%) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.
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