Article
Oncology
Ekaterina S. Kuligina, Roman Meerovich, Kirill A. Zagorodnev, Maxim M. Kholmatov, Tatyana N. Sokolova, Tatiana A. Laidus, Aleksandr A. Romanko, Aleksandr S. Martianov, Maria O. Anisimova, Olga A. Zaitseva, Olga S. Yatsuk, Grigoriy A. Yanus, Evgeny N. Imyanito
Summary: This study found that the presence of ctDNA in plasma is characteristic for patients with progressing tumor disease. Consecutive plasma tests may occasionally provide discordant data, and repetition of analysis may be advised in certain cases to ensure the validity of negative ctDNA result.
Article
Genetics & Heredity
Igor E. Orlov, Tatiana A. Laidus, Anastasia Tumakova, Grigoriy A. Yanus, Aglaya G. Iyevleva, Anna P. Sokolenko, Ilya Bizin, Evgeny N. Imyanitov, Evgeny N. Suspitsin
Summary: Whole exome sequencing is a powerful tool for identifying population-specific genetic diseases. This study found recurrent pathogenic alleles in a small number of individual Russian exomes, with some being non-Russian-specific and others characteristic for subjects of Russian origin.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Oncology
Fedor Moiseyenko, Ekaterina S. Kuligina, Albina S. Zhabina, Sergey A. Belukhin, Tatiana A. Laidus, Aleksandr S. Martianov, Kirill A. Zagorodnev, Tatyana N. Sokolova, Svetlana A. Chuinyshena, Maxim M. Kholmatov, Elizaveta Artemieva, Ekaterina O. Stepanova, Tatiana N. Shuginova, Nikita M. Volkov, Grigoriy A. Yanus, Evgeny N. Imyanitov
Summary: The study found that changes in EGFR-mutated ctDNA concentration at 48 hours after the start of therapy can predict the duration of efficacy of TKIs.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Ekaterina Kuligina, Fedor Moiseyenko, Sergey Belukhin, Ekaterina Stepanova, Maria Zakharova, Vera Chernobrivtseva, Ikram Aliev, Tatiana Sharabura, Vladimir Moiseyenko, Svetlana Aleksakhina, Tatiana Laidus, Aleksandr Martianov, Maksim Kholmatov, Aldon Whitehead, Grigoriy Yanus, Evgeny Imyanitov
Summary: The mutation-based analysis of circulating tumor DNA is a promising diagnostic tool for clinical oncology. Preoperative tumor irradiation may transiently increase plasma ctDNA concentration due to induction of apoptosis. Local tumor irradiation may facilitate the detection of tumor-specific DNA in the bloodstream, supporting further evaluation of irradiation-assisted liquid biopsy.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Oncology
G. A. Yanus, E. L. Savonevich, A. P. Sokolenko, A. A. Romanko, V. Ni, E. Kh Bakaeva, O. A. Gorustovich, I. Bizin, E. N. Imyanitov
Summary: The study found that BRCA1/2 gene mutations in Belarusian population show a high level of founder allele effect. This is surprising as the population of Belarus did not experience geographic or cultural isolation throughout history.
Article
Biochemistry & Molecular Biology
Natalia V. Mitiushkina, Grigory A. Yanus, Ekatherina Sh. Kuligina, Tatiana A. Laidus, Alexandr A. Romanko, Maksim M. Kholmatov, Alexandr O. Ivantsov, Svetlana N. Aleksakhina, Evgeny N. Imyanitov
Summary: DNA from formalin-fixed paraffin-embedded (FFPE) tissues is prone to chemical degradation, affecting mutation detection accuracy. By replacing DNA polymerase with a single strand-specific nuclease P1, researchers improved the performance of duplex sequencing in FFPE-derived DNA, resulting in more accurate mutation detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aleksandr S. Martianov, Natalia V. Mitiushkina, Anastasia N. Ershova, Darya E. Martynenko, Mikhail G. Bubnov, Priscilla Amankwah, Grigory A. Yanus, Svetlana N. Aleksakhina, Vladislav I. Tiurin, Aigul R. Venina, Aleksandra A. Anuskina, Yuliy A. Gorgul, Anna D. Shestakova, Mikhail A. Maidin, Alexey M. Belyaev, Liliya S. Baboshkina, Aglaya G. Iyevleva, Evgeny N. Imyanitov
Summary: This study analyzed the factors influencing the distribution of actionable genetic alterations in colorectal carcinomas. The study found that there were differences in the distribution of certain genetic alterations based on patients' age and gender. BRAF mutation frequency also showed geographic variation. In addition, a small fraction of CRCs had simultaneous alterations in more than one driver gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Anna P. Sokolenko, Elvina Kh. Bakaeva, Aigul R. Venina, Ekaterina Sh. Kuligina, Alexandr A. Romanko, Svetlana N. Aleksakhina, Yana V. Belysheva, Evgeniya V. Belogubova, Ilya A. Stepanov, Olga A. Zaitseva, Olga S. Yatsuk, Alexandr V. Togo, Zaur M. Khamgokov, Azinat O. Kadyrova, Albert Sh. Pirmagomedov, Marina B. Bolieva, Alexandr A. Epkhiev, Aslan K. Tsutsaev, Madina D. Chakhieva, Khalimat M. Khabrieva, Idris M. Khabriev, Mirza A. Murachuev, Bella N. Buttaeva, Liliya S. Baboshkina, Fatima I. Bayramkulova, Islam R. Katchiev, Lina Kh. Alieva, Grigory A. Raskin, Sergey V. Orlov, Zarema K. Khachmamuk, Karine R. Levonyan, Dariya M. Gichko, Dmitriy V. Kirtbaya, Alexey M. Degtyariov, Luisa V. Sultanova, Hedi S. Musayeva, Alexey M. Belyaev, Evgeny N. Imyanitov
Summary: This study reveals the global-wide contribution of BRCA1/2 genes to high-grade serous ovarian cancer (HGSOC) and breast cancer (BC) morbidity in the North Caucasus region, although the spectrum of their pathogenic variants (PVs) shows ethnicity-specific variations. The data on founder BRCA1/2 alleles can be considered when adjusting the testing procedure to the ethnic origin of patients.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Natalia V. Mitiushkina, Vladislav I. Tiurin, Aleksandra A. Anuskina, Natalia A. Bordovskaya, Anna D. Shestakova, Aleksandr S. Martianov, Mikhail G. Bubnov, Anna S. Shishkina, Maria V. Semina, Aleksandr A. Romanko, Ekaterina S. Kuligina, Evgeny N. Imyanitov
Summary: The combination of 3' RACE technology with targeted RNA sequencing panel is an efficient tool for molecular diagnostics of biliary tract carcinomas.
Letter
Oncology
Grigory A. Yanus, Anna P. Sokolenko, Evgeny N. Imyanitov
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Tatiana N. Sokolova, Valeriy V. Breder, Irina S. Shumskaya, Evgeny N. Suspitsin, Svetlana N. Aleksakhina, Grigoriy A. Yanus, Vladislav I. Tiurin, Alexandr O. Ivantsov, Barbara Vona, Grigoriy A. Raskin, Sergey V. Gamajunov, Evgeny N. Imyanitov
Summary: This case highlights the importance of proper interpretation of genetic testing results and the potential impact of family history on cancer treatment decisions. It also demonstrates the need for rigorous clinical expertise in medical laboratory facilities to avoid errors and misinterpretations.
HEREDITARY CANCER IN CLINICAL PRACTICE
(2021)
Article
Genetics & Heredity
Aboulfazl Rad, Thore Schade-Mann, Philipp Gamerdinger, Grigoriy A. Yanus, Bjoern Schulte, Marcus Mueller, Evgeny N. Imyanitov, Saskia Biskup, Hubert Loewenheim, Anke Tropitzsch, Barbara Vona
Summary: COL11A1-encoded alpha-chain collagen molecules are crucial for skeletal, ocular, and auditory function. Variants in COL11A1 have been associated with syndromes affecting these systems. This study provides evidence that splice-altering variants in COL11A1 cause DFNA37 hearing loss, emphasizing the importance of including COL11A1 in genetic testing for nonsyndromic deafness.
