Article
Biochemistry & Molecular Biology
Izabela Kokot, Agnieszka Piwowar, Marcin Jedryka, Ewa Maria Kratz
Summary: The study found that serum concentrations of FRAP, telomerase and AOPP were significantly higher in patients with endometriosis and other gynecological disorders, indicating their potential as promising diagnostic markers for endometriosis.
Article
Biochemistry & Molecular Biology
Tomasz Palka, Piotr Michal Koteja, Lukasz Tota, Lukasz Rydzik, Alejandro Leiva-Arcas, Anna Kaluza, Wojciech Czarny, Tadeusz Ambrozy
Summary: This study aimed to examine the effectiveness of different hydration strategies in young men during prolonged exercise at elevated ambient temperatures on levels of oxidative stress, antioxidant status, muscle cell damage, and inflammatory status. The results showed that using isotonic drinks instead of water or no hydration effectively protected muscle cells from the negative effects of exercise.
Review
Biochemistry & Molecular Biology
Naser A. Alsharairi
Summary: This review summarizes the research on the relationship between asthma and oxidative stress, indicating significant differences in oxidative stress and inflammation markers between smokers and nonsmokers. It also emphasizes the need for further studies on the association between antioxidant intake and asthma, as well as its associated biomarkers.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Environmental Sciences
Beatriz Alvarez-Gonzalez, Patricia Porras-Quesada, Veronica Arenas-Rodriguez, Alba Tamayo-Gomez, Fernando Vazquez-Alonso, Luis Javier Martinez-Gonzalez, Antonio F. Hernandez, Maria Jesus Alvarez-Cubero
Summary: The development and progression of prostate cancer are influenced by the interaction between genetic, environmental, and dietary factors. Chemical exposures and genetic polymorphisms in genes encoding xenobiotic metabolizing enzymes, antioxidant enzymes, and DNA repair enzymes play a major role in cancer development. Understanding the causal risk factors for prostate cancer can help identify high-risk individuals and develop effective detection and prevention methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Sudarsanan Drishya, Suresh Sulekha Dhanisha, Paramu Raghukumar, Chandrasekharan Guruvayoorappan
Summary: The study demonstrates the radioprotective efficacy of methanolic extract of Amomum subulatum dry fruits in mice, showing its potential in enhancing antioxidant defense mechanisms, preventing hematopoietic damages, and reducing inflammatory responses.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Agata Leonska-Duniec, Malgorzata Borczyk, Michal Korostynski, Myosotis Massidda, Ewelina Maculewicz, Pawel Cieszczyk
Summary: This study investigated the association between genetic variations in the MSTN, ACVR2A, and ACVR2B genes and athletic performance and competition level in the Polish population. The findings suggest that specific genotypes of these genes are significantly associated with athletes' competition level, particularly in the mixed-sports athlete group.
Article
Multidisciplinary Sciences
William D. Dupont, Joan P. Breyer, Spenser H. Johnson, W. Dale Plummer, Jeffrey R. Smith
Summary: The study found that the G84E germline mutation of HOXB13 predisposes to prostate cancer, and multiple rare genetic variants in European-ancestry case-control study populations have significant effects on prostate cancer risk. Independent risk signals were mainly detected from specific variants within SKAP1 and HOXB13.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Yichao Ma, Shuang Zhang, Liyan Rong, Zhaoxia Wu, Wentao Sun
Summary: This study reported the polyphenol content and antioxidant activity of nine brown and white japonica rice cultivars. The polyphenol and flavonoid contents were significantly higher in brown rice compared to white rice, and brown rice also had stronger antioxidant capacities.
Review
Biochemistry & Molecular Biology
Agnieszka Wolnicka-Glubisz, Anna Wisniewska-Becker
Summary: Curcumin, a natural polyphenol with antioxidant properties, can have therapeutic effects on different disorders. However, it can also be toxic under certain conditions, such as exposure to blue light or excessive use.
Article
Nutrition & Dietetics
Beatriz Navajas-Porras, Sergio Perez-Burillo, Daniel Hinojosa-Nogueira, Konstantinos Douros, Silvia Pastoriza, Jose Angel Rufian-Henares
Summary: The digestion and microbial activity in the gut produce molecules with potential antioxidant capacity from food. Different foods contribute differently to daily antioxidant intake, and gut microbiota may play a greater role in determining food antioxidant capacity in certain individuals.
Article
Biochemistry & Molecular Biology
Paula C. Silveira-Silva, Robson E. Silva, Eliziaria C. Santos, Patricia B. I. Justino, Margarida P. Santos, Reggiani Goncalves, Romulo D. Novaes
Summary: Controlling systemic proinflammatory and prooxidant effectors is crucial for reducing cardiovascular risk and mortality in patients with end-stage renal disease (ESRD). However, monitoring these processes is challenging due to limited understanding of their determinants and predictors. This study investigated the relationship between advanced glycosylation end products (AGE) and proinflammatory and prooxidant effectors in ESRD patients undergoing hemodialysis (HD). The results showed that AGE accumulation was associated with elevated proinflammatory and prooxidant markers, suggesting that monitoring AGE levels may help predict systemic inflammatory stress and the balance between oxidant and antioxidant status in ESRD patients.
Article
Agriculture, Dairy & Animal Science
A. Zsolnai, I Egerszegi, L. Rozsa, I Anton
Summary: The study analyzed the genome of Racka sheep using Geneseek Ovine SNP50 BeadChip, revealing genetic differences between Black and White Racka. Differences were also observed in the number of Runs of Homozygosity and inbreeding coefficients. The findings help recognize Racka as a unique genetic resource among sheep.
Article
Oncology
Hui-Yi Lin, Tung-Sung Tseng, Xinnan Wang, Zhide Fang, Arnold H. Zea, Liang Wang, Julio Pow-Sang, Catherine M. Tangen, Phyllis J. Goodman, Alicja Wolk, Niclas Hakansson, Manolis Kogevinas, Javier Llorca, Hermann Brenner, Ben Schoettker, Jose Esteban Castelao, Manuela Gago-Dominguez, Marija Gamulin, Davor Lessel, Frank Claessens, Steven Joniau, Jong Y. Park
Summary: This study aimed to evaluate the intake patterns of total alcohol and three types of alcoholic beverage (beer, wine, and spirits) in relation to prostate cancer risk and aggressiveness. The study found that prostate cancer patients were more likely to consume wine and spirits, while patients with aggressive prostate cancer drank more beer. Interestingly, heavy wine intake was inversely associated with prostate cancer aggressiveness.
Article
Medicine, General & Internal
Shiva Ganjali, Reihaneh Keshavarz, Susan Hosseini, Atena Mansouri, Massimo R. Mannarino, Matteo Pirro, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This study revealed significant differences in oxidant/antioxidant markers between FH patients and healthy individuals, as well as between HoFH and HeFH patients. These differences may be strongly associated with plasma LDL-C levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Margaret Murray, Sophie Selby-Pham, Beau-Luke Colton, Louise Bennett, Gary Williamson, L. Aimee Dordevic
Summary: This systematic review investigated the effect of timing of phytonutrient intake on blood markers of postprandial oxidative processes. The results showed that phytonutrients consumed with a HFHC meal significantly suppressed some markers of oxidative stress in blood, but further studies are needed to confirm the observations and systematically optimize the effect of timing.
Article
Oncology
Josien C. A. Jenniskens, Kelly Offermans, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the association between energy balance-related factors and Warburg subtypes in colorectal cancer. The results indicate that BMI, clothing size, and physical activity are associated with different risks of colon cancer subtypes. The Warburg effect may play a role in the relationship between adiposity and colon cancer risk, with potential additional mechanisms in women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Evan Yi-Wen Yu, Mariana C. Stern, Xuejuan Jiang, Li Tang, Piet A. van den Brandt, Chih-Ming Lu, Margaret R. Karagas, Carlo La Vecchia, Cristina Bosetti, Jerry Polesel, Klaus Golka, Zuo-Feng Zhang, Paul Villeneuve, Maurice P. Zeegers, Anke Wesselius
Summary: This study based on worldwide case-control studies found a positive association between family history of bladder cancer in first- and second-degree relatives, as well as nonurologic cancers, and bladder cancer risk. The number of first-degree relatives affected by cancer also increased the risk of bladder cancer.
CANCER PREVENTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: This study examined the association between adherence to the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) recommendations and risk of Cancer of Unknown Primary (CUP). The findings suggest that highest adherence to the recommendations is not statistically significantly associated with decreased CUP risk after multivariable adjustment.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Iris W. A. Boot, Anke Wesselius, Evan Y. W. Yu, Maree Brinkman, Piet van den Brandt, Eric J. Grant, Emily White, Elisabete Weiderpass, Pietro Ferrari, Matthias B. Schulze, Bas Bueno-de-Mesquita, Maria Jose-Sanchez, Bjorn Gylling, Maurice P. Zeegers
Summary: This study found that B group vitamins may play a role in preventing bladder cancer, and different genders have different associations between the intake of various vitamins and bladder cancer risk.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Oncology
Josien C. A. Jenniskens, Kelly Offermans, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: Early-life energy balance-related factors are associated with adult colorectal cancer risk, possibly through the activation of the Warburg effect. Height, BMI, and energy restriction proxies during early life are associated with different subtypes of Warburg effect in colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Mostafa Dianatinasab, Anke Wesselius, Amin Salehi-Abargouei, Evan Y. W. Yu, Mohammad Fararouei, Maree Brinkman, Piet van den Brandt, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc J. Gunter, Inge Huybrechts, Maurice P. Zeegers
Summary: This study investigated the association between fat intake and bladder cancer risk using data from 11 cohort studies. It found an inverse association between mono-unsaturated fatty acids (MUFAs) intake and bladder cancer risk among women, and a positive association between higher dietary cholesterol intake and bladder cancer risk among men.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Mary K. Townsend, Britton Trabert, Renee T. Fortner, Alan A. Arslan, Julie E. Buring, Brian D. Carter, Graham G. Giles, Sarah R. Irvin, Michael E. Jones, Rudolf Kaaks, Victoria A. Kirsh, Synnove F. Knutsen, Woon-Puay Koh, James Lacey, Hilde Langseth, Susanna C. Larsson, I-Min Lee, Maria Elena Martinez, Melissa A. Merritt, Roger L. Milne, Katie M. O'Brien, Michael J. Orlich, Julie R. Palmer, Alpa Patel, Ulrike Peters, Jenny N. Poynter, Kim Robien, Thomas E. Rohan, Lynn Rosenberg, Sven Sandin, Dale P. Sandler, Leo J. Schouten, V. Wendy Setiawan, Anthony J. Swerdlow, Giske Ursin, Piet A. van den Brandt, Kala Visvanathan, Elisabete Weiderpass, Alicja Wolk, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Shelley S. Tworoger, Nicolas Wentzensen
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Chiara Stival, Alessandra Lugo, Lavinia Barone, Giovanni Fattore, Anna Odone, Silvia Salvatore, Eugenio Santoro, Silvia Scaglioni, Piet A. van den Brandt, Silvano Gallus
Summary: Investigating the relationship between pediatric overweight, physical activity, and various factors is crucial for designing effective preventive programs. This study utilized data from surveys conducted in Lombardy, northern Italy in 2019. The prevalence of overweight and obesity was found to be 22.4% among 8-9-year-old children and 14.4% among 11-15-year-old adolescents. Males, children with higher birth weights, and those with obese parents had higher rates of overweight. Females and older adolescents were more likely to engage in inadequate physical activity. Obesity was associated with increased psychological distress and being victims of bullying. Increasing physical activity was found to decrease the frequency of mental health problems. Promoting prevention campaigns is necessary to ensure the physical and psychological well-being of children.
Article
Multidisciplinary Sciences
Jeroen A. A. van de Pol, Paranita Ferronika, Helga Westers, Manon van Engeland, Martijn M. Terpstra, Kim M. Smits, Kim de Lange, Piet A. van den Brandt, Rolf H. Sijmons, Leo J. Schouten, Klaas Kok
Summary: This study investigates the influence of seven frequently mutated genes on cancer-specific survival in clear cell renal cell cancer. Mutations in VHL and PBRM1 were associated with better survival, but the results were not statistically significant after multiple testing correction. No association was observed for the other five genes, possibly due to limited power.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Alicia K. Heath, David C. Muller, Piet A. van den Brandt, Elena Critselis, Marc Gunter, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Pietro Ferrari, Melissa A. Merritt, Agnetha L. Rostgaard-Hansen, Anne Tjonneland, Kim Overvad, Verena Katzke, Bernard Srour, Giovanna Masala, Carlotta Sacerdote, Fulvio Ricceri, Fabrizio Pasanisi, Bas Bueno-de-Mesquita, George S. Downward, Guri Skeie, Torkjel M. Sandanger, Marta Crous-Bou, Miguel Rodriguez-Barranco, Pilar Amiano, Jose Maria Huerta, Eva Ardanaz, Isabel Drake, Mikael Johansson, Ingegerd Johansson, Tim Key, Nikos Papadimitriou, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis
Summary: The association between diet and lung cancer risk, particularly with specific foods or nutrients, remains unclear. This study found that higher intake of fiber, fruit, and vitamin C were associated with a lower risk of lung cancer, while higher intake of offal, retinol, and beer/cider were positively associated with lung cancer risk. The associations were not different between sexes and were less significant among never smokers. The associations found in this study were not replicated in a separate cohort study, except for the inverse associations of fruit and vitamin C with squamous cell carcinoma.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Chiara Stival, Alessandra Lugo, Anna Odone, Piet A. van den Brandt, Esteve Fernandez, Olena Tigova, Joan B. Soriano, Maria Jose Lopez, Silvia Scaglioni, Silvano Gallus
Summary: Based on the data from the TackSHS survey, this study provides updated estimates of the prevalence and determinants of overweight and obesity in Europe. The results show that overweight and obesity are highly prevalent in Europe, particularly in Eastern and Northern European countries. Moreover, there has been an increasing trend in obesity prevalence in these regions compared to 2010.
Review
Clinical Neurology
Carlotta M. Jarach, Alessandra Lugo, Marco Scala, Piet A. van den Brandt, Christopher R. Cederroth, Anna Odone, Werner Garavello, Winfried Schlee, Berthold Langguth, Silvano Gallus
Summary: This systematic review and meta-analysis provides frequency estimates of tinnitus worldwide. The study shows that tinnitus affects more than 740 million adults globally, with over 120 million people considering it a major problem, mostly among those aged 65 years or older. The prevalence of tinnitus does not differ by sex, but increases with age.
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the prognostic value of mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, MET, and mismatch repair (MMR) status in colorectal cancer (CRC) patients. The results showed that mutational subgroups were associated with survival differences in CRC patients, while Warburg-subtypes did not provide additional prognostic information within these mutational subgroups.
Article
Nutrition & Dietetics
Marta Crous-Bou, Mengmeng Du, Marc J. Gunter, Veronica W. Setiawan, Leo J. Schouten, Xiao-ou Shu, Nicolas Wentzensen, Kimberly A. Bertrand, Linda S. Cook, Christine M. Friedenreich, Susan M. Gapstur, Marc T. Goodman, Torukiri I. Ibiebele, Carlo La Vecchia, Fabio Levi, Linda M. Liao, Eva Negri, Susan E. McCann, Kelly O'Connell, Julie R. Palmer, Alpa Patel, Jeanette Ponte, Peggy Reynolds, Carlotta Sacerdote, Rashmi Sinha, Amanda B. Spurdle, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Stacey Petruzella, Sara H. Olson, Immaculata De Vivo
Summary: Epidemiologic studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. The largest pooled analysis to date further supports the potentially beneficial health effects of coffee consumption in relation to EC.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Silvano Gallus, Alessandra Lugo, Chiara Stival, Sonia Cerrai, Luke Clancy, Filippos T. Filippidis, Giuseppe Gorini, Maria Jose Lopez, Angel Lopez-Nicolas, Sabrina Molinaro, Anna Odone, Joan B. Soriano, Olena Tigova, Piet A. van den Brandt, Constantine I. Vardavas, Esteve Fernandez
Summary: According to the survey conducted by the TackSHS project, over 8.3 million adults in 12 European countries use electronic cigarettes. The majority of users are dual users, using both electronic and conventional cigarettes, using electronic cigarettes with nicotine, and using them in smoke-free indoor areas.
JOURNAL OF EPIDEMIOLOGY
(2023)
