Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1

Cancer statistics, 2014

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Stable CD8+ T Cell Memory during Persistent Trypanosoma cruzi Infection

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Recruitment and Endo-Lysosomal Activation of TLR9 in Dendritic Cells Infected with Trypanosoma cruzi

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Price of Tumor Control: An Analysis of Rare Side Effects of Anti-CTLA-4 Therapy in Metastatic Melanoma from the Ipilimumab Network

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Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

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Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

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Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients

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Cancer immunotherapy shows promise in multiple tumor types

(2012) Monica Heger   NATURE MEDICINE

Tumor Infiltrating CD8+ and Foxp3+ Lymphocytes Correlate to Clinical Outcome and Human Papillomavirus (HPV) Status in Tonsillar Cancer

(2012) Anders Näsman et al.   PLoS One

Trypanosoma cruzi Adjuvants Potentiate T Cell-Mediated Immunity Induced by a NY-ESO-1 Based Antitumor Vaccine

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Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice

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Immunoediting and persistence of antigen-specific immunity in patients who have previously been vaccinated with NY-ESO-1 protein formulated in ISCOMATRIX™

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Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

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Requirement of UNC93B1 Reveals a Critical Role for TLR7 in Host Resistance to Primary Infection with Trypanosoma cruzi

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Improvement of different vaccine delivery systems for cancer therapy

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Multiple Cancer/Testis Antigens Are Preferentially Expressed in Hormone-Receptor Negative and High-Grade Breast Cancers

(2011) Yao-Tseng Chen et al.   PLoS One

Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

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Trypanosoma cruzi as an effective cancer antigen delivery vector

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Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

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Salmonella as Live Trojan Horse for Vaccine Development and Cancer Gene Therapy

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

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CD8+ T cells in Trypanosoma cruzi infection

(2009) Angel M Padilla et al.   CURRENT OPINION IN IMMUNOLOGY

The role of IFN-γ Elispot assay in HIV vaccine research

(2009) Hendrik Streeck et al.   Nature Protocols

Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes

(2009) Troy Dillard et al.   Pituitary

Secondary Replicative Function of CD8+ T Cells That Had Developed an Effector Phenotype

(2009) O. Bannard et al.   SCIENCE