Article
Multidisciplinary Sciences
Judith C. Hugh, Lacey S. J. Haddon, John Maringa Githaka, Gilbert Bigras, Xiuying Hu, Brittney Madden, John Hanson, Zsolt Gabos, Nadia V. Giannakopoulos, Fleur Huang, Mary M. Hitt, Kirk J. McManus, David Olson, Kelly Dabbs, John R. Mackey
Summary: Estrogen is known to promote the growth of estrogen receptor positive (ER+) breast cancers. However, hormone replacement therapy with estrogen-only has been shown to reduce the incidence and mortality of low grade, ER+, HER2- breast cancer. A clinical trial conducted on post-menopausal women showed that estradiol treatment decreased proliferation and altered gene expression in low-grade, ER+, HER2- breast cancer. The study also identified the involvement of the DREAM pathway in estrogen-induced cell cycle arrest.
Article
Nutrition & Dietetics
William S. Harris, Nathan L. Tintle, JoAnn E. Manson, Adam H. Metherel, Jennifer G. Robinson
Summary: The study investigated the effects of menopausal hormone therapy on the RBC PUFA concentrations in postmenopausal women, revealing an increase in DHA and a decrease in DPA levels after HT. This suggests that HT may stimulate the synthesis of DHA and DPA, highlighting the need for further research into the clinical implications of these changes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Edoardo Botteri, Zhiwei Xu, Nathalie C. Stoer, Gita D. Mishra
Summary: New evidence suggests a possible association between the use of menopausal hormone therapy and an increased risk of cutaneous melanoma. This study found a potential link between the use of unopposed estrogen therapy and melanoma risk, but no association was observed with estrogen-progestin therapy. Further research is needed to understand the potential impact of different types of hormone therapy on the risk of cutaneous melanoma.
Article
Public, Environmental & Occupational Health
Ako Adams Ako, Yvonne L. Michael, Lucy F. Robinson, Jean Wactawski-Wende, Aladdin H. Shadyab, Lorena Garcia, Bede N. Nriagu, Nazmus Saquib, Rami Nassir, Simin Liu, Robert B. Wallace
Summary: This study found that postmenopausal women with gallbladder disease have an increased risk of developing type 2 diabetes, especially among those with central obesity. The results support further research to determine whether interventions in older women with gallbladder disease would reduce the risk of type 2 diabetes.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Laura Lokkegaard Johansen, Mikael Thinggaard, Jesper Hallas, Merete Osler, Kaare Christensen
Summary: A study found that the preference for hormone therapy (HT) changed after the publication of the Women's Health Initiative in 2002. It was discovered that women using HT had a lower mortality rate before 2002, but after 2002 their mortality rate became similar to that of the general population. This indicates that the healthiest users decided to either discontinue HT or switch to local HT based on the changing recommendations.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Atieh Hajirahimkhan, Caitlin Howell, Elizabeth T. Bartom, Huali Dong, Daniel D. Lantvit, Xiaoling Xuei, Shao-Nong Chen, Guido F. Pauli, Judy L. Bolton, Susan E. Clare, Seema A. Khan, Birgit M. Dietz
Summary: Natural products such as hops and licorice species, particularly Glycyrrhiza inflata, have been found to have aromatase inhibitory effects and may be effective in preventing breast cancer in high-risk postmenopausal women. Liquiritigenin, a compound present in all licorice species, has potent aromatase inhibitory activity and can suppress aromatase expression in breast tissue. It also reduces the rate of cell proliferation in high-risk women, suggesting its potential for breast cancer prevention.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Michael S. Simon, Theresa A. Hastert, Ana Barac, Hailey R. Banack, Bette J. Caan, Rowan T. Chlebowski, Randi Foraker, Gayane Hovsepyan, Simin Liu, Juhua Luo, JoAnn E. Manson, Marian L. Neuhouser, Tochukwu M. Okwuosa, Kathy Pan, Lihong Qi, Julie J. Ruterbusch, Aladdin H. Shadyab, Cynthia A. Thomson, Jean Wactawski-Wende, Nida Waheed, Jennifer L. Beebe-Dimmer
Summary: This study found that cardiometabolic risk factors before cancer diagnosis were associated with greater all-cause, cardiovascular disease (CVD), cancer-specific, and other-cause mortality among postmenopausal women. Women with 3 to 4 risk factors were more likely to die compared to those with none.
Article
Oncology
Yuan Yuan, Kathy Pan, Joanne Mortimer, Rowan T. Chlebowski, Juhua Luo, Jessica E. Yan, Susan E. Yost, Candyce H. Kroenke, Lucile Adams-Campbell, Rami Nassir, Yangbo Sun, Aladdin H. Shadyab, Mara Z. Vitolins, Nazmus Saquib, Robert A. Wild, JoAnn E. Manson, Rebecca A. Nelson
Summary: In postmenopausal women with triple-negative breast cancer and 3 or 4 MetS risk components, there is a significantly higher risk of breast cancer-specific mortality and overall mortality, indicating the negative impact of metabolic risk factors on mortality outcomes.
Editorial Material
Biology
Kuldeep Singh, Rajeev Malhotra
Summary: The accumulation of iron as one grows older may hinder the positive effects of hormone replacement therapy on cardiovascular disease in women during late postmenopause.
Article
Pharmacology & Pharmacy
Dong Dong, Heng Wang, Liang Chen, Wei Wang, Tianyi Liu
Summary: This study explored the effects of 17 beta estradiol and antiestrogen treatment on the survival and functional restoration of transplanted lymph nodes. The results showed that 17 beta estradiol facilitated lymphatic reconnection and survival of transplanted lymph nodes, while antiestrogen treatment led to cellular loss and functional impairment. These findings are important for lymphatic vessel regeneration and the treatment of lymphedema.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yunguang Sun, Ning Yang, Fransiscus E. Utama, Sameer S. Udhane, Junling Zhang, Amy R. Peck, Alicia Yanac, Katherine Duffey, John F. Langenheim, Vindhya Udhane, Guanjun Xia, Jess F. Peterson, Julie M. Jorns, Marja T. Nevalainen, Romain Rouet, Peter Schofield, Daniel Christ, Christopher J. Ormandy, Anne L. Rosenberg, Inna Chervoneva, Shirng-Wern Tsaih, Michael J. Flister, Serge Y. Fuchs, Kay-Uwe Wagner, Hallgeir Rui
Summary: A humanized prolactin mouse model was developed to establish therapy-naive ER+ breast cancer tumors and study treatment resistance mechanisms, revealing new insights into precision medicine approaches for this type of cancer.
Article
Biology
Tianze Xu, Jing Cai, Lei Wang, Li Xu, Hongting Zhao, Fudi Wang, Esther G. Meyron-Holtz, Fanis Missirlis, Tong Qiao, Kuanyu Li
Summary: Postmenopausal atherosclerosis (AS) is linked to estrogen deficiency, but hormone replacement therapy (HRT) is ineffective in late postmenopausal women. This study suggests that aging-related iron accumulation inhibits the expression of estrogen receptor a (ERa), explaining the inefficacy of HRT. Iron and estradiol together downregulate ERa through Mdm2-mediated proteolysis, aggravating AS. Systemic iron chelation attenuates progressive AS in late postmenopausal mice triggered by estradiol. Immediate HRT after menopause, along with appropriate iron chelation, could provide benefits from AS.
Article
Surgery
Elizabeth L. Chou, Mary Pettinger, Bernhard Haring, Matthew A. Allison, Matthew W. Mell, Mark A. Hlatky, Jean Wactawski-Wende, Robert A. Wild, Aladdin H. Shadyab, Robert B. Wallace, Linda G. Snetselaar, Tracy E. Madsen, Matthew J. Eagleton, Mark F. Conrad, Simin Liu
Summary: This study finds that premature menopause may be an important risk factor for AAA in women with significant smoking history. There was no significant association between premature menopause and risk of AAA amongst women who have never smoked.
Article
Environmental Sciences
Angela M. Malek, Vincent C. Arena, Ruopu Song, Eric A. Whitsel, Judith R. Rager, James Stewart, Jeff D. Yanosky, Duanping Liao, Evelyn O. Talbott
Summary: This study investigated the relationship between long-term exposure to ambient particulate matter and gaseous air pollution and ALS mortality. The results showed that PM2.5 and PM10 were not significantly associated with ALS death risk, but PM10-2.5 was associated with increased risk. This study adds to the knowledge about the impact of long-term ambient pollution on ALS mortality. Further research on the relationship between air pollution and ALS is needed.
ENVIRONMENTAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Lawrence M. Nelson, Hillary Spencer, Karima Hijane, Payom Thinuan, Chaninan W. Nelson, Amanda J. Vincent, Catherine M. Gordon, Tony M. Plant, Pouneh K. Fazeli
Summary: Closing the gap between knowledge and action in healthcare is necessary. The advancement of global internet and mobile communication enables the possibility of innovative digital health education platforms and care delivery. The establishment of a global digital medical hub focused on women's health and secondary amenorrhea can improve information integration and exchange processes, benefiting patients, caregivers, providers, and researchers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Rebekah Harris, Elsa S. Strotmeyer, Leena Sharma, C. Kent Kwoh, Jennifer S. Brach, Robert Boudreau, Jane A. Cauley
Summary: This study examined how the severity of radiographic knee osteoarthritis (KOA) affects recurrent falls in middle-aged and older individuals. The results showed that older adults with radiographic evidence of KOA had a higher likelihood of experiencing recurrent falls compared to those without KOA, regardless of established risk factors. On the other hand, middle-aged adults with KOA did not have an increased odds of recurrent falls, except for those with possible KOA.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Oncology
Claire E. Thomas, Douglas C. Bauer, Jian-Min Yuan, Jane A. Cauley
Summary: This study assessed the associations between serum concentrations of cytokines and systemic immune biomarkers with the risk of prostate cancer. The results showed that the anti-inflammatory cytokine IL-10 was associated with a lower risk of prostate cancer. Further research on the relationship between IL-10, inflammation, and prostate cancer development is warranted.
CANCER CAUSES & CONTROL
(2023)
Article
Oncology
Rebecca A. Nelson, Andrew M. Blakely, Joseph C. Larson, Rowan T. Chlebowski, Yi-Jen Chen, Jane A. Cauley, Aladdin H. Shadyab, Lily L. Lai
Summary: This study followed 135,743 postmenopausal women for 17.7 years and found that postmenopausal women with pelvic cancer, especially those who received pelvic radiation, have a higher risk of pelvic fracture and overall mortality. This suggests that prevention of pelvic fractures should be emphasized in pelvic cancer survivors, in addition to cancer treatment.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Urology & Nephrology
Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie Ann Carabuena, J. Patrick Kampf, Toni Rodriguez, Aarti Sanghani, Jorge Echeverri, Paul McPherson, Michael J. Blackowicz, Julien Textoris
Summary: A study on inpatients with stage 2 or 3 AKI found a high burden of persistent severe AKI (PS-AKI) and its association with adverse clinical outcomes, with similar results for ICU and non-ICU patients. Interventions to prevent persistence of severe AKI may improve clinical outcomes for these patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Geriatrics & Gerontology
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kyle D. Moored, Yujia Susanna Qiao, Kristine Ensrud, Katie L. Stone, Kelley Pettee Gabriel, Jane A. Cauley
Summary: Increasing the frequency of active bouts and reducing the duration of sedentary bouts may lower mortality risk among older men, regardless of total sedentary time.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Economics
Nannan Li, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, Mickael Hiligsmann
Summary: This study systematically reviewed economic evaluations of interventions for osteoporosis in men and found that anti-osteoporosis drugs and nutritional supplements are cost-effective for men with osteoporosis. In addition, screening strategies and post-fracture care programs also provide economic benefits for men. The cost-effectiveness and intervention thresholds were generally similar between men and women, with slightly higher incremental cost-effectiveness ratios in men.
Article
Geriatrics & Gerontology
Sharon C. Welburn, Erin E. Fanning, Jane A. Cauley, Patrick J. Brown, Elsa S. Strotmeyer, Robert M. Boudreau, Todd M. Bear, Kyle D. Moored, Peggy M. Cawthon, Katie L. Stone, Nancy W. Glynn
Summary: This study found that both physical and mental fatigability are associated with increased fall risk in elderly men, with physical fatigability increasing the risk by 20% and mental fatigability increasing the risk of recurrent falling by 35% and 44% respectively.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Correction
Economics
Nannan Li, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, Mickael Hiligsmann
Article
Endocrinology & Metabolism
Jane A. Cauley, Howard M. Kravitz, Kristine Ruppert, Yinjuan Lian, Martica J. Hall, Sioban D. Harlow, Joel S. Finkelstein, Gail Greendale
Summary: A study found that self-reported sleep disturbances were associated with an increased risk of fractures across the menopausal transition. However, after adjusting for confounding factors, this association was largely attenuated, suggesting that shared risk factors or other factors in the causal pathway may contribute to the observed relationship.
Article
Economics
Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie A. Carabuena, J. Patrick Kampf, Paul McPherson, Toni Rodriguez, Aarti Sanghani, Julien Textoris
Summary: In hospitalized patients with COVID-19, acute kidney injury (AKI) is associated with higher mortality. This study analyzed the healthcare resource utilization (HRU) and costs related to AKI, community-acquired AKI (CA-AKI), and hospital-acquired AKI (HA-AKI). The findings showed that HA-AKI had higher excess mortality, HRU, and costs than CA-AKI, emphasizing the importance of preventing HA-AKI in COVID-19 patients.
JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kristine Ensrud, Kelley Pettee Gabriel, Deborah M. Kado, Jane A. Cauley
Summary: In addition to the volume of physical activity, frequent breaks from sedentary behavior and active bouts can reduce the risk of falls and fractures. A study found that there is a long-term relationship between the frequency of breaks from sedentary behavior and the occurrence of recurrent falls and fractures. The study also concluded that breaking up extended periods of sedentary time can reduce fall risk, regardless of the total sedentary time.
Article
Endocrinology & Metabolism
Lisa T. Langsetmo, John C. Schousboe, Brent A. Taylor, Jane A. Cauley, Howard M. Fink, Peggy M. Cawthon, Deborah E. Kado, Kristine Ensrud
Summary: Targeted fracture prevention strategies among late-life adults should consider both fracture risk and competing mortality risk. A machine learning method was used to evaluate risk factors and create models for hip fractures and competing mortality among adults aged 80 years and older. Random forest models were compared to Fine-Gray models with six variables. Top variables for predicting hip fractures were bone mineral density, while frailty was associated with competing mortality. Random forest models performed slightly better than Fine-Gray models for predicting mortality, but similarly for predicting hip fractures.
Article
Urology & Nephrology
Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie A. Carabuena, J. Patrick Kampf, Jorge Echeverri, Paul McPherson, Michael J. Blackowicz, Toni Rodriguez, Aarti R. Sanghani, Julien Textoris
Summary: This retrospective observational study compares the costs and healthcare resource utilization of patients with persistent severe acute kidney injury (PS-AKI) and patients with non-persistent severe AKI (NPS-AKI). The study finds that patients with PS-AKI have longer hospital stays and higher costs compared to those with NPS-AKI. Preventing PS-AKI may help reduce hospital stays and costs.
Article
Endocrinology & Metabolism
Joshua I. Barzilay, Petra Buzkova, Howard A. Fink, Jane A. Cauley, Laura Carbone, Rachel Elam, John A. Robbins, Phyllis Stein, Kerry Sheets, Diana Jalal, Kenneth J. Mukamal
Summary: Endothelial dysfunction, which is associated with atherosclerotic vascular disease, was not found to have a significant association with hip fracture risk in older adults based on the examination of two markers of endothelial dysfunction.
ARCHIVES OF OSTEOPOROSIS
(2023)
