Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model

Finding suitable targets is the major obstacle to cancer gene therapy

(2014) Steven A Rosenberg   CANCER GENE THERAPY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

A Novel Murine T-Cell Receptor Targeting NY-ESO-1

(2014) Shannon F. Rosati et al.   JOURNAL OF IMMUNOTHERAPY

Why is sentinel lymph node biopsy 'standard of care' for melanoma?

(2014) James C. Yang et al.   Nature Reviews Clinical Oncology

HIV-1 Env DNA Vaccine plus Protein Boost Delivered by EP Expands B- and T-Cell Responses and Neutralizing Phenotype In Vivo

(2014) Kar Muthumani et al.   PLoS One

Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity

(2013) Janelle A. Olson et al.   IMMUNITY

Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

(2013) Spyros A. Kalams et al.   JOURNAL OF INFECTIOUS DISEASES

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab

(2013) Kar Muthumani et al.   Human Vaccines & Immunotherapeutics

Highly Optimized DNA Vaccine Targeting Human Telomerase Reverse Transcriptase Stimulates Potent Antitumor Immunity

(2013) J. Yan et al.   Cancer Immunology Research

Comparative analysis of monocytic and granulocytic myeloid-derived suppressor cell subsets in patients with gastrointestinal malignancies

(2012) Austin Duffy et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic Cell-Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells

(2012) Y. Dang et al.   CLINICAL CANCER RESEARCH

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice

(2012) Junjie Mei et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth

(2012) E. Schlecker et al.   JOURNAL OF IMMUNOLOGY

Mouse CD11b + Gr-1 + Myeloid Cells Can Promote Th17 Cell Differentiation and Experimental Autoimmune Encephalomyelitis

(2012) Huanfa Yi et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+ CD25+ FoxP3+ Tregs from CD4+ CD25− FoxP3− T cells

(2012) Sara M. Centuori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

(2012) M. L. Bagarazzi et al.   Science Translational Medicine

Induction of robust cellular immunity against HPV6 and HPV11 in mice by DNA vaccine encoding for E6/E7 antigen

(2012) Thomas Shin et al.   Human Vaccines & Immunotherapeutics

A novel strategy for modulation of MDSC to enhance cancer immunotherapy

(2012) Tomar Ghansah   OncoImmunology

Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor

(2011) Deborah A. Grosenbaugh et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells

(2011) B. Hoechst et al.   BLOOD

CTLA-4 blockade increases antigen-specific CD8+ T cells in prevaccinated patients with melanoma: three cases

(2011) Jianda Yuan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis

(2011) T. Tanikawa et al.   CANCER RESEARCH

Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination

(2011) P Fagone et al.   GENE THERAPY

Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice

(2011) Hong-Shiue Chou et al.   HEPATOLOGY

Meeting report: Regulatory myeloid cells

(2011) Drake LaFace et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MART-1- and gp100-Expressing and -Non-Expressing Melanoma Cells Are Equally Proliferative in Tumors and Clonogenic In Vitro

(2011) Mariana Aris et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

(2011) Je-In Youn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo

(2011) Brian R. Rosborough et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of the MDSC Proteome Associated with Metastatic Murine Mammary Tumors Using Label-Free Mass Spectrometry and Shotgun Proteomics

(2011) Angela M. Boutté et al.   PLoS One

Murine Pancreatic Adenocarcinoma Dampens SHIP-1 Expression and Alters MDSC Homeostasis and Function

(2011) Shari Pilon-Thomas et al.   PLoS One

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A DNA Vaccine against Chikungunya Virus Is Protective in Mice and Induces Neutralizing Antibodies in Mice and Nonhuman Primates

(2011) Karthik Mallilankaraman et al.   PLoS Neglected Tropical Diseases

Multivalent immunity targeting tumor-associated antigens by intra-lymph node DNA-prime, peptide-boost vaccination

(2010) K A Smith et al.   CANCER GENE THERAPY

Immunologic Response to Xenogeneic gp100 DNA in Melanoma Patients: Comparison of Particle-Mediated Epidermal Delivery with Intramuscular Injection

(2010) B. A. Ginsberg et al.   CLINICAL CANCER RESEARCH

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells

(2010) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

Multivalent Smallpox DNA Vaccine Delivered by Intradermal Electroporation Drives Protective Immunity in Nonhuman Primates Against Lethal Monkeypox Challenge

(2010) Lauren A. Hirao et al.   JOURNAL OF INFECTIOUS DISEASES

Proteomic Pathway Analysis Reveals Inflammation Increases Myeloid-Derived Suppressor Cell Resistance to Apoptosis

(2010) Olesya Chornoguz et al.   MOLECULAR & CELLULAR PROTEOMICS

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

(2009) J. Ozao-Choy et al.   CANCER RESEARCH

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

A new tyrosinase epitope recognized in the HLA-B*4002 context by CTL from melanoma patients

(2008) Yann Godet et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Improved Tumor Immunity Using Anti-Tyrosinase Related Protein-1 Monoclonal Antibody Combined with DNA Vaccines in Murine Melanoma

(2008) Y. M. Saenger et al.   CANCER RESEARCH

Phase 1 Trial of Intranodal Injection of a Melan-A/MART-1 DNA Plasmid Vaccine in Patients With Stage IV Melanoma

(2008) Jeffrey Weber et al.   JOURNAL OF IMMUNOTHERAPY

Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma

(2008) Miguel-Angel Perales et al.   MOLECULAR THERAPY

Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques

(2007) Lauren A. Hirao et al.   VACCINE