Article
Oncology
Yingzhu Yang, Chiyuan Yu, Rongrong Fu, Shishan Xia, Haixiang Ni, Yujing He, Keying Zhu, Qian Sun
Summary: Recent studies suggest that children born via cesarean section have an increased risk of immune-mediated diseases later in life. This meta-analysis investigated the association between cesarean section and childhood leukemia, and found that cesarean section is associated with a higher risk of childhood leukemia, particularly acute lymphoblastic leukemia. Notably, elective cesarean section was found to significantly increase the risk of acute lymphoblastic leukemia.
HEMATOLOGICAL ONCOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Janine-Alison Schmidt, Sabine Hornhardt, Friederike Erdmann, Isidro Sanchez-Garcia, Ute Fischer, Joachim Schuez, Gunde Ziegelberger
Summary: Childhood leukemia is caused by a multifactorial process involving genetic and environmental factors, with infections playing a significant role as an environmental risk factor. Studies using mouse models have shown the importance of gene-environment interactions in the development of leukemia, emphasizing the need for further investigation into such interactions.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Andrew Nguyen, Catherine M. Crespi, Ximena Vergara, Nicholas Chun, Leeka Kheifets
Summary: The study found that children born very close to commercial plant nurseries, particularly those within 75 meters, are at increased risk of developing childhood leukemia, especially acute lymphocytic leukemia. The association was robust to choices of reference group, cut points, and data quality, suggesting that further evaluation of this relationship is warranted.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Philip J. Lupo, Tiffany M. Chambers, Beth A. Mueller, Jacqueline Clavel, John D. Dockerty, David R. Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E. Heck, Claire Infante-Rivard, Alice Y. Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D. Bailey, Ana M. Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S. Pombo-de-Oliveira, Wafaa M. Rashed, Eve Roman, Joachim Schuz, Catharina Wesseling, Logan G. Spector, Michael E. Scheurer
Summary: The study explores the associations between nonchromosomal birth defects and childhood leukemia using data from the Childhood Cancer and Leukemia International Consortium. The results suggest possible novel genetic and environmental factors associated with birth defects that may also increase leukemia susceptibility.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Respiratory System
Gozde Gurdeniz, Madeleine Ernst, Daniela Rago, Min Kim, Julie Courraud, Jakob Stokholm, Klaus Bonnelykke, Anders Bjorkbom, Urvish Trivedi, Soren J. Sorensen, Susanne Brix, David Hougaard, Morten Rasmussen, Arieh S. Cohen, Hans Bisgaard, Bo Chawes
Summary: Cesarean section is related to newborn metabolomic profiles, gut microbiome data, and cord blood immunology, indicating an increased risk of childhood asthma.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Shiue-Shan Weng, Yen-Tsung Huang, Yi-Ting Huang, Yi-Ping Li, Li-Yin Chien
Summary: The use of assisted reproductive technology (ART) is associated with an increased risk of childhood cancers, independent of preterm birth and low birth weight.
Article
Oncology
Lindsay A. Williams, Michaela Richardson, Logan G. Spector, Erin L. Marcotte
Summary: The study found that cesarean section is associated with an increased risk of acute lymphoblastic leukemia and hepatoblastoma, especially among females and in specific age groups. Further investigation is needed to determine causality and rule out confounding factors. The mechanisms underlying these associations may involve alterations in the neonatal immune system processes during cesarean deliveries.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Environmental Sciences
Mary H. Ward, Jessica M. Madrigal, Rena R. Jones, Melissa C. Friesen, Roni T. Falk, David Koebel, Catherine Metayer
Summary: Based on the California Childhood Leukemia Study, this research evaluated the relationship between residential pesticide use and the risk of childhood acute lymphoblastic leukemia (ALL). The study found that glyphosate concentrations in house dust were associated with occupational pesticide exposure, nearby agricultural use, treatment for lawn weeds and bees/wasps, and sampling season. However, increasing glyphosate concentrations were not associated with an increased ALL risk. This study highlights the potential risk of young children being exposed to pesticides in residential settings and the need for further research.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Marcella Malavolti, Carlotta Malagoli, Tommaso Filippini, Lauren A. Wise, Alessio Bellelli, Giovanni Palazzi, Monica Cellini, Sofia Costanzini, Sergio Teggi, Marco Vinceti
Summary: A case-control study found that living close to a petrol station, especially one with more frequent refueling activity, was associated with an increased risk of childhood leukemia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Pediatrics
Pernilla Lif Holgerson, Anders Esberg, Christina E. West, Ingegerd Johansson
Summary: This study characterized the microbiota of breast milk, saliva, and fecal samples in preschool children. The results showed distinct microbiota profiles in these sources, with increasing resemblance between breast milk and the oral microbiota by increasing age. The study also found associations between the microbiota composition and diseases such as caries, otitis media, and allergic disease.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Matthew Mclaughlin, Andrea Nathan, Ashleigh Thornton, Jasper Schipperijn, Stewart G. Trost, Hayley Christian
Summary: This study described the adaptations made to the implementation support strategies of the Play Active intervention during scale-up and examined their impact on intervention effectiveness. The results showed that the adaptations primarily focused on the content and delivery mode of the implementation strategies, and most of them had a positive or neutral effect on the intervention effectiveness.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Hematology
Sofie Gottschalk Hojfeldt, Kathrine Grell, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur G. Jonsson, Thomas L. Frandsen, Benjamin O. Wolthers, Hanne Vibeke Marquart, Goda Vaitkeviciene, Kristi Lepik, Mats Heyman, Kjeld Schmiegelow, Birgitte Klug Albertsen
Summary: Truncation of asparaginase treatment due to toxicity or silent inactivation may increase relapse risk in children with acute lymphoblastic leukemia, highlighting the importance of therapeutic drug monitoring and appropriate adjustment of therapy.
Article
Environmental Sciences
Leslie T. Stayner, Jorg Schullehner, Birgitte Dige Semark, Anja Sondergaard Jensen, Betina B. Trabjerg, Marie Pedersen, Jorn Olsen, Birgitte Hansen, Mary H. Ward, Rena R. Jones, Vanessa R. Coffman, Carsten B. Pedersen, Torben Sigsgaard
Summary: The study found that exposure to nitrate from drinking water may increase the risk of childhood central nervous system cancers, but not leukemia or lymphoma.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Christina-Evmorfia Kampitsi, Ann Nordgren, Hanna Mogensen, Emeli Ponten, Maria Feychting, Giorgio Tettamanti
Summary: Neurocutaneous syndromes are associated with an increased risk of childhood cancer, especially central nervous system tumors. Several perinatal factors have lesser associations with childhood cancer, independently of the presence of neurocutaneous syndromes.
Article
Oncology
Jeremy M. Schraw, Helen D. Bailey, Audrey Bonaventure, Ana M. Mora, Eve Roman, Beth A. Mueller, Jacqueline Clavel, Eleni T. Petridou, Maria Karalexi, Evangelia Ntzani, Sameera Ezzat, Wafaa M. Rashed, Erin L. Marcotte, Logan G. Spector, Catherine Metayer, Alice Y. Kang, Corrado Magnani, Lucia Miligi, John D. Dockerty, Juan Manuel Mejia-Arangure, Juan Carlos Nunez-Enriquez, Claire Infante-Rivard, Elizabeth Milne, Michael E. Scheurer
Summary: Growing evidence suggests that breastfeeding may have a protective effect against childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This study analyzed data from multiple studies and found that longer breastfeeding duration is associated with decreased odds of ALL and AML.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemical Research Methods
Yukiko Yano, Hasmik Grigoryan, Courtney Schiffman, William Edmonds, Lauren Petrick, Katie Hall, Todd Whitehead, Catherine Metayer, Sandrine Dudoit, Stephen Rappaport
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2019)
Letter
Hematology
Amalie B. Nielsen, Mi Zhou, Adam J. de Smith, Rong Wang, Lucie McCoy, Helen Hansen, Libby Morimoto, Kirsten Gronbaek, Christoffer Johansen, Scott C. Kogan, Catherine Metayer, Paige M. Bracci, Xiaomei Ma, Joseph L. Wiemels
Article
Endocrinology & Metabolism
Chenan Zhang, Helen M. Hansen, Eleanor C. Semmes, Julio Gonzalez-Maya, Libby Morimoto, Qingyi Wei, William C. Eward, Suzanne B. DeWitt, Jillian H. Hurst, Catherine Metayer, Adam J. de Smith, Joseph L. Wiemels, Kyle M. Walsh
Article
Public, Environmental & Occupational Health
Catherine Enders, Rebecca J. Hyde, Steve Selvin, Catherine Metayer, Stephen Starko Francis
Article
Oncology
Yukiko Yano, Courtney Schiffman, Hasmik Grigoryan, Josie Hayes, William Edmands, Lauren Petrick, Todd Whitehead, Catherine Metayer, Sandrine Dudoit, Stephen Rappaport
Article
Oncology
Ivo S. Muskens, Adam J. de Smith, Chenan Zhang, Helen M. Hansen, Libby Morimoto, Catherine Metayer, Xiaomei Ma, Kyle M. Walsh, Joseph L. Wiemels
Article
Public, Environmental & Occupational Health
Libby M. Morimoto, Marilyn L. Kwan, Kamala Deosaransingh, Julie R. Munneke, Alice Y. Kang, Charles Quesenberry, Scott Kogan, Adam J. de Smith, Catherine Metayer, Joseph L. Wiemels
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Oncology
Joseph L. Wiemels, Rong Wang, Qianxi Feng, Cassandra J. Clark, James F. Amatruda, Elyssa Rubin, Amy C. Yee, Libby M. Morimoto, Catherine Metayer, Xiaomei Ma
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Maria A. Karalexi, Nick Dessypris, Xiaomei Ma, Logan G. Spector, Erin Marcotte, Jacqueline Clavel, Maria S. Pombo-de-Oliveira, Julia E. Heck, Eve Roman, Beth A. Mueller, Johnni Hansen, Anssi Auvinen, Pei-Chen Lee, Joachim Schuz, Corrado Magnani, Ana M. Mora, John D. Dockerty, Michael E. Scheurer, Rong Wang, Audrey Bonaventure, Eleanor Kane, David R. Doody, Friederike Erdmann, Alice Y. Kang, Catherine Metayer, Elizabeth Milne, Eleni Th Petridou
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Chenan Zhang, Quinn T. Ostrom, Helen M. Hansen, Julio Gonzalez-Maya, Donglei Hu, Elad Ziv, Libby Morimoto, Adam J. de Smith, Ivo S. Muskens, Cassie N. Kline, Zalman Vaksman, Hakon Hakonarson, Sharon J. Diskin, Carol Kruchko, Jill S. Barnholtz-Sloan, Vijay Ramaswamy, Francis Ali-Osman, Melissa L. Bondy, Michael D. Taylor, Catherine Metayer, Joseph L. Wiemels, Kyle M. Walsh
Article
Endocrinology & Metabolism
Nicole C. Deziel, Yawei Zhang, Rong Wang, Joseph L. Wiemels, Libby Morimoto, Cassandra J. Clark, Catherine Metayer, Xiaomei Ma
Summary: The study revealed that Hispanic ethnicity, higher birth weight, higher maternal education, and lower birth order are associated with an increased risk of pediatric thyroid cancer, while male sex and higher birth order are associated with a decreased risk. Additional areas of investigation into biological mechanisms of this malignancy have been suggested based on the findings.
Article
Environmental Sciences
David C. Wheeler, Salem Rustom, Matthew Carli, Todd P. Whitehead, Mary H. Ward, Catherine Metayer
Summary: This study highlights the importance of evaluating multiple chemical exposures in identifying cancer risk factors. The GWQS regression method proves to be effective in estimating exposure effects for multiple chemical groups and correctly identifying important chemicals, showing favorable performance compared to other methods used in mixture analysis. The method was applied in the California Childhood Leukemia Study, revealing a positive association between exposure to the herbicide dacthal and an increased risk of childhood leukemia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Stephen S. Francis, Rong Wang, Catherine Enders, Isabel Prado, Joseph L. Wiemels, Xiaomei Ma, Catherine Metayer
Summary: The study found that lower socioeconomic status is associated with a reduced risk of childhood CNS tumors. This relationship was most consistent in astrocytomas and ependymomas, with varying findings for embryonal tumors. Further research is needed to determine specific exposures that may explain the increased risk of childhood CNS tumors associated with higher parental SES.
CANCER CAUSES & CONTROL
(2021)
Article
Neurosciences
Chenan Zhang, Quinn T. Ostrom, Eleanor C. Semmes, Vijay Ramaswamy, Helen M. Hansen, Libby Morimoto, Adam J. de Smith, Melike Pekmezci, Zalman Vaksman, Hakon Hakonarson, Sharon J. Diskin, Catherine Metayer, Michael D. Taylor, Joseph L. Wiemels, Melissa L. Bondy, Kyle M. Walsh
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Psychology, Multidisciplinary
Lyn M. Balsamo, Hannah-Rose Mitchell, Wilhelmenia Ross, Catherine Metayer, Kristina K. Hardy, Nina S. Kadan-Lottick