Article
Oncology
Nur Zeinomar, Amelia Grant-Alfieri, Kimberly R. Burke, Milagros de Hoz, Parisa Tehranifar, Desiree A. H. Walker, Taylor Morton, Peggy Shepard, Julie B. Herbstman, Rachel L. Miller, Frederica Perera, Mary Beth Terry
Summary: Growing evidence shows that exposures during adolescence can increase cancer risk later in life, especially for common cancers like breast cancer. An educational tool focused on modifying cancer risk factors was developed for adolescents, with an emphasis on addressing structural barriers and promoting environmental justice. The tool included a module covering cancer biology, local cancer burden, and risk reduction strategies, and was administered to over 280 high school and college students in New York City. Students identified various strategies for reducing cancer risk at both individual and community levels, suggesting the tool's potential for adoption in other communities and educational institutions.
JOURNAL OF CANCER EDUCATION
(2022)
Article
Health Policy & Services
Grace C. Hillyer, Meaghan Nazareth, Sarah Lima, Karen M. Schmitt, Andria Reyes, Elaine Fleck, Gary K. Schwartz, Mary Beth Terry
Summary: E-cigarette use is more prevalent among young adults, current smokers, frequent binge drinkers, and households with smokers. Binge alcohol consumption and tobacco smoking are associated with increased risk of cancer.
JOURNAL OF COMMUNITY HEALTH
(2022)
Article
Oncology
Teofilia Acheampong, Erica J. Lee Argov, Mary Beth Terry, Carmen B. Rodriguez, Mariangela Agovino, Ying Wei, Shweta Alithat, Parisa Tehranifar
Summary: This study investigated the relationship between regular aspirin use and MBD and found a positive association with non-dense area, particularly among women with higher BMI.
CANCER CAUSES & CONTROL
(2022)
Article
Oncology
Nicole M. Niehoff, Mary Beth Terry, Deborah B. Bookwalter, Joel D. Kaufman, Katie M. O'Brien, Dale P. Sandler, Alexandra J. White
Summary: This study suggests that there is an association between NO2 exposure and increased breast cancer risk in women with higher familial risk, while the association with PM2.5 did not vary. The impact of different pollutants on breast cancer risk may vary among individuals with different levels of familial risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Zhoufeng Ye, Shuai Li, Gillian S. Dite, Tuong L. Nguyen, Robert J. MacInnis, Irene L. Andrulis, Saundra S. Buys, Mary B. Daly, Esther M. John, Allison W. Kurian, Jeanine M. Genkinger, Wendy K. Chung, Kelly-Anne Phillips, Heather Thorne, Ingrid M. Winship, Roger L. Milne, Pierre-Antoine Dugue, Melissa C. Southey, Graham G. Giles, Mary Beth Terry, John L. Hopper
Summary: This study investigates the predictive power of weight and body mass index (BMI) for breast cancer risk, finding that weight is more informative than BMI. The association between weight and breast cancer risk appears to be relevant for both adipose and nonadipose tissue, and is independent but multiplicative with underlying familial risk.
CANCER PREVENTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eileen O. Dareng, Jonathan P. Tyrer, Daniel R. Barnes, Michelle R. Jones, Xin Yang, Katja K. H. Aben, Muriel A. Adank, Simona Agata, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Gerasimos Aravantinos, Banu K. Arun, Annelie Augustinsson, Judith Balmana, Elisa Bandera, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Marcus Q. Bernardini, Line Bjorge, Amanda Black, Natalia Bogdanova, Bernardo Bonanni, Ake Borg, James D. Brenton, Agnieszka Budzilowska, Ralf Butzow, Saundra S. Buys, Hui Cai, Maria A. Caligo, Ian Campbell, Rikki Cannioto, Hayley Cassingham, Jenny Chang-Claude, Stephen J. Chanock, Kexin Chen, Yoke-Eng Chiew, Wendy K. Chung, Kathleen B. M. Claes, Sarah Colonna, Linda S. Cook, Fergus J. Couch, Mary B. Daly, Fanny Dao, Eleanor Davies, Miguel de la Hoya, Robin de Putter, Joe Dennis, Allison DePersia, Peter Devilee, Orland Diez, Yuan Chun Ding, Jennifer A. Doherty, Susan M. Domchek, Thilo Dork, Andreas du Bois, Matthias Durst, Diana M. Eccles, Heather A. Eliassen, Christoph Engel, Gareth D. Evans, Peter A. Fasching, James M. Flanagan, ReneeT Fortner, Eva Machackova, Eitan Friedman, Patricia A. Ganz, Judy Garber, Francesca Gensini, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Mark H. Greene, Jacek Gronwald, Opal Study Group, AOCSGroup, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Ute Hamann, Thomas V. O. Hansen, Holly R. Harris, Mikael Hartman, Florian Heitz, Michelle A. T. Hildebrandt, Estrid Hogdall, Claus K. Hogdall, John L. Hopper, Ruea-Yea Huang, Chad Huff, Peter J. Hulick, David G. Huntsman, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Allan Jensen, Oskar Th Johannsson, Esther M. John, Michael E. Jones, Daehee Kang, Beth Y. Karlan, Anthony Karnezis, Linda E. Kelemen, Elza Khusnutdinova, Lambertus A. Kiemeney, Byoung-Gie Kim, Susanne K. Kjaer, Ian Komenaka, Jolanta Kupryjanczyk, Allison W. Kurian, Ava Kwong, Diether Lambrechts, Melissa C. Larson, Conxi Lazaro, Nhu D. Le, Goska Leslie, Jenny Lester, Fabienne Lesueur, Douglas A. Levine, Lian Li, Jingmei Li, Jennifer T. Loud, Karen H. Lu, Phuong L. Mai, Siranoush Manoukian, Jeffrey R. Marks, Rayna KimMatsuno, Keitaro Matsuo, Taymaa May, Lesley McGuffog, John R. McLaughlin, Iain A. McNeish, Noura Mebirouk, Usha Menon, Austin Miller, Roger L. Milne, Albina Minlikeeva, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Elizabeth Munro, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Henriette Roed Nielsen, Finn C. Nielsen, Liene Nikitina-Zake, Kunle Odunsi, Kenneth Offit, Edith Olah, Siel Olbrecht, Olufunmilayo Olopade, Sara H. Olson, Hakan Olsson, Ana Osorio, Laura Papi, Sue K. Park, Michael T. Parsons, Harsha Pathak, Inge Sokilde Pedersen, Ana Peixoto, Tanja Pejovic, Pedro Perez-Segura, Jennifer B. Permuth, Beth Peshkin, Paolo Peterlongo, Anna Piskorz, Darya Prokofyeva, Paolo Radice, Johanna Rantala, Marjorie J. Riggan, Harvey A. Risch, Cristina Rodriguez-Antona, Eric Ross, Mary Anne Rossing, Ingo Runnebaum, Dale P. Sandler, Marta Santamarina, Penny Soucy, Rita K. Schmutzler, V. Wendy Setiawan, Kang Shan, Weiva Sieh, Jacques Simard, Christian F. Singer, Anna P. Sokolenko, Honglin Song, Melissa C. Southey, Helen Steed, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Anthony J. Swerdlow, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Kathryn L. Terry, Mary BethTerry, Mads Thomassen, Pamela J. Thompson, Liv Cecilie Vestrheim Thomsen, Darcy L. Thull, Marc Tischkowitz, Linda Titus, Amanda E. Toland, Diana Torres, Britton Trabert, Ruth Travis, Nadine Tung, Shelley S. Tworoger, Ellen Valen, Anne M. van Altena, Annemieke H. van der Hout, ElsVan Nieuwenhuysen, Elizabeth J. van Rensburg, Ana Vega, Digna Velez Edwards, Robert A. Vierkant, Frances Wang, Barbara Wappenschmidt, Penelope M. Webb, Clarice R. Weinberg, Jeffrey N. Weitzel, Nicolas Wentzensen, Emily White, Alice S. Whittemore, Stacey J. Winham, Alicja Wolk, Yin-Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Katia M. Zavaglia, Wei Zheng, Argyrios Ziogas, Kristin K. Zorn, Zdenek Kleibl, Douglas Easton, Kate Lawrenson, Anna DeFazio, Thomas A. Sellers, Susan J. Ramus, Celeste L. Pearce, Alvaro N. Monteiro, Julie Cunningham, Ellen L. Goode, Joellen M. Schildkraut, Andrew Berchuck, Georgia Chenevix-Trench, Simon A. Gayther, Antonis C. Antoniou, Paul D. P. Pharoah
Summary: This study developed polygenic risk score models for risk prediction of epithelial non-mucinous ovarian cancer and validated their predictive value in diverse populations and BRCA1/BRCA2 mutation carriers, suggesting potential clinical utility in ovarian cancer prevention programs.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Genetics & Heredity
Hongyan Li, Christoph Engel, Miguel de la Hoya, Paolo Peterlongo, Drakoulis Yannoukakos, Luca Livraghi, Paolo Radice, Mads Thomassen, Thomas V. O. Hansen, Anne-Marie Gerdes, Henriette R. Nielsen, Sandrine M. Caputo, Alberto Zambelli, Ake Borg, Angela Solano, Abigail Thomas, Michael T. Parsons, Antonis C. Antoniou, Goska Leslie, Xin Yang, Georgia Chenevix-Trench, Trinidad Caldes, Ava Kwong, Inge Sokilde Pedersen, Charlotte K. Lautrup, Esther M. John, Mary Beth Terry, John L. Hopper, Melissa C. Southey, Irene L. Andrulis, Marc Tischkowitz, Ramunas Janavicius, Susanne E. Boonen, Lone Kroeldrup, Liliana Varesco, Ute Hamann, Ana Vega, Edenir Palmero, Judy Garber, Marco Montagna, Christi J. Van Asperen, Lenka Foretova, Mark H. Greene, Tina Selkirk, Pal Moller, Amanda E. Toland, Susan M. Domchek, Paul A. James, Heather Thorne, Diana M. Eccles, Sarah M. Nielsen, Siranoush Manoukian, Barbara Pasini, Maria A. Caligo, Conxi Lazaro, Judy Kirk, Barbara Wappenschmidt, Amanda B. Spurdle, Fergus J. Couch, Rita Schmutzler, David E. Goldgar
Summary: This study provides important implications for counseling high-risk women with missense pathogenic variants in BRCA1/2 genes, showing that the risks of breast cancer associated with missense variants are significantly lower than those associated with protein truncating variants.
GENETICS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Lauren C. Houghton, Ying Wei, Tianying Wang, Mandy Goldberg, Alejandra Paniagua-Avila, Rachel L. Sweeden, Angela Bradbury, Mary Daly, Lisa A. Schwartz, Theresa Keegan, Esther M. John, Julia A. Knight, Irene L. Andrulis, Saundra S. Buys, Caren J. Frost, Karen O'Toole, Melissa L. White, Wendy K. Chung, Mary Beth Terry
Summary: The study found that girls with earlier BMI rebound in childhood tend to experience puberty earlier, while those with older age at BMI rebound are more likely to experience delayed puberty. This association remained significant even after adjusting for other factors, especially after adjusting for BMI at age nine.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Orthopedics
Hiroko Matsumoto, Elaine L. Larson, Shay I. Warren, Bradley T. Hammoor, Lisa Bonsignore-Opp, Michael J. Troy, Kody K. Barrett, Brendan M. Striano, Gen Li, Mary Beth Terry, Benjamin D. Roye, Lawrence G. Lenke, David L. Skaggs, Michael P. Glotzbecker, John M. Flynn, David P. Roye, Michael G. Vitale
Summary: This study developed a risk probability calculator to predict the probability of 90-day SSI in pediatric spinal deformity surgery, encompassing patient, surgical, and hospital factors. It can improve informed consent and shared decision-making, and may allow the selective deployment of additional resources and strategies in high-risk patients.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Oncology
Shuai Li, Valentina Silvestri, Goska Leslie, Timothy R. Rebbeck, Susan L. Neuhausen, John L. Hopper, Henriette Roed Nielsen, Andrew Lee, Xin Yang, Lesley McGuffog, Michael T. Parsons, Irene L. Andrulis, Norbert Arnold, Muriel Belotti, Ake Borg, Bruno Buecher, Saundra S. Buys, Sandrine M. Caputo, Wendy K. Chung, Chrystelle Colas, Sarah Colonna, Jackie Cook, Mary B. Daly, Miguel de la Hoya, Antoine de Pauw, Helene Delhomelle, Jacqueline Eason, Christoph Engel, D. Gareth Evans, Ulrike Faust, Tanja N. Fehm, Florentia Fostira, George Fountzilas, Megan Frone, Vanesa Garcia-Barberan, Pilar Garre, Marion Gauthier-Villars, Andrea Gehrig, Gord Glendon, David E. Goldgar, Lisa Golmard, Mark H. Greene, Eric Hahnen, Ute Hamann, Helen Hanson, Tiara Hassan, Julia Hentschel, Judit Horvath, Louise Izatt, Ramunas Janavicius, Yue Jiao, Esther M. John, Beth Y. Karlan, Sung-Won Kim, Irene Konstantopoulou, Ava Kwong, Anthony Lauge, Jong Won Lee, Fabienne Lesueur, Noura Mebirouk, Alfons Meindl, Emmanuelle Mouret-Fourme, Hannah Musgrave, Joanne Ngeow Yuen Yie, Dieter Niederacher, Sue K. Park, Inge Sokilde Pedersen, Juliane Ramser, Susan J. Ramus, Johanna Rantala, Muhammad U. Rashid, Florian Reichl, Julia Ritter, Andreas Rump, Marta Santamarina, Claire Saule, Gunnar Schmidt, Rita K. Schmutzler, Leigha Senter, Saba Shariff, Christian F. Singer, Melissa C. Southey, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Tan, Soo Hwang Teo, Mary Beth Terry, Mads Thomassen, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Ana Vega, Sebastian A. Wagner, Shan Wang-Gohrke, Barbara Wappenschmidt, Bernhard H. F. Weber, Drakoulis Yannoukakos, Amanda B. Spurdle, Douglas F. Easton, Georgia Chenevix-Trench, Laura Ottini, Antonis C. Antoniou
Summary: This study aims to provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Lieske H. Schrijver, Thea M. Mooij, Anouk Pijpe, Gabe S. Sonke, Marian J. E. Mourits, Nadine Andrieu, Antonis C. Antoniou, Douglas F. Easton, Christoph Engel, David Goldgar, Esther M. John, Karin Kast, Roger L. Milne, Hakan Olsson, Kelly-Anne Phillips, Mary Beth Terry, John L. Hopper, Flora E. van Leeuwen, Matti A. Rookus
Summary: In BRCA1 and BRCA2 mutation carriers, the use of combined-type oral contraceptive preparation (COCP) initially increases the risk of breast, ovarian, and endometrial cancer, but in the long term, it significantly decreases the lifetime cancer risk. Risk-reducing bilateral salpingo-oophorectomy and menopausal hormone therapy counteract the long-term benefits of COCP use.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Biochemical Research Methods
Khue Nguyen, Masha Pitiranggon, Hui-Chen Wu, Esther M. John, Regina M. Santella, Mary Beth Terry, Beizhan Yan
Summary: This study demonstrates an efficient and reproducible method for measuring multiple polycyclic aromatic hydrocarbon metabolites in urinary samples. By optimizing the experimental steps and sample preparation, the method has improved sensitivity and recovery rates. This method is of great importance for epidemiology studies and biomonitoring programs.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hui-Chen Wu, Rebecca Kehm, Regina M. Santella, David J. Brenner, Mary Beth Terry
Summary: DNA repair phenotype is associated with cancer risk, and different DNA repair capacity is associated with different types of cancer risk. These findings support the potential use of DNA repair phenotype as a biomarker for cancer risk.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Samantha H. Jakuboski, Jasmine A. McDonald, Mary Beth Terry
Summary: Before the recommended age for mammography-based breast cancer screening, identifying high-risk women for early screening and targeted chemoprevention mainly relies on clinical guidelines based on family history and known mutations. However, relying solely on guidelines could exacerbate breast cancer health disparities. Non-Hispanic black women continue to experience higher rates of early-onset breast cancer and mortality, while reporting lower rates of family history compared to non-Hispanic white women. This highlights the importance of genetic testing to identify high-risk non-Hispanic black women early on for tailored risk reduction and screening programs.
Article
Oncology
Thomas U. Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L. Milne, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Borresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Bruening, Barbara Burwinkel, Saundra S. Buys, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, Christine L. Clarke, J. Margriet Collee, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Miriam Dwek, Diana M. Eccles, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M. Gapstur, Jose A. Garcia-Saenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, Anna Gonzalez-Neira, Grethe I. Grenaker Alnaes, Mervi Grip, Pascal Guenel, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Milena Jakimovska, Anna Jakubowska, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N. Kristensen, Ute Kruger, Katerina Kubelka-Sabit, Allison W. Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G. Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona McLean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G. Newman, Jesse Nodora, Kenneth Offit, Hakan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkas, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Ruediger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Ben Schottker, Mark E. Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Diana Torres, Melissa A. Troester, Celine M. Vachon, Carolien H. M. van Deurzen, Elke M. van Veen, Philippe Wagner, Clarice R. Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Fergus J. Couch, Jacques Simard, Peter Kraft, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Montserrat Garcia-Closas, Nilanjan Chatterjee
Summary: This study identifies breast cancer susceptibility variants that are associated with tumor features and intrinsic molecular subtypes, providing insights for subtype-specific risk prediction.
BREAST CANCER RESEARCH
(2022)
