Review
Chemistry, Inorganic & Nuclear
Dandan Wang, Wenxing Gu, Weiliang Chen, Jin Zhou, Le Yu, Byung Kook Kim, Xuenong Zhang, Jong Seung Kim
Summary: Nanovaccines based on nanomaterials have emerged as an advanced technology for enhancing anti-tumor immunotherapy. They stimulate antigen presenting cells to release signals and activate immune-killing T cells, improving the efficacy of immunotherapy. The positive regulation of nanovaccines enhances antigen presentation and recruits more immune-killing T cells.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Oncology
Robert J. Klein, Emily Vertosick, Dan Sjoberg, David Ulmert, Ann-Charlotte Ronn, Christel Haggstrom, Elin Thysell, Goran Hallmans, Anders Dahlin, Par Stattin, Olle Melander, Andrew Vickers, Hans Lilja
Summary: Polygenic risk scores (PRS) for prostate cancer incidence were evaluated and compared to PSA and a commercialized model in predicting lethal prostate cancer. The study found that PRS was associated with incident prostate cancer, but was not a stronger predictor of lethal disease compared to PSA. The combination of PRS and PSA did not contribute additional risk stratification for lethal prostate cancer.
NPJ PRECISION ONCOLOGY
(2022)
Editorial Material
Immunology
Hu Chen, Hongwei Cheng, Xiaoliu Liang, Shundong Cai, Gang Liu
Summary: Although immunotherapy has brought new possibilities for cancer treatment, insufficient immune response limits its effectiveness. The ASPIRE nanovaccine derived from dendritic cells offers a simplified and personalized approach to immunotherapy, potentially revolutionizing cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jinyu Wang, Michela Manni, Anne Baerenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Michal Stanczak, Alfred Zippelius, David Koenig, Natalia Rodrigues Manutano, Heinz Laeubli
Summary: Interactions between sialylated glycans and Siglec receptors have been identified as a potential new immune checkpoint to improve anticancer immunity. In this study, it was found that cancer-associated dendritic cells (DCs) have a high expression of inhibitory Siglecs, which can impair their maturation states. Furthermore, removing these inhibitory Siglecs from DCs enhances their capability to prime antigen-specific T cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Enrica Marmonti, Jacqueline Oliva-Ramirez, Cara Haymaker
Summary: Dendritic cells (DCs) are crucial in immunology, yet targeting them remains challenging. Understanding and utilizing dendritic cells can lead to new therapeutic strategies in cancer treatment.
Article
Chemistry, Physical
Shaoli Liu, Qiao Jiang, Xiao Zhao, Ruifang Zhao, Yuanning Wang, Yiming Wang, Jianbing Liu, Yingxu Shang, Shuai Zhao, Tiantian Wu, Yinlong Zhang, Guangjun Nie, Baoquan Ding
Summary: A DNA nanodevice vaccine has been developed to stimulate a tumor-specific cytotoxic T lymphocyte response, leading to inhibition of tumor growth and prevention of metastasis. The vaccine utilizes molecular adjuvants and antigen peptides within a tubular DNA nanostructure to trigger T-cell activation and cancer cytotoxicity, showing promising results in mouse cancer models. The vaccination generates long-term T-cell responses which effectively protect against tumor rechallenge.
Review
Neurosciences
Vito Di Maio
Summary: The glutamatergic synapse, as the most abundant synaptic type, plays a crucial role in information processing in the brain. Despite the basic simplicity of synaptic transmission, there is a large variation in response to neurotransmitter release, indicating complex control mechanisms. These mechanisms involve the management and coordination of information transfer among neurons, highlighting the intricate and not fully understood functionality of synaptic control.
COGNITIVE NEURODYNAMICS
(2021)
Article
Multidisciplinary Sciences
Nima Sayyadi, Irene Justiniano, Yan Wang, Xianlin Zheng, Wei Zhang, Lianmei Jiang, Dmitry M. Polikarpov, Robert D. Willows, David Gillatt, Douglas Campbell, Bradley J. Walsh, Jingli Yuan, Yiqing Lu, Nicolle H. Packer, Yuling Wang, James A. Piper
Summary: Two molecular cytology approaches, TGiA and RiA, have been developed to detect prostate cancer cells. TGiA-OSAM showed single-cell PCa detection sensitivity, while RiA had a lower limit of detection. Both assays detected low abundance PCa cells in patient urine and showed correlation with clinical data.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Jie Yang, Xiuhua Pan, Jun Zhang, Siyu Ma, Jianeng Zhou, Zengguang Jia, Yawen Wei, Zengyi Liu, Ning Yang, Qi Shen
Summary: Dendritic cells (DCs) play a crucial role in the immune response against tumors, but their immunosuppressive cholesterol metabolism in tumors leads to dysfunctional DCs and limited antigen presentation. In this study, a metabolism nano-intervenor was developed to interfere with DCs' cholesterol metabolism and enhance antigen presentation. The system, consisting of DC-targeting nanoparticles and a hydrogel with sustained release, achieved precise and long-term immunometabolism intervention. Reprogramming DCs' metabolism significantly improved the efficacy of DC-mediated immunotherapy, especially in combination with immune-checkpoint inhibition induced by metformin hydrochloride (MET).
Article
Chemistry, Multidisciplinary
Ping Xiao, Jue Wang, Zitong Zhao, Xiaochen Liu, Xiangshi Sun, Dangge Wang, Yaping Li
Summary: Metabolic labeling of DCs is utilized to design nanoscale aAPCs that exhibit enhanced distribution in lymph nodes, activation of T cells and resident APCs, significant inhibition of tumor inoculation and growth, and improved efficacy when combined with PD1 therapy.
Article
Oncology
Fikri Abali, Narges Baghi, Lisanne Mout, Joska J. Broekmaat, Arjan G. J. Tibbe, Leon W. M. M. Terstappen
Summary: The study highlights the importance of measuring protein secretion from individual cancer cells and how it can be influenced by different drugs. It shows that this method has the potential to accelerate drug development, enhance understanding of therapy resistance, and improve personalized cancer treatment.
Article
Medicine, General & Internal
Paul F. Pinsky, Howard Parnes
Summary: Screening for prostate cancer should take into consideration the risks and benefits. PSA screening can reduce prostate cancer deaths, but the reduction is small. Follow-up tests such as biopsy and MRI may be needed for individuals with elevated PSA levels. Patients with low-risk or favorable intermediate-risk prostate cancer may choose active surveillance over immediate curative treatment. Surgery and radiation therapy have good outcomes but can lead to complications.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biology
Igor Tsaur, Anita Thomas, Eva Juengel, Sebastian Maxeiner, Timothy Grein, Quynh Chi Le, Veronika Muschta, Jochen Rutz, Felix K. H. Chun, Roman A. Blaheta
Summary: The study showed that sE-cadherin influences the behavior of prostate cancer cells, enhancing their invasiveness and potentially serving as a new therapeutic target for advanced PCa.
Review
Immunology
Ichwaku Rastogi, Donghwan Jeon, Jena E. E. Moseman, Anusha Muralidhar, Hemanth K. Potluri, Douglas G. G. McNeel
Summary: This review discusses the role and function of B cells in the humoral immune system, as well as their ability to act as antigen presenting cells. B cells have been shown to activate antigen-specific T cells and have regulatory and cytotoxic effects. The importance of B cells within the tumor microenvironment is increasingly recognized, and B cells are being evaluated as cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Michael R. Shurin
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Oncology
Galina V. Shurin, Oleg Kruglov, Fei Ding, Yan Lin, Xingxing Hao, Anton A. Keskinov, Zhaoyang You, Anna E. Lokshin, William A. LaFramboise, Louis D. Falo, Michael R. Shurin, Yuri L. Bunimovich
Article
Biochemistry & Molecular Biology
Gulnur K. Zakiryanova, Elena Kustova, Nataliya T. Urazalieva, Emile T. Baimuchametov, Narymzhan N. Nakisbekov, Michael R. Shurin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Immunology
Michael R. Shurin, Galina V. Shurin, Samuel B. Zlotnikov, Yuri L. Bunimovich
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Deena M. Maurer, Juraj Adamik, Patricia M. Santos, Jian Shi, Michael R. Shurin, John M. Kirkwood, Walter J. Storkus, Lisa H. Butterfield
CANCER IMMUNOLOGY RESEARCH
(2020)
Review
Cell Biology
Michael R. Shurin, James H. Baraldi, Galina V. Shurin
Summary: Surgery can promote cancer metastasis through mechanisms such as the release of neuroendocrine hormones, immunosuppression, neovascularization, and tissue remodeling. The role of neuroimmune regulation in surgery-associated metastasis is not well understood, highlighting the need for further research in this area.
Article
Medical Laboratory Technology
Nathan Cook, Lingqing Xu, Shaymaa Hegazy, Bradley J. Wheeler, Adam R. Anderson, Nancy Critelli, Mary Yost, Anita K. McElroy, Michael R. Shurin, Sarah E. Wheeler
Summary: The study aimed to detect antibodies to different SARS-CoV-2 antigens, analyzing the performance of the BioRad SARS-CoV-2 IgG multiplex assay in terms of diagnostic accuracy, differentiation of vaccination and natural disease, and retrospective exposure determination. Results showed that the assay is comparable to existing methods, achieving 100% sensitivity when all markers are included, with practical implications for research and infection prevention strategies.
CLINICAL BIOCHEMISTRY
(2021)
Article
Microbiology
Sarah E. Wheeler, Galina Shurin, Mary Yost, Adam Anderson, Lisa Pinto, Alan Wells, Michael R. Shurin
Summary: Understanding the development and duration of virus-specific antibodies after COVID-19 vaccination is important for controlling the pandemic. Postvaccination antibody testing can help in monitoring individuals after vaccination and selecting those who may require additional doses or not need vaccination.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Lingqing Xu, Joshua Doyle, Dominique J. Barbeau, Valerie Le Sage, Alan Wells, W. Paul Duprex, Michael R. Shurin, Sarah E. Wheeler, Anita K. McElroy
Summary: This study found a 4.5-fold increase in SARS-CoV-2 seroprevalence from Fall 2020 to February 2021 in Allegheny County, Pennsylvania, due to increased incidence of both natural disease and vaccination. The neutralization titer was significantly correlated with RBD titer but not with N titer. In the February cohort, higher median income and white race were associated with serological findings consistent with vaccination.
Review
Oncology
James H. Baraldi, German Martyn, Galina Shurin, Michael R. Shurin
Summary: This comprehensive review summarizes the literature on tumor innervation, addressing the evidence, historical developments, and important mechanisms related to tumor development. It concludes that solid tumors are innervated and that nerves, neurons, and glia play a functional role in tumor development.
Review
Oncology
Nuray Erin, Galina V. Shurin, James H. Baraldi, Michael R. Shurin
Summary: Sensory nerve fibers and the vagus nerve play crucial roles in tumor growth and spread. Current findings are contradictory, likely due to the stage and aggressiveness of the tumor model. Sensory neurons and Schwann cells are important players in tumor development, growth, and progression.
Article
Oncology
Shuhui Cao, Yue Wang, Yan Zhou, Yao Zhang, Xuxinyi Ling, Lincheng Zhang, Jingwen Li, Yu Yang, Weimin Wang, Michael R. Shurin, Hua Zhong
Summary: This study demonstrates the role of tumor-associated Schwann cells in the progression of small-cell lung cancer by constructing a mRNA-miRNA-lncRNA network. The findings improve our understanding of the interaction between tumor cells and Schwann cells, and provide insights into cancer progression.
Article
Cell Biology
Galina Shurin, Kavita Vats, Oleg Kruglov, Yuri L. Bunimovich, Michael R. Shurin
Summary: Nerve-cancer crosstalk is controlled by Schwann cells, which can be stimulated by tumor cells to produce prostaglandin E. This inhibits the proliferation of activated T cells and leads to T cell exhaustion. Understanding this pathway is important for the development of cancer therapies.
Article
Chemistry, Multidisciplinary
Marina A. Dobrovolskaia, Michael R. Shurin, Valerian E. Kagan, Anna A. Shvedova
Editorial Material
Immunology
Michael R. Shurin
IMMUNOTARGETS AND THERAPY
(2018)