Journal
CANCER GENETICS AND CYTOGENETICS
Volume 203, Issue 2, Pages 278-283Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergencyto.2010.08.026
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Funding
- Deutsche Krebshilfe (German Cancer Aid) [107819]
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Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL), a fluorescence in situ hybridization (FISH)-negative cryptic PML-RARA rearrangement is even more rare, with only 12 such APL cases of FISH-negative cryptic PML-RARA rearrangements in the literature. Reported here is an additional clinical APL case with a FISH-negative cryptic PML-RARA rearrangement, confirmed by long-distance DNA polymerase chain reaction method. Discussion includes a relevant literature review of similar cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic rearrangements. (C) 2010 Elsevier Inc. All rights reserved.
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