Article
Oncology
Monireh Sadat Seyyedsalehi, Marta Rossi, Maryam Hadji, Hamideh Rashidian, Maryam Marzban, Maria Parpinel, Federica Fiori, Ahmad Naghibzadeh-Tahami, Yusuf A. Hannun, Chiara Luberto, Kazem Zendehdel, Paolo Boffetta
Summary: This study found that dietary betaine, choline, and choline-containing compounds are associated with the risk of colorectal cancer (CRC). Men who consume phosphocholine and sphingomyelin are more likely to develop CRC, while women who consume betaine have a decreased risk. Therefore, modifying the diet to increase betaine intake and managing the consumption of animal products can help reduce the risk of CRC.
Article
Nutrition & Dietetics
Heleen Van Puyvelde, Nikos Papadimitriou, Joanna Clasen, David Muller, Carine Biessy, Pietro Ferrari, Jytte Halkjaer, Kim Overvad, Anne Tjonneland, Renee T. Fortner, Verena Katzke, Matthias B. Schulze, Paolo Chiodini, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Marije F. Bakker, Antonio Agudo, Eva Ardanaz, Maria Dolores Chirlaque Lopez, Maria-Jose Sanchez, Ulrika Ericson, Bjorn Gylling, Therese Karlsson, Jonas Manjer, Julie A. Schmidt, Genevieve Nicolas, Corinne Casagrande, Elisabete Weiderpass, Alicia K. Heath, Lode Godderis, Koen Van Herck, Dirk De Bacquer, Marc J. Gunter, Inge Huybrechts
Summary: The study did not find strong evidence for an association between methyl-group donors involved in one-carbon metabolism and breast cancer risk. However, there was a potential U-shaped trend suggested for dietary folate intake and breast cancer risk. Further research is needed to clarify this association.
Article
Nutrition & Dietetics
Peicong Ge, Yaobo Zhao, Yuanren Zhai, Qian Zhang, Xun Ye, Jia Wang, Rong Wang, Yan Zhang, Dong Zhang, Jizong Zhao
Summary: Circulating choline and betaine are negatively associated with the risk of MMD and its subtypes.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Mahdieh Golzarand, Parvin Mirmiran, Fereidoun Azizi
Summary: The study aimed to assess the association between dietary choline and betaine intake and cardiovascular disease (CVD). The results showed that overall intake of choline and betaine was not associated with CVD risk, while higher intake of free choline was associated with a lower risk of CVD.
Article
Multidisciplinary Sciences
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y. H. Yang, Ellis Patrick
Summary: Cardiovascular disease remains a leading cause of mortality, affecting an estimated half a billion people in 2019. However, the detection of signals between specific pathophysiology and coronary plaque phenotypes using complex multi-omic discovery datasets is challenging due to individual diversity and risk factors. This study illustrates different methods for identifying subcohorts of individuals with subclinical coronary artery disease (CAD) and distinct metabolomic signatures, showing that utilizing these subcohorts can improve prediction and facilitate the discovery of novel biomarkers.
Article
Multidisciplinary Sciences
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y. . H. Yang, Ellis Patrick
Summary: Cardiovascular disease remains a leading cause of mortality, affecting an estimated half a billion people in 2019. However, detecting signals between specific pathophysiology and coronary plaque phenotypes using complex multiomic discovery datasets is challenging due to individual diversity and risk factors. Various methods, including knowledge-guided and data-driven approaches, can help identify subcohorts with distinctive metabolomic signatures and subclinical CAD, improving prediction and facilitating the discovery of new biomarkers. Analyzing cohort heterogeneity through these subcohorts can advance our understanding of CVD and provide more effective preventative treatments.
Article
Nutrition & Dietetics
Laura Diez-Ricote, Rodrigo San-Cristobal, M. Jose Concejo, Miguel a Martinez-Gonzalez, Dolores Corella, Jordi Salas-Salvado, Albert Goday, J. Alfredo Martinez, angel M. Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Jose J. Gaforio, Pilar Matia-Martin, Josep Vidal, Sebastian Mas Fontao, Emilio Ros, Zenaida Vazquez-Ruiz, Carolina Ortega-Azorin, Jesus F. Garcia-Gavilan, Mireia Malcampo, Diego Martinez-Urbistondo, Lucas Tojal-Sierra, Antonio Garcia Rodriguez, Nuria Gomez-Bellvert, Alice Chaplin, Antonio Garcia-Rios, Rosa M. Bernal-Lopez, Jose M. Santos-Lozano, Javier Basterra-Gortari, Jose Sorli, Michelle Murphy, Griselda Gasulla, Victor Mico, Itziar Salaverria-Lete, Estibaliz Goni Ochandorena, Nancy Babio, Xavier Herraiz, Jose M. Ordovas, Lidia Daimiel
Summary: This study found that increasing dietary intake of choline or betaine was associated with improvements in cardiometabolic parameters and slight improvements in markers of renal function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Shan Huang, Si Ying Lim, Sock Hwee Tan, Mark Y. Chan, Wuzhong Ni, Sam Fong Yau Li
Summary: The relationship between TMAO, betaine, and choline with acute myocardial infarction (AMI) is unclear. This study found that high betaine + low TMAO levels are associated with a significant protective effect against AMI. Furthermore, age is positively correlated with TMAO concentration, indicating a potential interplay between age and the risk of AMI associated with metabolite combination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Ting-Yu Chang, Chien-Hsien Wu, Chi-Yang Chang, Fu-Jen Lee, Bei-Wen Wang, Jia-Yau Doong, Yu-Shun Lin, Chang-Sheng Kuo, Rwei-Fen S. Huang
Summary: This case-control study found that intake of choline and betaine is associated with the development of hepatic steatosis, with low intake being linked to increased odds and high intake associated with a significant reduction in risk.
Article
Nutrition & Dietetics
Xuechen Chen, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to assess the impact of high red and processed meat intake (RPMI) on colorectal cancer (CRC) risk and compare it with genetically determined risk. The study found that RPMI increases CRC risk regardless of genetic risk. Avoiding RPMI can compensate for a substantial proportion of polygenic risk for CRC.
Article
Nutrition & Dietetics
Michaela Minarski, Christoph Maas, Christine Heinrich, Katrin A. Boeckmann, Wolfgang Bernhard, Anna Shunova, Christian F. Poets, Axel R. Franz, Steven Zeisel
Summary: Choline is essential for the development of infants, especially very low birth weight infants. However, the choline content in breast milk is lower after preterm delivery, and current formulas and fortified breast milk do not provide sufficient choline to achieve physiological concentrations. Increasing enteral choline intake is suggested to improve the growth and long-term development of very low birth weight infants.
Article
Medicine, General & Internal
Qinglin Yang, Hua Han, Zhongming Sun, Lu Liu, Xingting Zheng, Zeyu Meng, Na Tao, Jun Liu
Summary: This study systematically evaluated the role of circulating levels of choline and betaine in the risk of cardiovascular disease (CVD) and all-cause mortality. The results showed that higher levels of circulating choline were associated with a higher risk of CVD and all-cause mortality, while circulating betaine levels were not associated with the risk.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Oncology
Heleen Van Puyvelde, Niki Dimou, Aikaterini Katsikari, Blanca Iciar Indave Ruiz, Lode Godderis, Inge Huybrechts, Dirk De Bacquer
Summary: This study evaluates the associations between dietary intakes of methionine, choline, or betaine and breast cancer risk. The results did not show a clear association between dietary intake of methionine or betaine and breast cancer risk. Inconclusive evidence was found for a significant inverse association between choline intake and breast cancer risk.
CANCER EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Marta Rossi, Malak Khalifeh, Federica Fiori, Maria Parpinel, Diego Serraino, Claudio Pelucchi, Eva Negri, Attilio Giacosa, Anna Crispo, Giulia Collatuzzo, Yusuf Hannun, Chiara Luberto, Carlo La Vecchia, Paolo Boffetta
Summary: This study found an inverse association between choline intake and colorectal cancer (CRC) risk, but inconsistent findings were observed. On the other hand, sphingomyelin (SM) choline moiety was not associated with CRC risk. These results suggest that choline intake may be a favorable factor for preventing CRC.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Michela Carola Speciani, Marcello Cintolo, Mirko Marino, Maya Oren, Federica Fiori, Giorgio Gargari, Patrizia Riso, Clorinda Ciafardini, Federica Mascaretti, Maria Parpinel, Aldo Airoldi, Marcello Vangeli, Pierfrancesco Leone, Paolo Cantu, Pagona Lagiou, Cristian Del Bo, Maurizio Vecchi, Pietro Carnevali, Barbara Oreggia, Simone Guglielmetti, Rossella Bonzi, Giulia Bonato, Monica Ferraroni, Carlo La Vecchia, Roberto Penagini, Massimiliano Mutignani, Marta Rossi
Summary: The study found that the intake of anthocyanidins and flavanones is inversely associated with colorectal cancer. It also suggests that flavonoids may influence blood bacterial DNA through changes in intestinal permeability.
Letter
Dermatology
Fadwa Ahmed, Isabelle Moseley, Erica Lin, Rachel Lim, Navya Baranwal, Megan Hoang, Tiffany Libby, Oliver Wisco, Leslie Robinson-Bostom, Sameer Gupta, Abrar Qureshi, Eunyoung Cho
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Terrence M. Vance, Tricia Li, Eunyoung Cho, Aaron M. Drucker, Carlos A. Camargo, Abrar A. Qureshi
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Nutrition & Dietetics
Sang Ah Chi, Heejin Lee, Jung Eun Lee, Haeng-Shin Lee, Kyunga Kim, In-Kwon Yeo
Summary: In this study, we developed an ensemble method based on marginal-effect models (EMM) for estimating usual intake distribution. The results from simulations and real data analyses showed that EMM provided more accurate estimation compared to other methods, especially in estimating intake probability and within-person variation. EMM also demonstrated robustness in handling data with insufficient positive consumption and estimating external variance ratio with relatively low bias.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Yang Chen, Minji Kang, Hyojin Kim, Wanghong Xu, Jung Eun Lee
Summary: A study found that the Westernized dietary pattern increases the risk of obesity among Chinese adults, especially in the Southern region. There might be an inverse association between the traditional Chinese dietary pattern and obesity. This study is important for developing region-specific dietary guidelines for obesity prevention.
Letter
Dermatology
Erica M. Lin, Abrar A. Qureshi, Oliver Wisco, Eunyoung Cho
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Letter
Dermatology
Megan M. Tran, Isabelle H. Moseley, Elisabeth A. George, Abrar A. Qureshi, Eunyoung Cho
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Heejin Lee, Hyojin Kim, Sherlyn Mae P. Provido, Minji Kang, Grace H. Chung, Jae W. Lee, Sangmo Hong, Sung Hoon Yu, Chang Beom Lee, Jung Eun Lee
Summary: This study found that high dietary intake of saturated fatty acids (SFA) was significantly associated with a high prevalence of dyslipidemia in Filipino immigrant women in Korea. These results highlight the importance of dietary fat intake and the need for further research to determine risk factors for cardiovascular disease in Southeast Asian populations.
Article
Oncology
Irmina Maria Michalek, Rebecca E. Graff, Alejandro Sanchez, Toni K. Choueiri, Eunyoung Cho, Mark A. Preston, Kathryn M. Wilson
Summary: Through analyzing data from several large-scale studies, it is found that the use of statins is not significantly associated with the risk of renal cell carcinoma (RCC). However, in women, it may increase the risk of high-grade disease, and in men, using statins for more than 4 years may increase the risk of clear cell RCC.
Article
Dermatology
M. Sachar, B. M. Lin, V. Wong, W. Li, V. Huang, J. Harris, K. Ezzedine, E. Cho, A. A. Qureshi
Summary: Regular use of acetaminophen may increase the risk of vitiligo in women.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Erica M. Lin, Rachel K. Lim, Shirley Lin, Eunyoung Cho
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hee Sun Kim, Heejin Lee, Sherlyn Mae P. Provido, Grace H. Chung, Sangmo Hong, Sung Hoon Yu, Jung Eun Lee, Chang Beom Lee
Summary: The study on the association between sleep duration and metabolic disorders in Filipino immigrants in Korea showed a significant linear relationship between increased sleep duration and elevated triglycerides, total cholesterol, and LDL-C levels.
JOURNAL OF OBESITY & METABOLIC SYNDROME
(2023)
Article
Nutrition & Dietetics
Hyun Jeong Cho, Akinkunmi Paul Okekunle, Ga-Eun Yie, Jiyoung Youn, Moonil Kang, Taiyue Jin, Joohon Sung, Jung Eun Lee
Summary: This study used Mendelian randomization to test the causal association between genetically predicted coffee consumption and type 2 diabetes. The results showed that genetically predicted increased coffee consumption was associated with a reduced prevalence of type 2 diabetes. In addition, genetically predicted coffee consumption was also associated with lower levels of fasting blood glucose and 2-hour postprandial glucose.
NUTRITION RESEARCH AND PRACTICE
(2023)
Review
Biology
Marcelo Paiva, Sara Yumeen, Benjamin J. Kahn, Hongmei Nan, Eunyoung Cho, Elie Saliba, Abrar Qureshi
Summary: Climate change and environmental health have an impact on agriculture and food supply, which ultimately affects population health. Research suggests that dietary nutrients, particularly those found in commonly consumed beverages, may influence the risk for skin cancer. Citrus juices and white wine may be associated with increased risk for skin cancer, while caffeinated beverages like coffee, tea, and cola may be associated with decreased risk for certain types of skin cancer.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2023)
Article
Dermatology
Isabelle H. Moseley, Elisabeth A. George, Megan M. Tran, Hemin Lee, Abrar A. Qureshi, Eunyoung Cho
Summary: This study estimated the prevalence of alopecia areata (AA) in different racial/ethnic and socio-economic groups. It found that individuals with skin of color had a higher prevalence of AA, while those with lower education and income levels and no health insurance had a lower prevalence.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Isabelle H. Moseley, Jordan M. Thompson, Elisabeth A. George, Sara D. Ragi, Jae H. Kang, Anthony M. Reginato, Abrar Qureshi, Eunyoung Cho
Summary: This prospective study found that personal history of immune-mediated diseases is associated with an increased risk of alopecia areata (AA).
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
