Article
Sport Sciences
Morgan J. Farley, David B. Bartlett, Tina L. Skinner, Mia A. Schaumberg, David G. Jenkins
Summary: Exercise has been proven to improve physical and psychosocial well-being for cancer patients. The relationship between exercise and cancer outcomes is believed to be due to the release of anti-inflammatory myokines from skeletal muscle tissue. One important myokine, Interleukin-15 (IL-15), plays a key role in the immune response to cancer by supporting the growth and maturation of T cells and NK cells. Research is needed to better understand how exercise-induced increases in IL-15 can benefit cancer patients.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Oncology
Jayanth S. Shankara Narayanan, Tomoko Hayashi, Suna Erdem, Sara McArdle, Herve Tiriac, Partha Ray, Minya Pu, Zbigniew Mikulski, Aaron Miller, Karen Messer, Dennis Carson, Stephen Schoenberger, Rebekah R. White
Summary: The combination of IRE and CD40Ab treatment can significantly improve the prognosis of pancreatic cancer, prolong patient survival, activate dendritic cells, identify and inhibit the progression of metastatic disease.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Yu Igata, Motohiro Kojima, Toshiyuki Suzuki, Genichiro Ishii, Ryo Morisue, Toshihiro Suzuki, Masashi Kudo, Motokazu Sugimoto, Shin Kobayashi, John D. Martin, Triantafyllos Stylianopoulos, Horacio Cabral, Mitsunobu R. Kano, Masaru Konishi, Naoto Gotohda
Summary: This study analyzed the physical and pathological features of pancreatic ductal adenocarcinoma (PDAC) and found that tumor stiffness was associated with specific pathological features. The stiffness of PDAC was correlated with the areas of Azan-Mallory staining, alpha-smooth muscle actin, and collagen I. Additionally, the density of immune cells was associated with tumor stiffness, but this relationship changed after preoperative therapy.
Article
Oncology
Daniel R. Principe, Murray Korc, Suneel D. Kamath, Hidayatullah G. Munshi, Ajay Rana
Summary: Immunotherapy has revolutionized cancer treatment in the past decade, but has faced exceptional challenges in pancreatic ductal adenocarcinoma. Despite many different immunotherapies being explored in clinical trials, few have shown significant therapeutic efficacy.
Article
Oncology
Tomotaka Ugai, Li Liu, Fred K. Tabung, Tsuyoshi Hamada, Benjamin W. Langworthy, Naohiko Akimoto, Koichiro Haruki, Yasutoshi Takashima, Kazuo Okadome, Hidetaka Kawamura, Melissa Zhao, Seyed Mostafa Mousavi Kahaki, Jonathan N. Glickman, Jochen K. Lennerz, Xuehong Zhang, Andrew T. Chan, Charles S. Fuchs, Mingyang Song, Molin Wang, Kun-Hsing Yu, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Kana Wu, Shuji Ogino, Edward L. Giovannucci
Summary: This study found that pro-inflammatory diets after colorectal cancer diagnosis were associated with increased mortality, particularly in patients with low immune responses.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Chae Yoon Lim, Jae Hyuck Chang, Won Sun Lee, Jeana Kim, Il Young Park
Summary: CD40 agonists have the potential to alter macrophage phenotype polarization, inhibit pancreatic cancer growth, and serve as a promising therapeutic approach.
Article
Cell Biology
Jinyu Wang, Michela Manni, Anne Baerenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Michal Stanczak, Alfred Zippelius, David Koenig, Natalia Rodrigues Manutano, Heinz Laeubli
Summary: Interactions between sialylated glycans and Siglec receptors have been identified as a potential new immune checkpoint to improve anticancer immunity. In this study, it was found that cancer-associated dendritic cells (DCs) have a high expression of inhibitory Siglecs, which can impair their maturation states. Furthermore, removing these inhibitory Siglecs from DCs enhances their capability to prime antigen-specific T cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Huiru Zhang, Longyun Ye, Xianjun Yu, Kaizhou Jin, Weiding Wu
Summary: Pancreatic cancer has a unique inhibitory tumor microenvironment, which hinders the effectiveness of treatments. Neoadjuvant therapy has potential advantages in improving surgical resection rate, eliminating micrometastases, and selecting appropriate surgical candidates, while also inducing strong immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Asif Halimi, Giorgio Gabarrini, Michal Jacek Sobkowiak, Zeeshan Ateeb, Haleh Davanian, Rogier Aaron Gaiser, Urban Arnelo, Roberto Valente, Alicia Y. W. Wong, Carlos Fernandez Moro, Marco Del Chiaro, Volkan Ozenci, Margaret Sallberg Chen
Summary: The study reveals a potential link between pancreatic cystic lesions and cancer, with cultivated bacteria demonstrating pathogenic properties such as intracellular survival capability, cell death induction, and causing DNA double-strand breaks in surviving cells.
Article
Surgery
Marina N. Nikiforova, Abigail I. Wald, Daniel M. Spagnolo, Melissa A. Melan, Maria Grupillo, Yi-Tak Lai, Randall E. Brand, Anne Marie O'Broin-Lennon, Kevin Mcgrath, Walter G. Park, Patrick R. Pfau, Patricio M. Polanco, Nisa Kubiliun, John Dewitt, Jeffrey J. Easler, Aamir Dam, Shaffer R. Mok, Michael B. Wallace, Vivek Kumbhari, Brian A. Boone, Wallis Marsh, Shyam Thakkar, Kimberly J. Fairley, Elham Afghani, Yasser Bhat, Sanjay Ramrakhiani, John Nasr, Wasseem Skef, Nikhil R. Thiruvengadam, Asif Khalid, Kenneth Fasanella, Jennifer Chennat, Rohit Das, Harkirat Singh, Savreet Sarkaria, Adam Slivka, Charles Gabbert, Tarek Sawas, Thomas Tielleman, Hendrikus Dutch Vanderveldt, Anna Tavakkoli, Lynette M. Smith, Katelyn Smith, Phoenix D. Bell, Ralph H. Hruban, Alessandro Paniccia, Amer Zureikat, Kenneth K. Lee, Melanie Ongchin, Herbert Zeh, Rebecca Minter, Jin He, Yuri E. Nikiforov, Aatur D. Singhi
Summary: We developed a combined DNA/RNA sequencing platform to improve the evaluation of pancreatic cysts. The newly created genomic classifier system accurately predicted cystic precursor neoplasms and advanced neoplasia, while also increasing the sensitivity of current pancreatic cyst guidelines.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Hee Yoon, Jae Seok Bae, Sunkyung Jeon, Won Chang, Sang Min Lee, Jin Young Park, Jeong Sub Lee, Eun Sun Lee, In Rae Cho, Sang-Hyub Lee, Jeong Min Lee
Summary: The study aimed to establish an accelerated MRI protocol for pancreatic cancer surveillance and evaluate its performance in lesion characterization. 30 participants underwent the protocol, and the results showed that accelerated MRI had similar diagnostic performance to CECT and higher diagnostic confidence.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Oncology
Seonhyang Jeong, Seul-Gi Lee, Hyunji Kim, Gibbeum Lee, Sunmi Park, In-Kyu Kim, Jandee Lee, Young-Suk Jo
Summary: FAL1 upregulation has been reported in various types of human cancer, with a simultaneous upregulation adjacent to chromosome 1q21.3 identified using The Cancer Genome Atlas (TCGA) database. c-JUN and JUND were selected as master transcription factors for FAL1, and the molecular biological features represented RAS-driven papillary thyroid cancer (PTC). This simultaneous upregulation could potentially serve as a diagnostic and therapeutic target for RAS-driven PTC.
Article
Oncology
A. L. Schmidt, C. Labaki, C-Y Hsu, Z. Bakouny, N. Balanchivadze, S. A. Berg, S. Blau, A. Daher, T. El Zarif, C. R. Friese, E. A. Griffiths, J. E. Hawley, B. Hayes-Lattin, V Karivedu, T. Latif, B. H. Mavromatis, R. R. McKay, G. Nagaraj, R. H. Nguyen, O. A. Panagiotou, A. J. Portuguese, M. Puc, M. Santos Dutra, B. A. Schroeder, A. Thakkar, E. M. Wulff-Burchfield, S. Mishra, D. Farmakiotis, Yu Shyr, J. L. Warner, T. K. Choueiri
Summary: This study analyzes the clinical features of cancer patients who develop symptomatic COVID-19 after vaccination. It finds that these patients often have comorbidities and can experience severe and even lethal infections. Hematologic malignancy patients are over-represented among the vaccinated cancer patients who develop symptomatic COVID-19. Therefore, while vaccination remains crucial in protecting vulnerable populations, including cancer patients, those who develop breakthrough infections despite full vaccination still face the risk of severe outcomes.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Hyun Jeong Jeon, Hye Jeong Jeong, Soo Yeun Lim, So Jeong Yoon, Hongbeom Kim, In Woong Han, Jin Seok Heo, Sang Hyun Shin
Summary: This study aimed to investigate the clinical course of patients with advanced pancreatic cancer who underwent resection following FOLIFIRNOX treatment. The results showed that patients with complete pathologic response (cPR) and nearly complete pathologic response (ncPR) had longer overall survival and disease-free survival. Additionally, adjuvant chemotherapy following neoadjuvant treatment might be beneficial for patient outcomes.
Article
Oncology
Eline S. Zwart, Thomas van Ee, Alsya J. Affandi, Lenka N. C. Boyd, Ernesto Rodriguez, Joke M. M. den Haan, Arantza Farina, Nicole C. T. van Grieken, Laura L. Meijer, Yvette van Kooyk, Reina E. Mebius, Geert Kazemier
Summary: This study examined the immune microenvironment composition in different sites of resected pancreas specimens from pancreatic ductal adenocarcinoma (PDAC) patients. The results showed a decreased ratio of lymphoid and myeloid cells, as well as M1 and M2 macrophages, in the tumor tissue compared to non-tumorous tissue. Additionally, an increase in CD169+ macrophages was observed in patients undergoing neoadjuvant therapy, and the PDAC area had more immune-suppressive cells and a lower ratio of CD8 to M2 macrophages compared to adjacent non-tumorous tissue. Furthermore, there were more immune-suppressive cells in the central tumor area compared to the invasive front.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Haruka Miyata, Yoshihiko Hirohashi, Shuhei Yamada, Junko Yanagawa, Aiko Murai, Shinichi Hashimoto, Serina Tokita, Kanta Hori, Takashige Abe, Terufumi Kubo, Tomohide Tsukahara, Takayuki Kanaseki, Nobuo Shinohara, Toshihiko Torigoe
Summary: Recent studies have shown that treatment-resistant cancer stem-like cells can be targeted by cytotoxic T lymphocytes, with a specific antigenic peptide (LMYDAVHVV) derived from GRIK2 being identified as a potential novel target for bladder CSC/CIC immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Masahiro Matsuki, Yoshihiko Hirohashi, Munehide Nakatsugawa, Aiko Murai, Terufumi Kubo, Shinichi Hashimoto, Serina Tokita, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Toshiaki Tanaka, Hiroshi Kitamura, Naoya Masumori, Toshihiko Torigoe
Summary: ICIs are used in cancer immunotherapy to block certain pathways, but low response rates and tumor heterogeneity can lead to resistance. This study found that the specificity of TILs in RCC may be related to gene mutations and reactivity, suggesting heterogenous tumors may have diverse gene mutations and responses to TILs.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Takahito Wakamiya, Yoshihiko Hirohashi, Aiko Murai, Junko Yanagawa, Yuka Mizue, Terufumi Kubo, Shinichi Hashimoto, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Yasuo Kohjimoto, Isao Hara, Toshihiko Torigoe
Summary: The ALDH1-high prostate cancer stem-like cells (CSCs) exhibit heterogeneity in tumorigenicity and resistance to radiation and chemotherapy, along with lower levels of phosphorylated AKT. Insulin can activate AKT signaling in these cells, leading to resistance to radiation and chemotherapy. These findings suggest a potential mechanism for treatment resistance in prostate cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masanori Someya, Yuki Fukushima, Tomokazu Hasegawa, Takaaki Tsuchiya, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoh Kozuka, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-Ichi Sakata
Summary: This review discusses the application of radiotherapy for human papillomavirus (HPV)-related cancer and the mechanism of tumor immunity. It also explores how chemoradiotherapy can improve the efficacy of tumor immunity. Additionally, it highlights the usefulness of tumor immunity-related proteins as predictive markers of radiotherapy response, and provides an overview of ongoing clinical trials of combinations of immune checkpoint inhibitors and radiotherapy.
JAPANESE JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
Yuta Nambu, Tasuku Mariya, Shota Shinkai, Mina Umemoto, Hiroko Asanuma, Ikuma Sato, Yoshihiko Hirohashi, Toshihiko Torigoe, Yuichi Fujino, Tsuyoshi Saito
Summary: This study developed a fast and accurate system for detecting and classifying atypical cell clusters using two different deep learning algorithms. The combination of YOLOv4 and ResNeSt algorithms allowed the system to effectively handle overlapping and crowded cell images, achieving high accuracy in cell detection and classification.
Article
Oncology
Takashi Sasaya, Terufumi Kubo, Kenji Murata, Yuka Mizue, Kenta Sasaki, Junko Yanagawa, Makoto Imagawa, Hirotaka Kato, Tomohide Tsukahara, Takayuki Kanaseki, Yasuaki Tamura, Akihiro Miyazaki, Yoshihiko Hirohashi, Toshihiko Torigoe
Summary: This study investigates the effects of cisplatin on the immunotherapy response of oral squamous cell carcinoma (OSCC) and finds that cisplatin increases the surface levels of PD-L1 on OSCC cells but does not alter gene and total protein expression levels. Moreover, cisplatin-induced PD-L1 attenuates the cytotoxic T lymphocyte reaction to OSCC.
Article
Biochemistry & Molecular Biology
Hanae Ichioka, Yoshihiko Hirohashi, Tatsuya Sato, Masato Furuhashi, Megumi Watanabe, Yosuke Ida, Fumihito Hikage, Toshihiko Torigoe, Hiroshi Ohguro
Summary: To investigate the molecular mechanisms responsible for aberrant expression of recoverin (Rec) in cancer cells, Rec-negative lung adenocarcinoma cells (A549) were transfected with a human recoverin cDNA plasmid (A549 Rec) or an empty plasmid (A549 MOCK). The A549 Rec cells showed increased sensitivity to anti-tumor agents, altered cellular metabolism, and formation of larger and stiffer 3D spheroids compared to A549 MOCK. RNA sequencing analysis suggested that aberrantly expressed Rec may be associated with G-protein-coupled receptor (GPCR)-mediated signaling and the cAMP response element binding protein (CREB) signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grutzmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Leonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Benedicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon Van Lent-van Vliet, Nikki Knijn, Ana-Maria Musing, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pages, Jerome Galon
Summary: This study found that the immune system status is a better predictor of prognosis in early-stage colon cancer patients than tumor cell-related parameters. The consensus Immunoscore accurately identifies early-stage colon cancer patients with different clinical outcomes, regardless of treatment bias.
Article
Oncology
Sho Miyamoto, Yoshihiko Hirohashi, Rena Morita, Akihiro Miyazaki, Kazuhiro Ogi, Takayuki Kanaseki, Kentaro Ide, Jumpei Shirakawa, Tomohide Tsukahara, Aiko Murai, Takashi Sasaya, Kazushige Koike, Shinichiro Kina, Toshihiro Kawano, Takahiro Goto, Edward Hosea Ntege, Yusuke Shimizu, Toshihiko Torigoe
Summary: Despite advances in cancer therapies, the mortality rate of oral cancer has not improved in the past three decades. Oral cancers contain a subpopulation of cancer stem cells (CSCs) that contribute to cancer infiltration, recurrence, metastasis, and drug resistance. Cytotoxic CD8+ T lymphocytes (CTLs) play a crucial role in targeting CSCs and regulating cancer progression. This study investigates the potential of olfactory receptor family 7 subfamily C member 1 (OR7C1) as a target for CSC-targeted immunotherapy in oral cancer and finds that OR7C1 is expressed only in oral CSCs and is effectively recognized by CTLs.
Article
Oncology
Shohei Sekiguchi, Akira Yorozu, Fumika Okazaki, Takeshi Niinuma, Akira Takasawa, Eiichiro Yamamoto, Hiroshi Kitajima, Toshiyuki Kubo, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Atsushi Kondo, Makoto Kurose, Kazufumi Obata, Akito Kakiuchi, Masahiro Kai, Yoshihiko Hirohashi, Toshihiko Torigoe, Takashi Kojima, Makoto Osanai, Kenichi Takano, Akihiro Miyazaki, Hiromu Suzuki
Summary: This study demonstrates that aortic carboxypeptidase-like protein (ACLP) is highly expressed in cancer-associated fibroblasts (CAFs) in oral squamous cell carcinoma (OSCC) and is activated by cancer cell-induced TGF-β1 signaling pathway. ACLP derived from CAFs enhances migration and infiltration of cancer cells. Furthermore, ACLP is co-expressed with collagen and negatively correlates with tumor infiltration of CD8+ T lymphocytes, suggesting a potential therapeutic target for stromal-targeted therapy and cancer immunotherapy.
Article
Oncology
Joseph Willis, Robert A. Anders, Toshihiko Torigoe, Yoshihiko Hirohashi, Carlo Bifulco, Inti Zlobec, Bernhard Mlecnik, Sandra Demaria, Won-Tak Choi, Pavel Dundr, Fabiana Tatangelo, Annabella Di Mauro, Pamela Baldin, Gabriela Bindea, Florence Marliot, Nacilla Haicheur, Tessa Fredriksen, Amos Kirilovsky, Benedicte Buttard, Angela Vasaturo, Lucie Lafontaine, Pauline Maby, Carine El Sissy, Assia Hijazi, Amine Majdi, Christine Lagorce, Anne Berger, Marc van den Eynde, Franck Pages, Alessandro Lugli, Jerome Galon
Summary: This study compares the performance of a standardized Immunoscore (IS) digital pathology assay to visual examination by expert pathologists. The results show that the IS assay outperforms the pathologists' evaluation in the clinical setting, demonstrating the potential of IS as an immune pathology tool. These findings can contribute to better diagnosis and prognosis of cancer patients and highlight the importance of digital pathology in cancer management.
Article
Medicine, Research & Experimental
Shin Kobayashi, Serina Tokita, Keigo Moniwa, Katsuyuki Kitahara, Hiromichi Iuchi, Kazuhiko Matsuo, Hidehiro Kakizaki, Takayuki Kanaseki, Toshihiko Torigoe
Summary: CD8+ T cells can recognize and eliminate tumor cells by targeting tumor antigens displayed by HLA class I molecules. In this study, the presence of immunogenic hERV antigens in renal cell carcinoma tissues was identified, and their potential clinical applications in patients with RCC were suggested.
Review
Immunology
Terufumi Kubo, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Rena Morita, Toshihiko Torigoe
Summary: Despite the success of cancer immunotherapy using immune checkpoint inhibitors, the nonspecific release of immunosuppressive mechanisms can lead to immune-related adverse events (irAEs) that significantly impact patients' quality of life. Proper management of irAEs is crucial for the advancement of reliable cancer immunotherapies. IrAEs resemble autoimmune diseases but often have distinct features, and while the detailed pathogenesis remains unclear, numerous studies are providing insights into this phenomenon.
IMMUNOLOGICAL MEDICINE
(2022)