Therapeutic effects of metformin in breast cancer: involvement of the immune system?

Metformin and Incident Breast Cancer among Diabetic Women: A Population-Based Case-Control Study in Denmark

(2011) J. L. F. Bosco et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

(2011) Bolin Liu et al.   CELL CYCLE

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

(2011) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase

(2010) Kristy A. Brown et al.   BREAST CANCER RESEARCH AND TREATMENT

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

(2010) Pamela J. Goodwin et al.   BREAST CANCER RESEARCH AND TREATMENT

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

(2010) Alejandro Vazquez-Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

(2010) R. Novosyadlyy et al.   CANCER RESEARCH

Molecular biology of breast cancer stem cells: Potential clinical applications

(2010) Nam P. Nguyen et al.   CANCER TREATMENT REVIEWS

Metformin: A Therapeutic Opportunity in Breast Cancer

(2010) A. M. Gonzalez-Angulo et al.   CLINICAL CANCER RESEARCH

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

Diabetes therapy and cancer risk: causal effects and other plausible explanations

(2010) S. Hernández-Díaz et al.   DIABETOLOGIA

Metformin: Taking away the candy for cancer?

(2010) Mathilde Jalving et al.   EUROPEAN JOURNAL OF CANCER

Clinically Defined Type 2 Diabetes Mellitus and Prognosis in Early-Stage Breast Cancer

(2010) Kirsten Erickson et al.   JOURNAL OF CLINICAL ONCOLOGY

Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

(2010) Kimberly S. Peairs et al.   JOURNAL OF CLINICAL ONCOLOGY

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

(2009) Kathryn N. Phoenix et al.   BREAST CANCER RESEARCH AND TREATMENT

Is it Time to Test Metformin in Breast Cancer Clinical Trials?

(2009) M. Cazzaniga et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes-Mediated Mammary Tumor Progression

(2009) Y. Fierz et al.   DIABETES

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

News and Views

(2009) Iskandar Idris   DIABETES OBESITY & METABOLISM

Combined randomised controlled trial experience of malignancies in studies using insulin glargine

(2009) P. D. Home et al.   DIABETOLOGIA

Insulin glargine use and short-term incidence of malignancies—a population-based follow-up study in Sweden

(2009) J. M. Jonasson et al.   DIABETOLOGIA

Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group

(2009) H. M. Colhoun et al.   DIABETOLOGIA

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

(2009) C. J. Currie et al.   DIABETOLOGIA

Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study

(2009) L. G. Hemkens et al.   DIABETOLOGIA

If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials

(2009) Alejandro Vazquez-Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin in Breast Cancer: Time for Action

(2009) Pamela J. Goodwin et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Antidiabetic agents and cardiovascular risk in type 2 diabetes

(2009) Stuart W. Zarich   Nature Reviews Endocrinology

Sulphonylureas and cancer: a case–control study

(2008) Matteo Monami et al.   ACTA DIABETOLOGICA

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model

(2008) Kathryn N. Phoenix et al.   BREAST CANCER RESEARCH AND TREATMENT

Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes

(2008) M. E. Solano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY