Article
Hematology
Andrew D. Meyer, Tyler B. Hughes, Anjana R. Rishmawi, Patty Heard, Shafqat Shah, Gregory J. Aune
Summary: Cancer survivors, especially children, have an increased risk of thromboembolism and exhibit a procoagulant state characterized by lower platelet count, shorter prothrombin time, and elevated procoagulant biomarkers such as TAT and PAI. This chronic hypercoagulable state persists for more than five years after diagnosis and may contribute to the increased risk of thromboembolism in childhood cancer survivors.
THROMBOSIS RESEARCH
(2023)
Article
Sport Sciences
Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, Go Tani, Peter T. T. Katzmarzyk, Adam Baxter-Jones, Jose Maia
Summary: This study aimed to analyze the longitudinal trends in children's moderate-to-vigorous physical activity (MVPA) and its associations with individual, familial, and school characteristics. The results showed that MVPA declines from ages 5 to 10 in both boys and girls, with boys consistently being more active than girls. The best predictors for the decline in MVPA were found to be sex, BMI, musculoskeletal fitness, and school playground dimension.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Oncology
John L. Jefferies, Wojciech M. Mazur, Carrie R. Howell, Juan C. Plana, Kirsten K. Ness, Zhenghong Li, Vijaya M. Joshi, Daniel M. Green, Daniel A. Mulrooney, Jeffrey A. Towbin, Hugo R. Martinez, Jason F. Goldberg, Rebecca M. Howell, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Gregory T. Armstrong
Summary: Limited data exist regarding left ventricular remodeling patterns observed in adult survivors of childhood cancer after therapy. Among survivors, chest radiation therapy increases the risk for concentric remodeling while it is associated with decreased exercise intolerance.
Article
Urology & Nephrology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline van Dulmen den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Margreet A. Veening, Arend Bokenkamp
Summary: This study aimed to evaluate glomerular dysfunction among childhood cancer survivors compared to a control group. It found a higher risk of chronic kidney disease and albuminuria in survivors, and identified several risk factors associated with these conditions. Therefore, lifelong monitoring of glomerular function is necessary for these survivors.
KIDNEY INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Cassie Doyle, Eunjeong Ko, Hector Lemus, Fang-Chi Hsu, John P. Pierce, Tianying Wu
Summary: Living alone may increase the risk of mortality among breast cancer survivors, especially those with poor physical health. The study also found different joint effects of living alone and physical health measures on overall mortality, with varying patterns depending on different domains of physical health.
Article
Sport Sciences
Megan E. Ware, Angela Delaney, Kevin R. Krull, Tara M. Brinkman, Gregory T. Armstrong, Carmen L. Wilson, Daniel A. Mulrooney, Zhaoming Wang, Jennifer Q. Lanctot, Matthew R. Krull, Robyn E. Partin, Kyla C. Shelton, Deo kumar Srivastava, Melissa M. Hudson, Leslie L. Robison, Kirsten K. Ness
Summary: This study investigated the relationship between cancer-related worry and objectively assessed physical activity in childhood cancer survivors. The results showed that worry related to bodily function and appearance is associated with decreased physical activity. Clinicians are advised to consider the potential negative impact of cancer-related worry on physical activity levels and provide behavioral counseling.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Oncology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet Van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline Van Dulmen-den Broeder, Marry M. Van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Arend Bokenkamp, Margreet A. Veening
Summary: This study investigated the occurrence of tubular dysfunction in childhood cancer survivors who received nephrotoxic therapy. The overall prevalence of electrolyte losses in survivors was not higher compared to controls, but some survivors had an increased risk of tubular dysfunction, especially those treated with specific chemotherapeutic agents. Therefore, these patients should be closely monitored during follow-up.
Article
Medicine, Research & Experimental
Zhao-yan Liu, Chen Wang, Yao-jun Zhang, Hui-lian Zhu
Summary: In this study, the independent and joint associations of lifestyle and mental health with mortality in cancer survivors were evaluated. The results showed that adopting a healthy lifestyle and maintaining good mental health can improve the survival of cancer survivors. The combination of a higher healthy lifestyle score and better mental health was associated with the lowest mortality.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pediatrics
Mari Bratteteig, Sigmund Alfred Anderssen, Corina Silvia Rueegg, Ellen Ruud, Ingrid Kristin Torsvik, Susi Kriemler, May Grydeland
Summary: This study aimed to compare cardiovascular disease (CVD) risk factors in childhood cancer survivors (CCS) with reference values and explore the association between physical activity (PA) intensities and CVD risk factors in CCS. The study found that male CCS had less favorable values of CVD risk factors compared to reference values, and vigorous-intensity PA was associated with clinically meaningful favorable values of CVD risk factors.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Erika Rees-Punia, Alpa Patel, Joseph R. Nocera, Sicha Chantaprasopsuk, Wendy Demark-Wahnefried, Corinne R. Leach, Tenbroeck G. Smith, David Cella, Susan M. Gapstur
Summary: The study found that increasing MVPA and reducing sitting time are crucial for improving health in older adults, regardless of prior cancer diagnosis.
Review
Oncology
Sophie Van Dijck, An De Groef, Janan Kothari, Lore Dams, Vincent Haenen, Nathalie Roussel, Mira Meeus
Summary: Barriers and facilitators to physical activity in cancer survivors with pain can be categorized into six domains: logistical, symptoms, cognitive, clinical, social, and knowledge domain. The barrier of pain distinguishes itself and brings along additional obstacles such as anxiety, fear, and avoidance behavior. Current evidence is limited and mostly focused on female breast cancer survivors. Further research in larger cohorts representing various subsets of cancer survivors with pain is needed, as well as studies that implement these insights in physical activity interventions.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Kimberly W. Keefe, Andrea Lanes, Kayla Stratton, Daniel M. Green, Eric J. Chow, Kevin C. Oeffinger, Sara Barton, Lisa Diller, Yutaka Yasui, Wendy M. Leisenring, Gregory T. Armstrong, Elizabeth S. Ginsburg
Summary: Linking the Childhood Cancer Survivor Study database to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System revealed that childhood cancer survivors are as likely to undergo treatment with assisted reproductive technology as their siblings. The success of assisted reproductive technology was not reduced after alkylator exposure.
Article
Oncology
S. Michael, A. Borgmann-Staudt, G. Sommerhaeuser, K. Kepakova, S. Klco-Brosius, J. Kruseova, E. Nagele, A. Panasiuk, J. Vetsch, M. Balcerek
Summary: This study examined the educational and vocational pathways of childhood cancer survivors and their siblings using the International Standard Classification of Education (ISCED). The results showed that childhood cancer and treatment did not have an impact on the educational pathways chosen by parents after becoming survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Medicine, General & Internal
Tuo Lan, Mei Wang, Matthew J. J. Ehrhardt, Shu Jiang, Jennifer Q. Q. Lanctot, Gregory T. T. Armstrong, Melissa M. M. Hudson, Graham A. A. Colditz, Leslie L. L. Robison, Yikyung Park
Summary: This study examines the associations between dietary patterns and cardiovascular disease risk in adult survivors of childhood cancer. The findings suggest that adhering to healthy dietary patterns, such as the Healthy Eating Index (HEI-2015), DASH, and aMED, may lower the risk of cardiovascular disease, particularly in women. These results indicate that a diet rich in plant foods and moderate in animal foods should be recommended for the management and prevention of cardiovascular disease in childhood cancer survivors.
Article
Oncology
Nina S. Kadan-Lottick, Daniel J. Zheng, Mingjuan Wang, Michael W. Bishop, Deo Kumar Srivastava, Wilhelmenia L. Ross, Rozalyn L. Rodwin, Kirsten K. Ness, Todd M. Gibson, Sheri L. Spunt, Mehmet Fatih Okcu, Wendy M. Leisenring, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull
Summary: This study examined the long-term neurocognitive outcomes of survivors of childhood osteosarcoma and Ewing sarcoma. The results showed that these survivors are more likely to report neurocognitive difficulties, which are related to employment status and chronic health conditions. Therefore, early screening, prevention, and treatment of chronic health conditions may be important for improving/preventing long-term neurocognitive outcomes.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Orthopedics
Erik J. Geiger, Wei Liu, Deo Kumar Srivastava, Nicholas M. Bernthal, Brent R. Weil, Yutaka Yasui, Kirsten K. Ness, Kevin R. Krull, Robert E. Goldsby, Kevin C. Oeffinger, Leslie L. Robison, Bryan V. Dieffenbach, Christopher B. Weldon, Mark C. Gebhardt, Rebecca Howell, Andrew J. Murphy, Wendy M. Leisenring, Gregory T. Armstrong, Eric J. Chow, Rosanna L. Wustrack
Summary: This study found that both early amputation and late amputation are associated with decreased physical health-related quality of life outcomes in children with sarcoma. Therefore, interventions should be implemented to improve physical function and help patients achieve educational and employment milestones.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Hematology
Lucie M. Turcotte, Jillian A. Whitton, Wendy M. Leisenring, Rebecca M. Howell, Joseph P. Neglia, Rachel Phelan, Kevin C. Oeffinger, Kirsten K. Ness, William G. Woods, E. Anders Kolb, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow
Summary: The five-year survival rate for childhood acute myeloid leukemia (AML) has increased due to advancements in treatment and supportive care. However, the long-term health outcomes of AML survivors remain unclear. This study examined the incidence of late mortality and chronic health conditions (CHC) among 5-year AML survivors diagnosed between 1970 and 1999. The results showed that hematopoietic cell transplantation (HCT) was associated with higher late mortality, but the incidence of CHC has decreased over time for all treatment groups.
Article
Oncology
Paul C. Nathan, I-Chan Huang, Yan Chen, Tara O. Henderson, Elyse R. Park, Anne C. Kirchhoff, Leslie L. Robison, Kevin Krull, Wendy Leisenring, Gregory T. Armstrong, Rena M. Conti, Yutaka Yasui, K. Robin Yabroff
Summary: This study aimed to estimate the prevalence of financial hardship among adult survivors of childhood cancer compared with siblings and identify the correlates of hardship. The results showed that survivors were more likely to experience financial hardship compared to siblings.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Hyewon Shin, William N. Dudley, Nickhill Bhakta, Madeline R. Horan, Zhaoming Wang, T. Robin Bartlett, Deokumar Srivastava, Yutaka Yasui, Justin N. Baker, Leslie L. Robison, Kirsten K. Ness, Kevin R. Krull, Melissa M. Hudson, I-Chan Huang
Summary: The purpose of this study was to identify symptom clusters among adult survivors of childhood cancers and test their associations with health-related quality of life (HRQOL) and physical and neurocognitive performance. The study identified four clusters of symptoms, and survivors with higher symptom burden were associated with sociodemographic characteristics, treatment factors, HRQOL, and functional outcomes.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chiara Papini, Ameera A. Fayad, Mingjuan Wang, Fiona S. M. Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M. Howell, Deokumar Srivastava, Wendy M. Leisenring, Gregory T. Armstrong, Todd M. Gibson, Leslie L. Robison, Kevin C. Oeffinger, Kevin R. Krull, Tara M. Brinkman
Summary: Young adult survivors of childhood cancer have an increased risk of loneliness, which can lead to physical and mental health issues in the future.
Article
Oncology
AnnaLynn M. Williams, Jeanne Mandelblatt, Mingjuan Wang, Gregory T. Armstrong, Nickhill Bhakta, Tara M. Brinkman, Wassim Chemaitilly, Matthew J. Ehrhardt, Daniel A. Mulrooney, Brent J. Small, Zhaoming Wang, Deokumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness, Kevin R. Krull
Summary: This study aimed to compare the accumulation of deficits in survivors of pediatric cancer with community controls and examine associations with host and treatment factors, neurocognition, and mortality. The results showed that pediatric cancer survivors experience clinically significant premature aging, with a DAI score of 0.16 at age 30 corresponding to age 63 in controls (33 years premature aging). Higher DAI scores were associated with increased risk of neurocognitive impairment and death.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Oncology
Madeline R. Horan, Jin-ah Sim, Kevin R. Krull, Kirsten K. Ness, Yutaka Yasui, Leslie L. Robison, Melissa M. Hudson, Justin N. Baker, I-Chan Huang
Summary: Patient-reported outcome measures (PROMs) are useful in assessing the subjective experiences of childhood cancer survivors and can be used to monitor health status and inform medical decision making. This article provides 10 important considerations for clinicians when assessing PROMs for childhood cancer survivors, addressing practical barriers and solutions. An example framework for integrating PROMs into clinical workflow using cutting-edge technologies is also discussed.
Article
Oncology
Fang Fang Zhang, Melissa M. M. Hudson, Fan Chen, Zhongyu Li, I-Chan Huang, Nickhill Bhakta, Kirsten K. K. Ness, Tara M. M. Brinkman, James Klosky, Rohit P. P. Ojha, Jennifer Q. Q. Lanctot, Leslie L. L. Robison, Kevin R. R. Krull
Summary: Adult survivors of childhood cancer have poor adherence to nutrition guidelines and inadequate intake of certain vitamins and minerals. The use of dietary supplements is common among these survivors. However, it is associated with both inadequate and excessive nutrient intake, and positively impacts certain aspects of quality of life.
Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Oncology
Adam J. Esbenshade, Lu Lu, Debra L. Friedman, Kevin C. Oeffinger, Gregory T. Armstrong, Kevin R. Krull, Joseph P. Neglia, Wendy M. Leisenring, Rebecca Howell, Robyn Partin, Amy Sketch, Leslie L. Robison, Kirsten K. Ness
Summary: Using a geriatric rating scale, researchers found that childhood cancer survivors accumulate diseases at a faster rate compared to their siblings and the general population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
James E. Bates, Suman Shrestha, Qi Liu, Susan A. Smith, Daniel A. Mulrooney, Wendy Leisenring, Todd Gibson, Leslie L. Robison, Eric J. Chow, Kevin C. Oeffinger, Gregory T. Armstrong, Louis S. Constine, Bradford S. Hoppe, Choonsik Lee, Yutaka Yasui, Rebecca M. Howell
Summary: Radiation-associated cardiac disease is a major concern for childhood cancer survivors, with potential risks to cardiac substructures from radiotherapy. There may be no threshold dose below which radiation to the cardiac substructures does not increase the risk of cardiac diseases, highlighting the need for careful treatment planning.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chiara Papini, Sedigheh Mirzaei S., Mengqi Xing, Ingrid Tonning Olsson, Peter M. K. de Blank, Katharine R. Lange, Ralph Salloum, Deokumar Srivastava, Wendy M. Leisenring, Rebecca M. Howell, Kevin C. Oeffinger, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull, Tara M. Brinkman
Summary: The associations between treatment changes and neurocognition, as well as the contribution of neurocognition and chronic health conditions to attainment of adult independence, remain unknown in childhood glioma survivors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Jason F. Goldberg, Geehong Hyun, Kirsten K. Ness, Stephanie B. Dixon, Jeffrey A. Towbin, Isaac B. Rhea, Matthew J. Ehrhardt, Deo Kumar Srivastava, Daniel A. Mulrooney, Melissa M. Hudson, Leslie L. Robison, John L. Jefferies, Anand Rohatgi, Gregory T. Armstrong
Summary: Childhood cancer survivors have a higher prevalence of dyslipidemia, which is associated with increased risk of cardiovascular disease. Therefore, comprehensive evaluation and treatment of lipid abnormalities are needed to reduce the incidence of cardiovascular morbidity in this population.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)