Review
Chemistry, Medicinal
Stephen T. Sonis
Summary: Toxicities associated with radiation therapy can be effectively mitigated through interventions aimed at disrupting the biological cascade of toxicity development, with oxidative stress being a key initiator of normal tissue injury. Attempts to supplement endogenous superoxide dismutases or develop synthetic dismutase mimetics have shown some potential, with avasopasem manganese emerging as a promising dismutase mimetic in clinical trials for reducing severe oral mucositis in head and neck cancer patients undergoing chemoradiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Chia-Chu Liu, Chia-Fang Wu, Yung-Chin Lee, Tsung-Yi Huang, Shih-Ting Huang, Hsun-Shuan Wang, Jhen-Hao Jhan, Shu-Pin Huang, Ching-Chia Li, Yung-Shun Juan, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chu-Chih Chen, Ming-Tsang Wu
Summary: Environmental exposure to melamine increases the risk of oxidative stress and early kidney injury. The single-nucleotide polymorphisms (SNPs) of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in patients with calcium urolithiasis.
Article
Biochemistry & Molecular Biology
Matic Broz, Veronika Furlan, Samo Lesnik, Marko Jukic, Urban Bren
Summary: A mutation in the MnSOD gene (rs4880, Ala16Val) has been linked to various types of cancer and autoimmune diseases. This study shows that this mutation disrupts the secondary structure of MnSOD and reduces its activity.
Article
Medicine, Research & Experimental
Francis Jackson de Oliveira Paludo, Matheus Augusto de Bittencourt Pasquali, Amanda Rodrigues de Vargas, Iara Bezerra de Oliveira, Luzia Valberligia Batista Goncalves, Daniel Pens Gelain, Jose Claudio Fonseca Moreira
Summary: This study focused on the impact of SOD2 polymorphism on sperm motility and vigor, finding that the Val16Ala polymorphism could alter the activity of superoxide dismutase in sperm, affecting sperm physiology and postfertilization processes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Review
Biochemistry & Molecular Biology
Xu Zhang, Depei Zhang, Li Xiang, Qiying Wang
Summary: Manganese superoxide dismutase exhibits rapid product inhibition at high temperatures but is less inhibited at lower temperatures. The temperature-dependent kinetics can be explained by changes in coordination of manganese superoxide dismutase. Cold activation of the enzyme is an adaptive response to low temperatures and plays a role in cold stress signaling and physiological responses.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Bing Chen, Hao-Qiang Shi, Meihua Rose Feng, Xi-Han Wang, Xiao-Mei Cao, Wei-Min Cai
Summary: This study established a population pharmacokinetic model for INH and AcINH in Chinese population, evaluating the impact of NAT2 genotype on drug transformation and metabolism, which may be beneficial for individualized therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Li-Qiang Wang, Yeyang Ma, Han-Ye Yuan, Kun Zhao, Mu-Ya Zhang, Qiang Wang, Xi Huang, Wen-Chang Xu, Bin Dai, Jie Chen, Dan Li, Delin Zhang, Zhengzhi Wang, Liangyu Zou, Ping Yin, Cong Liu, Yi Liang
Summary: The authors determined the cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 during the pathogenesis of ALS.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Bing Chen, Hao-Qiang Shi, Meihua Rose Feng, Xi-Han Wang, Xiao-Mei Cao, Wei-Min Cai
Summary: This study aimed to establish a population pharmacokinetic model for isoniazid (INH) and its major metabolite Acetylisoniazid (AcINH) in Chinese participants and tuberculosis patients, and to assess the role of the NAT2 genotype on the transformation of INH to AcINH. The study also estimated the INH exposure required to achieve 90% effective concentration (EC90) in patients with different NAT2 genotypes. The results showed that NAT2 genotypes had different effects on the metabolism of INH and AcINH, and the probability of target attainment of INH EC90 varied among patients with different NAT2 genotypes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Ismiana Pajatiwi, Rahmat Muliadi, Ratna A. Utami, Anita Artarini, Wangsa T. Ismaya
Summary: The manganese superoxide dismutase from Staphylococcus equorum (MnSODSeq) has shown robust activity under various conditions. Strengthening the interactions between the monomers is crucial for improving the enzyme stability. A new strategy using K38R-A121E/Y double substitutions has been proposed, resulting in mutants with similar enzyme activity and enhanced thermal stability. The structure of the L169W mutant was also elucidated, revealing the impact of intramolecular modification on enzyme stability.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Kavya Gauba, Shruti Gupta, Jyoti Shekhawat, Naveen Dutt, Dharmveer Yadav, Vijaya Lakshmi Nag, Mahadev Rao, Praveen Sharma, Mithu Banerjee
Summary: This study aimed to investigate the association between MnSOD gene polymorphism and enzyme levels and mRNA expression in TB patients. The serum SOD2 levels and gene polymorphism were measured in 87 TB patients and 85 healthy individuals. The results showed that the TB patients had lower serum SOD2 levels and mRNA expression compared to the healthy subjects, but there was no significant difference in enzyme levels and mRNA expression among different genotypes.
MICROBES AND INFECTION
(2023)
Article
Oncology
Merce Juliachs, Mireia Pujals, Chiara Bellio, Nathalie Meo-Evoli, Juan M. Duran, Esther Zamora, Mireia Pares, Anna Sunol, Olga Mendez, Alex Sanchez-Pla, Francesc Canals, Cristina Saura, Josep Villanueva
Summary: This study aims to find circulating biomarkers for monitoring the response to cancer therapy. The research found that the release of SOD2 protein during chemotherapy treatment is associated with tumor cell death, and the increase in its circulating levels correlates with treatment response, which can be used for non-invasive monitoring of breast cancer patients.
Article
Biochemistry & Molecular Biology
Lara Rouco, Rebeca Alvarino, Amparo Alfonso, Maria J. Romero, Rosa Pedrido, Marcelino Maneiro
Summary: This study investigates the antioxidant properties of four manganese(II) complexes with fluorescent dyes and their protective effects on SH-SY5Y neuroblastoma cells. The complexes showed significant antioxidant activity and improved cell survival by reducing reactive oxygen species release. The incorporation of the fluorescent label allowed the study of their cellular uptake in the neuroblastoma cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Letter
Dermatology
Jin Dai, Tricia Y. Li, Eunyoung Cho, Abrar A. Qureshi, Wen-Qing Li
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Wen-Hui Wu, Hao Geng, Eunyoung Cho, A. Heather Eliassen, Aaron M. Drucker, Tricia Y. Li, Abrar A. Qureshi, Wen-Qing Li
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Hsuan Yen, Hsi Yen, Aaron M. Drucker, Jiali Han, Wen-Qing Li, Tricia Li, Abrar Qureshi, Eunyoung Cho
Summary: Some clinical trials have found that the use of cyclooxygenase-2 (COX-2) inhibitors may lower the risk of skin cancer in high-risk groups. However, this study suggests that the use of COX-2 inhibitors is associated with a slightly increased risk of basal cell carcinoma (BCC) but not statistically significant for cutaneous squamous cell carcinoma (cSCC) and melanoma.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kanglian Zheng, Xu Zhu, Shijie Fu, Guang Cao, Wen-Qing Li, Liang Xu, Hui Chen, Di Wu, Renjie Yang, Kun Wang, Wei Liu, Hongwei Wang, Quan Bao, Ming Liu, Chunyi Hao, Lin Shen, Baocai Xing, Xiaodong Wang
Summary: This study compared the efficacy and safety of sorafenib plus 3cir-OFF hepatic arterial infusion chemotherapy (HAIC) with sorafenib alone for advanced hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT). The results showed that sorafenib plus HAIC achieved better overall survival (OS) and longer progression-free survival (PFS) compared to sorafenib alone, but also had more adverse events.
Article
Cardiac & Cardiovascular Systems
Pengcheng Huai, Jian Liu, Xing Ye, Wen-Qing Li
Summary: The study aimed to explore the association between central obesity and mortality. The results showed that central obesity was significantly associated with increased risk of all-cause and cardiovascular diseases-related mortality, even among normal weight adults.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xue Li, Kaifeng Pan, Michael Vieth, Markus Gerhard, Wenqing Li, Raquel Mejias-Luque
Summary: Helicobacter pylori infection activates the JAK-STAT signaling pathway and upregulates PD-L1 expression, leading to immune suppression and contributing to the development and progression of gastric cancer. The activation of STAT1 and upregulation of PD-L1 are associated with premalignant lesions, immune infiltration, and poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wenhui Wu, Zongchao Liu, Zhexuan Li, Weidong Liu, Lanfu Zhang, Yang Zhang, Tong Zhou, Weicheng You, Kaifeng Pan, Wenqing Li
Summary: This study aimed to investigate the alterations in metabolomic profiles caused by treatment of H. pylori infection and their associations with the risk of gastric lesion progression. The results showed that treatment of H. pylori infection significantly altered plasma metabolic profiles in the short term and key metabolites could distinguish participants with successful eradication from those with failed eradication. However, these metabolites might not substantially affect metabolic regulation in the long term.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Medicine, Research & Experimental
Zong-Chao Liu, Wen-Hui Wu, Sha Huang, Zhong-Wu Li, Xue Li, Guang-Hou Shui, Sin Man Lam, Bo-Wen Li, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li
Summary: This study identified lipidomic signatures associated with the risk of gastric lesion progression and gastric cancer occurrence, with translational implications for gastric cancer prevention.