Article
Medicine, General & Internal
Youjie Zeng, Si Cao, Heng Yang
Summary: This study used Mendelian randomization analysis to find that circulating SHBG levels attenuated the risk of small vessel stroke, possibly mediated by lowering glycated hemoglobin levels. Further analysis suggests that insulin-like growth factor/insulin-like growth factor binding proteins may be involved in this process. However, there was no causal association found between SHBG and large vessel stroke or cardioembolic stroke.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Yelda A. Leal, Minkyo Song, Jovanny Zabaleta, Gilberto Medina-Escobedo, Patrick Caron, Aurelio Lopez-Colombo, Chantal Guillemette, M. Constanza Camargo
Summary: The study suggests that higher levels of circulating DHEA may be associated with a lower risk of noncardia gastric cancer, while estradiol and testosterone levels were not significantly linked to gastric cancer. Further longitudinal studies are needed to explore the temporality of this association and the mechanisms of disease pathogenesis.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Oche Adam Itodo, Peter Francis Raguindin, Jens Wollner, Inge Eriks-Hoogland, Xavier Jordan, Margret Hund-Georgiadis, Taulant Muka, Jurgen Pannek, Jivko Stoyanov, Marija Glisic
Summary: This study investigated longitudinal changes in androgen levels in individuals with SCI during initial inpatient rehabilitation stay and found a significant increase in total testosterone and DHEA-S in men with SCI, suggesting the need for further research on the impact of these hormonal changes on neurological recovery and metabolic parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen, Sophia Harlid
Summary: Endogenous sex hormones and DNA methylation have important roles in various diseases, but their interaction is largely unknown. This study investigated the associations between circulating sex hormones, sex hormone binding globulin (SHBG), and DNA methylation in blood samples from 77 men. The findings suggest a relationship between circulating sex hormones and DNA methylation, and several differentially methylated regions were associated with hormone-related genes and diseases.
Article
Public, Environmental & Occupational Health
Shuai Yuan, Lijuan Wang, Jing Sun, Lili Yu, Xuan Zhou, Jie Yang, Yimin Zhu, Dipender Gill, Stephen Burgess, Joshua C. Denny, Susanna C. Larsson, Evropi Theodoratou, Xue Li
Summary: This study used Mendelian randomization to investigate the associations between sex hormone binding globulin (SHBG), testosterone, and estradiol levels and disease outcomes. The results suggest a causal relationship between sex hormones and several health outcomes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
E. Aribas, F. Ahmadizar, U. Mutlu, M. K. Ikram, D. Bos, J. S. E. Laven, C. C. W. Klaver, M. A. Ikram, J. L. Roeters van Lennep, M. Kavousi
Summary: The study found that a more androgenic profile was associated with more microvascular damage in both women and men. However, among women, higher androgen levels were also associated with less macrovascular damage.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ali Alquraini
Summary: This study evaluated the efficacy of hexaconazole to bind with sex hormone-binding globulin (SHBG) and found that it has a stable molecular interaction with SHBG, leading to significant endocrine disruption during agricultural work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Michel E. S. Watz, Asa Tivesten, Kristin Ottarsdottir, Ying Li, Margareta I. Hellgren, Ulf Lindblad, Bledar Daka
Summary: The study investigated the association between SHBG levels, blood pressure changes, and development of hypertension. The results showed that higher SHBG levels were associated with a lower risk of developing hypertension and a decrease in blood pressure levels.
JOURNAL OF HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Pei Xu, Rong Zeng, Qiyou Wan, Yan Xie, Xingyan Liu, Songlin An, Jing Jiang, Jing Yang, Yuanzhong Zhou, Xubo Shen
Summary: This study investigated the association between serum sex hormone-binding globulin (SHBG) levels and synthesis-related factors in men of different age groups. The findings revealed that SHBG levels increased with age while the levels of hepatic nuclear factor 4α (HNF-4α) and peroxisome proliferator-activated receptor γ (PPAR-γ) decreased. Similar results were observed in rats, suggesting that the aging-related increase in SHBG levels is associated with increased SHBG synthesis.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Yutang Wang
Summary: This study established criteria for low SHBG among US adults and found the estimated national prevalence to be 3.3% in men and 2.7% in women. Risk factors for this condition include higher BMI, diabetes, ethnicity, COPD, coronary heart disease, and smoking.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Neurosciences
Kevin M. Hellman, Folabomi A. Oladosu, Ellen F. Garrison, Genevieve E. Roth, Katlyn E. Dillane, Frank F. Tu
Summary: Elevated levels of estradiol were found in women with dysmenorrhea and bladder sensitivity, while sex hormone-binding globulin levels were higher in women with bladder pain syndrome. These hormonal differences may be related to distinct pain sensitivity mechanisms.
Article
Nutrition & Dietetics
Yutang Wang
Summary: Consumption of tree nuts is positively associated with circulating levels of SHBG in women in a general population, particularly in premenopausal women. Adjustment for all tested confounders showed that tree nut consumption is positively associated with SHBG levels, but not with testosterone and estradiol.
NUTRITION RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Rob Molenberg, Chris H. L. Thio, Marlien W. Aalbers, Maarten Uyttenboogaart, Susanna C. Larsson, Mark K. Bakker, Ynte M. Ruigrok, Harold Snieder, J. Marc C. van Dijk
Summary: Using a 2-sample MR study, we found that genetic predisposition to elevated SHBG levels, with secondary lower BioT levels, is associated with an increased risk of aSAH in women.
Article
Behavioral Sciences
Orly Kerub, Eric J. Haas, Gal Meiri, Natalya Bilenko, Hagit Flusser, Analya Michaelovski, Ilan Dinstein, Nadav Davidovitch, Idan Menashe
Summary: The prevalence of autism spectrum disorder (ASD) is continuously rising worldwide, with significant differences in ASD rates among different ethnic and socioeconomic groups. A study comparing Bedouin and Jewish toddlers in southern Israel found that while both groups were equally identified in the ASD screening, Bedouin toddlers were less likely to complete the diagnosis process due to higher loss-to-follow-up rates and slower diagnosis process. Facilitating ASD diagnosis for the Bedouin population will help identify more toddlers with ASD.
Article
Gastroenterology & Hepatology
Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R. Abecasis, Demetrius Albanes, Sonja Berndt, Stephane Bezieau, D. Timothy Bishop, Hermann Brenner, Stephan Buch, Andrea Burnett-Hartman, Peter T. Campbell, Sergi Castellvi-Bel, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Sang Hee Cho, David Conti, Albert de la Chapelle, Edith J. M. Feskens, Steven J. Gallinger, Graham G. Giles, Phyllis J. Goodman, Andrea Gsur, Mark Guinter, Marc J. Gunter, Jochen Hampe, Heather Hampel, Richard B. Hayes, Michael Hoffmeister, Ellen Kampman, Hyun Min Kang, Temitope O. Keku, Hyeong Rok Kim, Loic Le Marchand, Soo Chin Lee, Christopher Li, Li Li, Annika Lindblom, Noralane Lindor, Roger L. Milne, Victor Moreno, Neil Murphy, Polly A. Newcomb, Deborah A. Nickerson, Kenneth Offit, Rachel Pearlman, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Lori C. Sakoda, Clemens Schafmayer, Stephanie L. Schmit, Robert E. Schoen, Fredrick R. Schumacher, Martha L. Slattery, Yu-Ru Su, Catherine M. Tangen, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Xiaoliang Wang, Emily White, Alicja Wolk, Michael O. Woods, Graham Casey, Li Hsu, Mark A. Jenkins, Stephen B. Gruber, Ulrike Peters, Wei Zheng
Summary: This study identified multiple genes associated with colorectal cancer risk through a transcriptome-wide association study, including genes in novel loci. Furthermore, previously unreported genes were also discovered in known GWAS-identified loci. Through colocalization analysis, additional putative susceptibility genes were identified, providing new insights into the biological mechanisms underlying CRC development.
Article
Psychology, Developmental
Ohad Regev, Gal Cohen, Amnon Hadar, Jenny Schuster, Hagit Flusser, Analya Michaelovski, Gal Meiri, Ilan Dinstein, Reli Hershkovitch, Idan Menashe
Summary: The study found evidence of abnormal head growth in children with autism spectrum disorder (ASD) during the prenatal period, particularly in the second trimester. Male fetuses had larger heads than females, and fetal head growth was slower in ASD and TDS groups compared to TDP. Sex had an impact on fetal head growth and its association with the severity of ASD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Letter
Genetics & Heredity
Minta Thomas, Lori C. Sakoda, Michael Hoffmeister, Elisabeth A. Rosenthal, Jeffrey K. Lee, Franzel J. B. van Duijnhoven, Elizabeth A. Platz, Anna H. Wu, Christopher H. Dampier, Albert de la Chapelle, Alicja Wolk, Amit D. Joshi, Andrea Burnett-Hartman, Andrea Gsur, Annika Lindblom, Antoni Castells, Aung Kowin, Bahram Namjou, Bethany Van Guelpen, Catherine M. Tangen, Qianchuan He, Christopher I. Li, Clemens Schafmayer, Corinne E. Joshu, Cornelia M. Ulrich, D. Timothy Bishop, Daniel D. Buchanan, Daniel Schaid, David A. Drew, David C. Muller, David Duggan, David R. Crosslin, Demetrius Albanes, Edward L. Giovannucci, Eric Larson, Flora Qu, Frank Mentch, Graham G. Giles, Hakon Hakonarson, Heather Hampel, Ian B. Stanaway, Jane C. Figueiredo, Jeroen R. Huyghe, Jessica Minnier, Jenny Chang-Claude, Jochen Hampe, John B. Harley, Kala Visvanathan, Keith R. Curtis, Kenneth Offit, Li Li, Loic Le Marchand, Ludmila Vodickova, Marc J. Gunter, Mark A. Jenkins, Martha L. Slattery, Mathieu Lemire, Michael O. Woods, Mingyang Song, Neil Murphy, Noralane M. Lindor, Ozan Dikilitas, Paul D. P. Pharoah, Peter T. Campbell, Polly A. Newcomb, Roger L. Milne, Robert J. MacInnis, Sergi Castellvi-Bel, Shuji Ogino, Sonja I. Berndt, Stephane Bezieau, Stephen N. Thibodeau, Steven J. Gallinger, Syed H. Zaidi, Tabitha A. Harrison, Temitope O. Keku, Thomas J. Hudson, Veronika Vymetalkova, Victor Moreno, Vicente Martin, Volker Arndt, Wei-Qi Wei, Wendy Chung, Yu-Ru Su, Richard B. Hayes, Emily White, Pavel Vodicka, Graham Casey, Stephen B. Gruber, Robert E. Schoen, Andrew T. Chan, John D. Potter, Hermann Brenner, Gail P. Jarvik, Douglas A. Corley, Ulrike Peters, Li Hsu
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Environmental Sciences
Danielle N. Medgyesi, Jared A. Fisher, Abigail R. Flory, Richard B. Hayes, George D. Thurston, Linda M. Liao, Mary H. Ward, Debra T. Silverman, Rena R. Jones
Summary: The study evaluated the performance of a commercial database in finding residences and estimating environmental exposures. Results showed that time period and population characteristics influenced the attainment of addresses, but accuracy and subsequent estimation of specific air pollution exposures were high in the older study population.
ENVIRONMENTAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jeroen R. Huyghe, Tabitha A. Harrison, Stephanie A. Bien, Heather Hampel, Jane C. Figueiredo, Stephanie L. Schmit, David Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A. Baron, Amanda J. Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M. Levine, Vittorio Perduca, Aurora Perez-Cornago, Lori C. Sakoda, Fredrick R. Schumacher, Martha L. Slattery, Amanda E. Toland, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Antonio Agudo, Demetrius Albanes, M. Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Barbara L. Banbury, Michael C. Bassik, Sonja Berndt, Stephane Bezieau, D. Timothy Bishop, Juergen Boehm, Heiner Boeing, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D. Buchanan, Andrea Burnett-Hartman, Bette J. Caan, Peter T. Campbell, Prudence R. Carr, Antoni Castells, Sergi Castellvi-Bel, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Keith R. Curtis, Albert de la Chapelle, Douglas F. Easton, Dallas R. English, Edith J. M. Feskens, Manish Gala, Steven J. Gallinger, W. James Gauderman, Graham G. Giles, Phyllis J. Goodman, William M. Grady, John S. Grove, Andrea Gsur, Marc J. Gunter, Robert W. Haile, Jochen Hampe, Michael Hoffmeister, John L. Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J. Hudson, Mazda Jenab, Mark A. Jenkins, Amit D. Joshi, Temitope O. Keku, Charles Kooperberg, Tilman Kuhn, Sebastien Kury, Loic Le Marchand, Flavio Lejbkowicz, Christopher Li, Li Li, Wolfgang Lieb, Annika Lindblom, Noralane M. Lindor, Satu Mannisto, Sanford D. Markowitz, Roger L. Milne, Lorena Moreno, Neil Murphy, Rami Nassir, Kenneth Offit, Shuji Ogino, Salvatore Panico, Patrick S. Parfrey, Rachel Pearlman, Paul D. P. Pharoah, Amanda Phipps, Elizabeth A. Platz, John D. Potter, Ross L. Prentice, Lihong Qi, Leon Raskin, Gad Rennert, Hedy S. Rennert, Elio Riboli, Clemens Schafmayer, Robert E. Schoen, Daniela Seminara, Mingyang Song, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Antonia Trichopoulou, Cornelia M. Ulrich, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Goncalo R. Abecasis, Deborah A. Nickerson, Peter C. Scacheri, Anshul Kundaje, Graham Casey, Stephen B. Gruber, Li Hsu, Victor Moreno, Richard B. Hayes, Polly A. Newcomb, Ulrike Peters
Summary: Understanding the etiologic heterogeneity of colorectal cancer is crucial for precision prevention efforts. By performing GWAS meta-analyses, we identified 13 loci that reached genome-wide significance for specific colorectal cancer subsites, with evidence of heterogeneity between anatomical subsites. This suggests that the genetic architectures of proximal and distal CRC are partly distinct, highlighting the importance of considering tumour subsite in studies of risk factors and prevention strategies.
Article
Oncology
Ajay Prakash, Brandilyn A. Peters, Emilia Cobbs, Dia Beggs, Heesun Choi, Huilin Li, Richard B. Hayes, Jiyoung Ahn
Summary: The study found that smoking significantly alters the composition of the fecal microbiome, different from never smokers. Enriched and depleted taxa in smokers are consistent across different populations. Additionally, taxa enriched in smokers are positively correlated with the inferred abundance of pathways related to smoking-associated toxin breakdown and response to reactive oxygen species (ROS).
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Brittny C. Davis Lynn, Pavel Chernyavskiy, Gretchen L. Gierach, Philip S. Rosenberg
Summary: The incidence of ER-negative breast cancer has decreased from 1992 to 2016 in all age groups and racial or ethnic groups. The greatest decrease was observed in Hispanic White women aged 40-49 years.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Editorial Material
Oncology
Richard B. Hayes
Summary: In recent decades, there has been a significant increase in the incidence of early-onset colorectal cancer in the US and internationally, particularly among individuals born in the 1960s and after. While research on the reasons for this trend is still ongoing, sporadic disease and obesity are potentially important factors contributing to the rise of early-onset colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Environmental Sciences
Sabah M. Quraishi, Marnie F. Hazlehurst, Christine T. Loftus, Ruby H. N. Nguyen, Emily S. Barrett, Joel D. Kaufman, Nicole R. Bush, Catherine J. Karr, Kaja Z. LeWinn, Sheela Sathyanarayana, Frances A. Tylavsky, Adam A. Szpiro, Daniel A. Enquobahrie
Summary: This study investigated the impact of prenatal exposure to air pollution, specifically fine particulate matter (PM2.5), on birth outcomes. The findings suggest a significant association between PM2.5 exposure and lower birthweight, with stronger effects observed in male infants and those from lower income households.
ENVIRONMENTAL RESEARCH
(2022)
Article
Oncology
Catherine M. Olsen, Nirmala Pandeya, Philip S. Rosenberg, David C. Whiteman
Summary: The incidence rate of in situ melanomas, which are asymptomatic tumors, has been increasing over the past few decades. Compared to previous eras, a higher number of in situ melanomas are now being detected, with patients tending to be older on average.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Caroline Y. Um, Brandilyn A. Peters, Hee Sun Choi, Paul Oberstein, Dia B. Beggs, Mykhaylo Usyk, Feng Wu, Richard B. Hayes, Susan M. Gapstur, Marjorie L. McCullough, Jiyoung Ahn
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Kelsey R. Monson, Brandilyn A. Peters, Mykhaylo Usyk, Caroline Y. Um, Paul E. Oberstein, Marjorie L. McCullough, Mark P. Purdue, Neal D. Freedman, Richard B. Hayes, Jiyoung Ahn
Summary: This study demonstrates that diets high in carbohydrates and glycemic index (GI) may influence the composition of the oral microbiome, with high carbohydrate intake associated with certain carcinogenic bacteria and decreased abundance of protective bacteria, and high GI intake associated with increased abundance of certain inflammation-related bacteria.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Alexi N. Archambault, Yi Lin, Jihyoun Jeon, Tabitha A. Harrison, D. Timothy Bishop, Hermann Brenner, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Jane C. Figueiredo, Steven Gallinger, Stephen B. Gruber, Marc J. Gunter, Michael Hoffmeister, Mark A. Jenkins, Temitope O. Keku, Loic Le Marchand, Li Li, Victor Moreno, Polly A. Newcomb, Rish Pai, Patrick S. Parfrey, Gad Rennert, Lori C. Sakoda, Robert S. Sandler, Martha L. Slattery, Mingyang Song, Aung Ko Win, Michael O. Woods, Neil Murphy, Peter T. Campbell, Yu-Ru Su, Anne Zeleniuch-Jacquotte, Peter S. Liang, Mengmeng Du, Li Hsu, Ulrike Peters, Richard B. Hayes
Summary: In this large study, several nongenetic risk factors associated with early-onset colorectal cancer were identified, providing a basis for targeted identification of high-risk individuals, which is crucial in mitigating the increasing burden of this disease.
JNCI CANCER SPECTRUM
(2021)
Article
Psychology, Developmental
Yonah Hendel, Gal Meiri, Hagit Flusser, Analya Michaelovski, Ilan Dinstein, Idan Menashe
Summary: Research indicates that despite government funding for post-diagnostic genetic testing for children with ASD in Israel, only a third of families completed the testing. Doctor's recommendation was the main factor influencing compliance, with over 50% of non-compliant families considering genetic testing irrelevant. This highlights the importance of clear recommendations and explanations to emphasize the benefits and relevance of genetic testing for children with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)