Journal
CANCER INVESTIGATION
Volume 28, Issue 3, Pages 230-241Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900903095698
Keywords
Wnt2/beta-catenin; Sodium nitroprusside; siRNA; Apoptosis; Esophageal squamous cell carcinoma
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Funding
- Institutions of Higher Learning, Ministry of Education of P.R. China [20050459007]
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Inhibition of Wnt/beta-catenin pathway is an attractive method for therapy of various tumors including breast, colorectal, and cervical cancer, etc. However, little is known about the role of Wnt2/beta-catenin pathway in esophageal squamous cell carcinoma (ESCC). Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy.
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