Article
Environmental Sciences
Federica Ghelli, Valeria Bellisario, Giulia Squillacioti, Marco Panizzolo, Alfredo Santovito, Roberto Bono
Summary: This study investigated alterations in oxidative and inflammatory status among hospital workers, finding significantly higher levels of 15-F-2t-IsoP, MDA, and TNF-alpha in those exposed to formaldehyde. The air formaldehyde levels were positively correlated with oxidative and inflammatory markers.
Review
Genetics & Heredity
Jing Ye, Yi-Yang Mu, Jiong Wang, Xiao-Feng He
Summary: This study investigated the association between GSTM1 and GSTT1 null genotypes and the risk of cervical or ovarian cancer. The overall analysis showed that GSTM1 null genotype was associated with increased risk of cervical cancer, while GSTT1 null genotype was not significantly associated with cervical cancer. For ovarian cancer, GSTM1 null genotype was associated with increased risk in East Asia, and GSTT1 null genotype was associated with increased risk in South America. However, the confidence of these associations was low.
FRONTIERS IN GENETICS
(2023)
Article
Virology
Mohammad Abbas, Sushma Verma, Shrikant Verma, Sahabjada Siddiqui, Faizan H. Khan, Syed T. Raza, Zeba Siddiqi, Ale Eba, Farzana Mahdi
Summary: This study investigated the role of GSTM1 and GSTT1 gene polymorphism in COVID-19 susceptibility and outcomes. The frequency of GSTM1(-/-), GSTT1(-/-), and GSTM1(-/-)/GSTT1(-/-) was higher in severe COVID-19 patients, but no significant association was observed. Patients with the GSTT1(-/-) genotype showed higher mortality, with death being 2.28-fold higher in this group according to the Cox hazard model.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Genetics & Heredity
Yan Zhao, Di Wang, Cheng-Yu Zhang, Yan-Ju Liu, Xiao-Hui Wang, Meng-Ying Shi, Wei Wang, Xu-Liang Shen, Xiao-Feng He
Summary: This study found that GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms are associated with leukemia risk, but the combined effects are not significant. A significant increase in leukemia risk was observed only for the GSTT1 null genotype in Asians.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
Giovana Nakanishi, Laisa S. Bertagnolli, Murilo Pita-Oliveira, Mariana M. Scudeler, Sabrina Torres-Loureiro, Thais Almeida-Dantas, Maria Laura C. Alves, Heithor S. Cirino, Fernanda Rodrigues-Soares
Summary: GSTM1 and GSTT1 deletions show significant frequency differences among distinct ethnic groups, with East Asians having the highest frequencies and Sub-Saharan Africans having the lowest, indicating a strong influence of ethnicity. Further studies on the impact of admixture on the frequency values of these genes are needed.
DRUG METABOLISM REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Leticia Madureira Pacholak, Rodrigo Kern, Stefania Tagliari de Oliveira, Leia Carolina Lucio, Marla Karine Amarante, Roberta Losi Guembarovski, Maria Angelica Ehara Watanabe, Carolina Panis
Summary: The study found that polymorphisms in GSTM1 and GSTT1 genes were not associated with breast cancer susceptibility, and did not have a significant impact on GSH levels in patients. Further research is needed to understand the relationship between these polymorphisms and breast cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Genetics & Heredity
Ayatun Nesa, Md. Mostafijur Rahman, Md Tahminur Rahman, Yearul Kabir
Summary: This study aimed to investigate the association of NAT2, GSTT1, and GSTM1 gene polymorphisms with prostate cancer risk in the Bangladeshi population. The results showed a higher frequency of mutant NAT2*5A, NAT2*6A, and NAT2*7A in prostate cancer cases compared to controls. The presence of NAT2 slow genotypes, GSTT1 genotype, and GSTM1 genotype significantly increased the risk of prostate cancer.
Review
Biochemistry & Molecular Biology
Ana Paula Reolon Bortolli, Valquiria Kulig Vieira, Emi Elaine Stefanski, Angela Khetly Lazarotto, Leia Carolina Lucio
Summary: This study reviewed the relationship between GSTT1 and GSTM1 and HPV infection in women, finding a probable association between single nucleotide polymorphisms and cervical lesions or cancer, and that GSTT1 null alleles were more common in women with more aggressive HPV.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jianming Fang, Fazhuang Fang, Jianxin Huang, Xiaodong Zhang, Hongjuan Wang
Summary: This study explores the relationship between GSTMI and GSTT1 gene polymorphisms and gallbladder cancer and finds that the deletion frequency of these two genes significantly reduces after treatment. Therefore, conducting gene testing before surgical treatment of gallbladder cancer can improve treatment effect.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Review
Genetics & Heredity
Ting Hu, Guozhong Zhou, Wenjin Li
Summary: The study found that the individual GSTM1 and GSTT1 null genotypes and combined effects of the two genes are significantly associated with an increased risk of leukemia, especially in Asians; the GSTT1 null genotype is associated with an increased risk of AML; the combined effects of the two genes are associated with an increased risk of leukemia in Indians.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Baiming Jin, Siyuan Wan, Michael Boah, Jie Yang, Wenjing Ma, Man Lv, Haonan Li, Kewei Wang
Summary: This study found a significant negative correlation between the GSTM1 null genotype and susceptibility to arsenic poisoning, while the GSTT1 single null genotype and GSTM1-GSTT1 dual-null genotype were not associated with the risk of arsenic poisoning. Individuals with the GSTM1 null genotype may have lower susceptibility to arsenic poisoning.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Genetics & Heredity
Liang-shu Liu, Di Wang, Ru Tang, Qi Wang, Lu Zheng, Jian Wei, Yan Li, Xiao-feng He
Summary: This study investigates the relationship between glutathione-S-transferase polymorphisms and type 2 diabetes mellitus risk. The results suggest that individual variants of GSTM1, GSTT1 and GSTP1 may be associated with increased T2DM risk, but the combined effects are not statistically significant. Additionally, specific genotypes are linked to higher T2DM risk in certain populations.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Abozer Y. Elderdery, Hadeil M. E. Idris, Entesar M. Tebien, Nada Abdalfatah Diab, Siddiqa M. A. Hamza, Bandar A. Suliman, Abdulaziz H. Alhamidi, Nawal Eltayeb Omer, Jeremy Mills
Summary: The study found a strong correlation between GSTT1 polymorphism and the development of Ph-ve CML, while GSTM1 polymorphism did not play a role in the initial development of the disease. Further research is needed to clarify the roles of other genes in disease development.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Ana Paula Reolon Bortolli, Valquiria Kulig Vieira, Indianara Carlotto Treco, Claudiceia Risso Pascotto, Guilherme Welter Wendt, Leia Carolina Lucio
Summary: This study aimed to investigate the relationship between GSTM1 and GSTT1 genetic polymorphisms and HPV infection and associated risk factors in a group of women assisted in the public health system of southwestern Parana, Brazil. The results showed that the GSTT1 null allele was a protective factor against infection.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Wen-Ping Zhang, Chen Yang, Ling-Jun Xu, Wei Wang, Liang Song, Xiao-Feng He
Summary: This study found that the GSTM1 null genotype is associated with an increased risk of lung cancer in Japanese individuals, while the GSTT1 and GSTP1 IIe105Val polymorphisms are significantly related to lung cancer risk in Asians.
Article
Oncology
Hamed Khalili, Jian Gong, Hermann Brenner, Thomas R. Austin, Carolyn M. Hutter, Yoshifumi Baba, John A. Baron, Sonja I. Berndt, Stephane Bezieau, Bette Caan, Peter T. Campbell, Jenny Chang-Claude, Stephen J. Chanock, Constance Chen, Li Hsu, Shuo Jiao, David V. Conti, David Duggan, Charles S. Fuchs, Manish Gala, Steven Gallinger, Robert W. Haile, Tabitha A. Harrison, Richard Hayes, Aditi Hazra, Brian Henderson, Chris Haiman, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Laurence N. Kolonel, Sebastien Kuery, Andrea LaCroix, Loic Le Marchand, Mathieu Lemire, Noralane M. Lindor, Jing Ma, Joann E. Manson, Teppei Morikawa, Hongmei Nan, Kimmie Ng, Polly A. Newcomb, Reiko Nishihara, John D. Potter, Conghui Qu, Robert E. Schoen, Fredrick R. Schumacher, Daniela Seminara, Darin Taverna, Stephen Thibodeau, Jean Wactawski-Wende, Emily White, Kana Wu, Brent W. Zanke, Graham Casey, Thomas J. Hudson, Peter Kraft, Ulrike Peters, Martha L. Slattery, Shuji Ogino, Andrew T. Chan
Article
Oncology
John A. Heath, Jeanette C. Reece, Daniel D. Buchanan, Graham Casey, Carol A. Durno, Steven Gallinger, Robert W. Haile, Polly A. Newcomb, John D. Potter, Stephen N. Thibodeau, Loic Le Marchand, Noralane M. Lindor, John L. Hopper, Mark A. Jenkins, Aung Ko Win
Article
Gastroenterology & Hepatology
Li Hsu, Jihyoun Jeon, Hermann Brenner, Stephen B. Gruber, Robert E. Schoen, Sonja I. Berndt, Andrew T. Chan, Jenny Chang-Claude, Mengmeng Du, Jian Gong, Tabitha A. Harrison, Richard B. Hayes, Michael Hoffmeister, Carolyn M. Hutter, Yi Lin, Reiko Nishihara, Shuji Ogino, Ross L. Prentice, Fredrick R. Schumacher, Daniela Seminara, Martha L. Slattery, Duncan C. Thomas, Mark Thornquist, Polly A. Newcomb, John D. Potter, Yingye Zheng, Emily White, Ulrike Peters
Article
Gastroenterology & Hepatology
Amanda I. Phipps, Paul J. Limburg, John A. Baron, Andrea N. Burnett-Hartman, Daniel J. Weisenberger, Peter W. Laird, Frank A. Sinicrope, Christophe Rosty, Daniel D. Buchanan, John D. Potter, Polly A. Newcomb
Letter
Multidisciplinary Sciences
John D. Potter, Ross L. Prentice
Article
Multidisciplinary Sciences
Fredrick R. Schumacher, Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, Shu-Chen Huang, Christopher P. Fischer, John F. Harju, Gregory E. Idos, Flavio Lejbkowicz, Frank J. Manion, Kevin McDonnell, Caroline E. McNeil, Marilena Melas, Hedy S. Rennert, Wei Shi, Duncan C. Thomas, David J. Van Den Berg, Carolyn M. Hutter, Aaron K. Aragaki, Katja Butterbach, Bette J. Caan, Christopher S. Carlson, Stephen J. Chanock, Keith R. Curtis, Charles S. Fuchs, Manish Gala, Edward L. Giocannucci, Stephanie M. Gogarten, Richard B. Hayes, Brian Henderson, David J. Hunter, Rebecca D. Jackson, Laurence N. Kolonel, Charles Kooperberg, Sebastian Kury, Andrea LaCroix, Cathy C. Laurie, Cecelia A. Laurie, Mathiew Lemire, David Levine, Jing Ma, Karen W. Makar, Conghui Qu, Darin Taverna, Cornelia M. Ulrich, Kana Wu, Suminori Kono, Dee W. West, Sonja I. Berndt, Stephane Bezieau, Hermann Brenner, Peter T. Campbell, Andrew T. Chan, Jenny Chang-Claude, Gerhard A. Coetzee, David V. Conti, David Duggan, Jane C. Figueiredo, Barbara K. Fortini, Steven J. Gallinger, W. James Gauderman, Graham Giles, Roger Green, Robert Haile, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, Eric Jacobs, Motoki Iwasaki, Sun Ha Jee, Mark Jenkins, Wei-Hua Jia, Amit Joshi, Li Li, Noralene M. Lindor, Keitaro Matsuo, Victor Moreno, Bhramar Mukherjee, Polly A. Newcomb, John D. Potter, Leon Raskin, Gad Rennert, Stephanie Rosse, Gianluca Severi, Robert E. Schoen, Daniela Seminara, Xiao-Ou Shu, Martha L. Slattery, Shoichiro Tsugane, Emily White, Yong-Bing Xiang, Brent W. Zanke, Wei Zheng, Loic Le Marchand, Graham Casey, Stephen B. Gruber, Ulrike Peters
NATURE COMMUNICATIONS
(2015)
Article
Oncology
Driss Ait Ouakrim, Seyedeh Ghazaleh Dashti, Rowena Chau, Daniel D. Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Joanne P. Young, Graham G. Giles, Barbara Leggett, Finlay A. Macrae, Dennis J. Ahnen, Graham Casey, Steven Gallinger, Robert W. Haile, Loic Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins, Aung Ko Win
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2015)
Article
Oncology
Neil Murphy, Howard D. Strickler, Frank Z. Stanczyk, Xiaonan Xue, Sylvia Wassertheil-Smoller, Thomas E. Rohan, Gloria Y. F. Ho, Garnet L. Anderson, John D. Potter, Marc J. Gunter
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2015)
Article
Oncology
Noha Sharafeldin, Martha L. Slattery, Qi Liu, Conrado Franco-Villalobos, Bette J. Caan, John D. Potter, Yutaka Yasui
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2015)
Article
Environmental Sciences
Noha Sharafeldin, Martha L. Slattery, Qi Liu, Conrado Franco-Villalobos, Bette J. Caan, John D. Potter, Yutaka Yasui
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2017)
Article
Oncology
Xiaoliang Wang, Andrew T. Chan, Martha L. Slattery, Jenny Chang-Claude, John D. Potter, Steven Gallinger, Bette Caan, Johanna W. Lampe, Polly A. Newcomb, Niha Zubair, Li Hsu, Robert E. Schoen, Michael Hoffmeister, Hermann Brenner, Loic Le Marchand, Ulrike Peters, Emily White
Article
Oncology
Matthew G. Varga, Julia Butt, William J. Blot, Loic Le Marchand, Christopher A. Haiman, Yu Chen, Sylvia Wassertheil-Smoller, Lesley F. Tinker, Richard M. Peek, John D. Potter, Timothy L. Cover, Terry Hyslop, Anne Zeleniuch-Jacquotte, Sonja Berndt, Allan Hildesheim, Tim Waterboer, Michael Pawlita, Meira Epplein
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Editorial Material
Public, Environmental & Occupational Health
Jeroen Douwes, Collin R. Brooks, Geoffrey H. Donovan, John D. Potter
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Review
Environmental Sciences
John D. Potter, Collin Brooks, Geoffrey Donovan, Chris Cunningham, Jeroen Douwes
Summary: Humans' encroachment into wild spaces has profound impacts on our relationship with nature, the survival of other species, pollution, and climate change. The benefits of being close to green and blue spaces are discussed, while the hazards of urban grey spaces are highlighted. The biodiversity hypothesis and the role of microbiota are emphasized, along with possible mechanisms of exposure through air, soil, and water. The importance of assessing exposure accurately and the need for implementing policies to restore environmental balance are also emphasized.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Genetics & Heredity
Sushma S. Thomas, Karen W. Makar, Lin Li, Yingye Zheng, Peiying Yang, Lisa Levy, Rebecca Y. Rudolph, Paul D. Lampe, Min Yan, Sanford D. Markowitz, Jeannette Bigler, Johanna W. Lampe, John D. Potter