Article
Oncology
Duoduo Han, Yiqun Zhu, Abira A. Choudhry, Jun Cheng, Huaying Liang, Fengyu Lin, Qinyu Chang, Hong Liu, Pinhua Pan, Yan Zhang
Summary: Leukocyte telomere length is associated with an elevated risk for lung cancer, particularly for adenocarcinoma and squamous cell carcinoma, especially in never smokers.
Article
Endocrinology & Metabolism
Chenxue Bai, Zixiong Shen, Binxu Qiu, Songling Zhang
Summary: The study found that a genetically predicted longer LTL increases the risk of endometriosis, but endometriosis has no causal impact on LTL. The results strengthen the causal link between LTL and endometriosis, suggesting that LTL may serve as a potential biomarker for endometriosis, offering new possibilities for prevention and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Zhenfei Chi, Xuesong Bai, Zhe Zhang
Summary: This study used a two-sample Mendelian randomization analysis to investigate the association between aging and constipation using leukocyte telomere length (LTL) as a marker. The results showed that LTL does not necessarily indicate an increased likelihood of constipation.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Xi Zheng, Felix Wezel, Anca Azoitei, Sabine Meessen, Wenya Wang, Gregoire Najjar, Xue Wang, Johann M. Kraus, Hans A. Kestler, Axel John, Friedemann Zengerling, Christian Bolenz, Cagatay Guenes
Summary: The telomere shortening in BC and RCC patients was significantly shorter compared to patients without malignant disease. The relative telomere length in PBL cells was associated with the survival of BC and RCC patients, making it a potential prognostic marker for these cancers.
Article
Pediatrics
Joshua Garfein, Kerry S. J. Flannagan, Mercedes Mora-Plazas, Henry Oliveros, Constanza Marin, Eduardo Villamor
Summary: This study found that longer LTL among girls in middle childhood is associated with smaller increases in waist circumference, an indicator of abdominal adiposity.
Article
Biochemistry & Molecular Biology
Daniela Scarabino, Liana Veneziano, Elide Mantuano, Ivan Arisi, Alessia Fiore, Marina Frontali, Rosa Maria Corbo
Summary: Identification of potential biomarkers, such as leukocyte telomere length (LTL), is crucial for monitoring disease progression in neurodegenerative disorders like Huntington's disease. The study found that LTL reduction independently of CAG number could accurately discriminate pre-HD subjects from controls and even pre-HD from manifest HD, providing robust prognostic value in pre-HD individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Christina Raftopoulou, George Paltoglou, Evangelia Charmandari
Summary: This review summarizes the impact of childhood obesity on telomere length, revealing a negative association. Lifestyle interventions in children may lead to increased telomere length peripherally, suggesting a potential mechanistic relation worth further investigation.
Article
Immunology
Pim P. P. Edomskis, Willem A. A. Dik, Cloe L. Sparreboom, Nicole M. A. Nagtzaam, Adrie van Oudenaren, Daniel P. V. Lambrichts, Yves Bayon, Noah N. N. van Dongen, Anand G. G. Menon, Eelco J. R. de Graaf, Peter Paul L. O. Coene, Johan F. F. Lange, Pieter J. M. Leenen
Summary: This study provides detailed insights into the peripheral blood leukocyte response after colorectal cancer surgery, showing that surgery induces rapid and significant redistribution of immune cells. The phenotypic alterations in monocytes suggest a mixed profile of cellular activation and deactivation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Wu, Chenchen Yu, Nitin Shivappa, James R. Hebert, Xin Xu
Summary: The dietary inflammatory index (DII) was positively associated with renal cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) study.
Article
Oncology
Chenglei Yang, Xi Wu, Siyu Chen, Bangde Xiang
Summary: A linear causal relationship between heritable telomere length (TL) and hepatocellular carcinoma (HCC) was not observed in both Asian and European populations, according to Mendelian randomization analysis.
Article
Cell Biology
Zhu Lin, Hongmei Gao, Bing Wang, Yongqiang Wang
Summary: Previous CMV infection is associated with shorter leukocyte telomere length, independently of CRP levels.
MEDIATORS OF INFLAMMATION
(2021)
Article
Health Care Sciences & Services
LaShaunta M. Glover, Crystal W. Cene, Alexander Reiner, Samson Gebreab, David R. Williams, Kari E. North, Mario Sims
Summary: The study found that discrimination and coping with discrimination have different effects on LTL in individuals of different genders and levels of depressive symptoms. In some cases, actively coping with lifetime discrimination may help maintain longer LTL.
Article
Genetics & Heredity
Alexander V. Igoshin, Nikolay S. Yudin, Grigorii A. Romashov, Denis M. Larkin
Summary: This study used whole-genome resequencing data to estimate leukocyte telomere length and perform a genome-wide association study in 239 animals from 17 cattle breeds. Significant SNPs were identified, including ones in genes such as EXOC6B, PTPRD, and RPS6KC1. The PTPRD gene showed the strongest association and has previously been linked to leukocyte telomere length in cattle.
Article
Geriatrics & Gerontology
Sara Pudas, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Line Marie Veng-Taasti, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman
Summary: Shorter baseline LTL is associated with subsequent memory decline, but intra-individual changes in LTL may not be as informative of cognitive outcomes in aging. Long-term longitudinal evaluation of outcomes in biomarker research is essential.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniela Scarabino, Liana Veneziano, Alessia Fiore, Suran Nethisinghe, Elide Mantuano, Hector Garcia-Moreno, Gianmarco Bellucci, Nita Solanky, Maria Morello, Ginevra Zanni, Rosa Maria Corbo, Paola Giunti
Summary: SCA1, SCA2, and SCA3 have different effects on leukocyte telomere length (LTL), with SCA1 and SCA3 patients showing significant reduction in LTL and SCA2 patients showing significant increase in LTL. The relationship between LTL and age varies among the subtypes, with SCA1 patients having a significant negative relationship between LTL and age. The number of CAG repeats does not affect LTL in these SCAs. These findings suggest that LTL could serve as a potential biomarker for differentiating between SCAs and HD, but further research is needed for validation in larger cohorts and longitudinal studies.
Article
Environmental Sciences
Felicia Hung, Jonathan N. Hofmann, Pabitra R. Josse, Sarah J. Locke, Emma M. Stapleton, Gabriella Andreotti, Nicole C. Deziel, Laura E. Beane Freeman, Melissa C. Friesen
Summary: This study evaluated the validity of farmers' self-report of work activities by comparing their recall to activities observed by field staff during air monitoring. The results showed generally good agreement between the two sources, with discrepancies primarily due to activities not being observed or timing issues.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2022)
Article
Clinical Neurology
Yaqun Yuan, Srishti Shrestha, Zhehui Luo, Chenxi Li, Brenda L. Plassman, Christine G. Parks, Jonathan N. Hofmann, Laura E. Beane Freeman, Dale P. Sandler, Honglei Chen
Summary: Among farmers, high pesticide exposures may be associated with dream-enacting behaviors.
MOVEMENT DISORDERS
(2022)
Article
Environmental Sciences
C. G. Parks, K. H. Costenbader, S. Long, J. N. Hofmann, Freeman L. E. Beane, D. P. Sandler
Summary: This study investigates the association between pesticide use history and the risk of SLE and SS. The findings suggest that certain agricultural pesticides may be associated with higher or lower risk of SLE/SS, but the overall risk associated with farming appears to involve other factors and childhood exposures.
ENVIRONMENTAL RESEARCH
(2022)
Letter
Oncology
Vicky C. Chang, Ali A. Khan, Wen-Yi Huang, Hormuzd A. Katki, Mark P. Purdue, Ola Landgren, Jonathan N. Hofmann
BLOOD CANCER JOURNAL
(2022)
Article
Oncology
Marco Dicanio, Matteo Giaccherini, Alyssa Clay-Gilmour, Angelica Macauda, Juan Sainz, Mitchell J. Machiela, Malwina Rybicka-Ramos, Aaron D. Norman, Agata Tyczynska, Stephen J. Chanock, Torben Barington, Shaji K. Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E. Brown, Anna Suska, Eva K. Haastrup, Robert Z. Orlowski, Marek Dudzinski, Ramon Garcia-Sanz, Marcin Kruszewski, Joaquin Martinez-Lopez, Katia Beider, Elzbieta Iskierka-Jazdzewska, Matteo Pelosini, Sonja Berndt, Malgorzata Razny, Krzysztof Jamroziak, S. Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N. Hofmann, Mario Petrini, Aleksandra Butrym, Susan L. Slager, Elad Ziv, Edyta Subocz, Graham G. Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A. T. Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Varkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd-Sitek, Xifeng Wu, Katalin Kadar, Nicola J. Camp, Norbert Grzasko, Rosalie G. Waller, Celine Vachon, Federico Canzian, Daniele Campa
Summary: The aim of this study was to identify novel pleiotropic variants involved in multiple myeloma (MM) risk. Through analysis of 28,684 single nucleotide polymorphisms (SNPs), DNAJB4-rs34517439-A was found to be associated with an increased risk of developing MM.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Vicky C. Chang, Gabriella Andreotti, Maria Ospina, Christine G. Parks, Danping Liu, Joseph J. Shearer, Nathaniel Rothman, Debra T. Silverman, Dale P. Sandler, Antonia M. Calafat, Laura E. Beane Freeman, Jonathan N. Hofmann
Summary: This study investigated the association between glyphosate exposure and urinary oxidative stress biomarkers in farmers. The results showed that urinary glyphosate concentrations were positively associated with levels of oxidative stress biomarkers, such as 8-OHdG and MDA. The findings support the association between glyphosate exposure and oxidative stress in humans.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Public, Environmental & Occupational Health
Melissa C. Friesen, Laura Beane E. Freeman, Sarah J. Locke, Pabitra R. Josse, Shuai Xie, Susan Marie Viet, Jean-Francois Sauve, Gabriella Andreotti, Peter S. Thorne, Jonathan N. Hofmann
Summary: An algorithm was developed to estimate endotoxin exposure for farmers in the BEEA Study. It combined task intensity estimates with questionnaire responses to calculate cumulative endotoxin exposures for different tasks and time windows. The study provides insight into the variability and sources of endotoxin exposure among farmers and presents exposure estimates for future investigations.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Melissa C. Friesen, Shuai Xie, Jean-Francois Sauve, Susan Marie Viet, Pabitra R. Josse, Sarah J. Locke, Felicia Hung, Gabriella Andreotti, Peter S. Thorne, Jonathan N. Hofmann, Laura E. Beane Freeman
Summary: This study estimated endotoxin exposure for farmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) Study using published data. The task-specific endotoxin concentrations were obtained through meta-regression models. Results showed that tasks such as work in poultry and swine confinement facilities, grinding feed, veterinarian services, and cleaning grain bins had higher endotoxin concentrations, while harvesting or hauling grain and other crop-related tasks had lower concentrations.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Environmental Sciences
Darrin A. Thompson, Dana W. Kolpin, Michelle L. Hladik, Hans -Joachim Lehmler, Shannon M. Meppelink, Matthew C. Poch, John D. Vargo, Victor A. Soupene, Nafis Md Irfan, Morgan Robinson, Kurunthachalam Kannan, Laura E. Beane Freeman, Jonathan N. Hofmann, David M. Cwiertny, R. William Field
Summary: A pilot study was conducted in eastern Iowa to assess human exposure to neon-icotinoids (NEOs) among farming households. The study found that NEOs were detected in both outdoor and indoor water samples, with clothianidin being the most frequently detected NEO. Human exposure to NEOs was also found in urine samples, with multiple NEOs and metabolites being present. Additionally, the study concluded that while water consumption may contribute to exposure, other factors like diet and occupational exposure may play a bigger role.
Article
Oncology
Qianlai Luo, Jonathan N. Hofmann, Ruth M. Pfeiffer, Cari M. Kitahara, Minkyo Song, Meredith S. Shiels
Summary: Since the mid-1990s, overweight/obesity appears to have significantly contributed to the rising incidence of renal cell carcinoma (RCC) in the United States, while the contribution of non-smoking has declined. Public health interventions aimed at reducing overweight and obesity could play a crucial role in curbing this trend.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Shuai Xie, Jonathan N. Hofmann, Joshua N. Sampson, Pabitra R. Josse, Gabriella Andreotti, Jessica M. Madrigal, Mary H. Ward, Laura Beane E. Freeman, Melissa C. Friesen
Summary: This study examined the relationship between self-reported use of 2,4-D and house dust concentrations, as well as other factors, in farmers' homes. The results showed that homes with recent occupational use of 2,4-D had higher dust concentrations, and this association may be influenced by home/garden use and household characteristics.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2023)
Article
Environmental Sciences
Paul M. Bradley, Dana W. Kolpin, Darrin A. Thompson, Kristin M. Romanok, Kelly L. Smalling, Sara E. Breitmeyer, Mary C. Cardon, David M. Cwiertny, Nicola Evans, R. William Field, Michael J. Focazio, Laura E. Beane Freeman, Carrie E. Givens, James L. Gray, Gordon L. Hager, Michelle L. Hladik, Jonathan N. Hofmann, Rena R. Jones, Leslie K. Kanagy, Rachael F. Lane, R. Blaine McCleskey, Danielle Medgyesi, Elizabeth K. Medlock-Kakaley, Shannon M. Meppelink, Michael T. Meyer, Diana A. Stavreva, Mary H. Ward
Summary: Contaminant exposure in unregulated private-well tap water is a public health concern in the United States and globally. A study conducted in northeast Iowa farms found high levels of inorganics, organics, and microbial contaminants in private-well tap water. The presence of pesticides and bacteria in the water exceeds safe limits, highlighting the need for residential treatment systems and increased monitoring of rural private-well homes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Daniel E. Russ, Pabitra Josse, Thomas Remen, Jonathan N. Hofmann, Mark P. Purdue, Jack Siemiatycki, Debra T. Silverman, Yawei Zhang, Jerome Lavoue, Melissa C. Friesen
Summary: Computer-assisted coding of job descriptions to standardized occupational classification codes is important in epidemiologic studies. The study evaluated the performance of SOCcer v2, a computerized algorithm for coding free-text job descriptions to US SOC-2010 system, and found that it had a similar agreement with experts compared to previous versions. The algorithm's score can be used to prioritize jobs for expert review.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Environmental Sciences
Jongeun Rhee, Kathryn H. Barry, Wen-Yi Huang, Joshua N. Sampson, Jonathan N. Hofmann, Debra T. Silverman, Antonia M. Calafat, Julianne Cook Botelho, Kayoko Kato, Mark P. Purdue, Sonja I. Berndt
Summary: This study investigated the association between pre-diagnostic serum PFAS concentrations and aggressive prostate cancer risk. The results showed an inverse association between PFOA and aggressive prostate cancer, but this association was no longer significant for cases diagnosed more than 3 years after blood collection.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Cherrel K. Manley, Maya Spaur, Jessica M. Madrigal, Jared A. Fisher, Rena R. Jones, Christine G. Parks, Jonathan N. Hofmann, Dale P. Sandler, Laura Beane Freeman, Mary H. Ward
Summary: This study describes the drinking water sources and water quality for a large agricultural cohort, finding that agricultural communities may be exposed to elevated nitrate levels due to the proximity of their drinking water sources to farms.
ENVIRONMENTAL EPIDEMIOLOGY
(2022)
