Article
Genetics & Heredity
Oleksii Nikolaienko, Hans P. Eikesdal, Elisabet Ognedal, Bjornar Gilje, Steinar Lundgren, Egil S. Blix, Helge Espelid, Jurgen Geisler, Stephanie Geisler, Emiel A. M. Janssen, Synnove Yndestad, Laura Minsaas, Beryl Leirvaag, Reidun Lillestol, Stian Knappskog, Per E. Lonning
Summary: This study found that approximately 20% of TNBC and low-ER expression breast cancers may be caused by prenatal BRCA1 epimutations. The constitutional mosaic BRCA1 methylation likely arises through gender-related mechanisms in utero, independent of Mendelian inheritance.
Article
Virology
Ashley E. Strother, Jill K. Thompson, Steven G. Widen, Alan D. T. Barrett
Summary: The yellow fever disease was prevented by two live attenuated vaccines, strains 17D and French neurotropic vaccine (FNV), derived from wild-type strains Asibi and French Viscerotropic virus (FVV) through serial passage. The genome sequence of FVV was determined after five passages in HeLa cells, and it was found that the FVV HeLa p5 virus had five amino acid substitutions compared to the parental strain. Surprisingly, the genetic diversity and Ribavirin resistance of the FVV HeLa p5 virus were not statistically different to the parental strain.
Article
Cell Biology
Keertana Srimat Kandadai, Monika B. Kotur, Nikolaos Dokalis, Irmgard Amrein, Christian W. Keller, Christian Muenz, David Wolfer, Marco Prinz, Jan D. Luenemann
Summary: The study shows that the loss of ATG5 in adult microglia does not affect CNS tissue integrity, microglial cell survival, immune activation, learning task performance, or the development of experimental autoimmune encephalomyelitis. This suggests that ATG5 expression in microglia is not essential for maintaining CNS homeostasis or for the development of autoimmune neuroinflammation.
Article
Biotechnology & Applied Microbiology
Maya Hiltpold, Naveen Kumar Kadri, Fredi Janett, Ulrich Witschi, Fritz Schmitz-Hsu, Hubert Pausch
Summary: The study identified novel recessive QTL for male fertility in Brown Swiss cattle, with one QTL associated with sperm head shape anomalies. Fine-mapping approaches and whole-genome sequencing revealed candidate causal variants linked to these QTL, suggesting that non-coding variants may play a significant role in bull fertility variation.
Article
Oncology
Yue Jiao, Therese Truong, Severine Eon-Marchais, Noura Mebirouk, Sandrine M. Caputo, Marie-Gabrielle Dondon, Mojgan Karimi, Dorothee Le Gal, Juana Beauvallet, Edith Le Floch, Claire Dandine-Roulland, Delphine Bacq-Daian, Robert Olaso, Juliette Albuisson, Severine Audebert-Bellanger, Pascaline Berthet, Valerie Bonadona, Bruno Buecher, Olivier Caron, Mathias Cavaille, Jean Chiesa, Chrystelle Colas, Marie-Agnes Collonge-Rame, Isabelle Coupier, Capucine Delnatte, Antoine De Pauw, Helene Dreyfus, Sandra Fert-Ferrer, Marion Gauthier-Villars, Paul Gesta, Sophie Giraud, Laurence Gladieff, Lisa Golmard, Christine Lasset, Sophie Lejeune-Dumoulin, Melanie Leone, Jean-Marc Limacher, Alain Lortholary, Elisabeth Luporsi, Veronique Mari, Christine M. Maugard, Isabelle Mortemousque, Emmanuelle Mouret-Fourme, Sophie Nambot, Catherine Nogues, Cornel Popovici, Fabienne Prieur, Pascal Pujol, Nicolas Sevenet, Hagay Sobol, Christine Toulas, Nancy Uhrhammer, Dominique Vaur, Laurence Venat, Anne Boland-Auge, Pascal Guenel, Jean-Francois Deleuze, Dominique Stoppa-Lyonnet, Nadine Andrieu, Fabienne Lesueur
Summary: The three breast cancer polygenic risk scores (PRS) were associated with breast cancer risk in French women, but the predictive performance varied among different populations. The PRS were useful for women with a strong family history and no BRCA1/2 pathogenic variant, as well as those carrying a predicted pathogenic variant in a moderate-risk gene (ATM, CHEK2 or PALB2). Further research on the application of these scores in different populations is warranted.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Microbiology
Patricia L. Foster, Brittany A. Niccum, Heewook Lee
Summary: Encounters between DNA replication and transcription may lead to genomic disruption, but whether this contributes to mutations is debated. This study found that in mismatch repair-defective E. coli, there were no significant differences in mutation frequencies between genes oriented codirectionally and those oriented head-on to replication. Biases in mutation frequencies among highly expressed genes were mainly due to the positions of tRNA genes containing mononucleotide runs.
Article
Medicine, Research & Experimental
Simeng Wang, Qingzhang Zhu, Guosheng Liang, Tania Franks, Magalie Boucher, Kendra K. Bence, Mingjian Lu, Carlos M. Castorena, Shangang Zhao, Joel K. Elmquist, Philipp E. Scherer, Jay D. Horton
Summary: Studies using mice lacking CB-1 in hepatocytes or stellate cells suggest that CB-1 signaling does not directly contribute to the development of NAFLD or liver fibrosis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Transportation Science & Technology
Michel Villot, Philippe Jean, Catherine Guigou-Carter
Summary: The study estimated the sound radiated by ground vibration generated by trains through calculation and compared it to total sound measured on-site, finding that ground-borne sound radiated dominates at low frequencies. It suggests that the ground should be considered as a separate sound source when dealing with railway noise.
INTERNATIONAL JOURNAL OF RAIL TRANSPORTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Daein Choi, Waqas A. Malick, Wolfgang Koenig, Daniel J. Rader, Robert S. Rosenson
Summary: The availability of statins, ezetimibe, and PCSK9 inhibitors has improved the prognosis of familial hypercholesterolemia (FH), but many patients still have high LDL cholesterol levels. Novel therapies that lower LDL independent of LDL receptor activity can mitigate atherosclerotic cardiovascular disease risk for many FH patients. However, access to these therapies remains limited for some FH patients. Clinical trials in FH patients face challenges in recruitment and long-term follow-up, but the use of surrogate measures of atherosclerosis may expedite access to novel treatments.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Nikita Saha Turna, Arie Havelaar, Adegbola Adesogan, Felicia Wu
Summary: Exposure to AFM1 through liquid milk consumption does not substantially increase the risk of liver cancer in humans. Policymakers should consider this low risk against the nutritional benefits of milk consumption, especially for children, in the current global situation of milk being discarded due to AFM1 concentrations exceeding regulatory standards.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Engineering, Environmental
Qi Zhang, Zhenyan Zhang, Shuyidan Zhou, Mingkang Jin, Tao Lu, Li Cui, Haifeng Qian
Summary: Global attention is being paid to the abuse of antibiotics and their health risks, with the European Union and China banning antibiotic additives in fodder. This study compared the effects of antibiotics and alternatives on soil microbiomes, finding that the alternative Macleaya cordata extract poses a lower ecological risk than antibiotics.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Physical
Leonardo F. Calderon, Chern Chuang, Paul Brumer
Summary: Research shows that vibrations resonant with the energy difference between exciton states in photosynthetic dimers only have a marginal effect on energy transfer and quantum coherence compared to non-resonant vibrations under natural incoherent light excitation conditions.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Oncology
Marzia Del Re, Stefania Crucitta, Claudia Omarini, Irene Bargagna, Marta Mongillo, Michela Palleschi, Stefania Stucci, Icro Meattini, Raffaella D'Onofrio, Giulia Lorenzini, Pamela Biondani, Ugo De Giorgi, Camillo Porta, Lorenzo Livi, Salvatore Natalizio, Andrea Fontana, Elena Giontella, Lucia Angelini, Stefano Fogli, Romano Danesi
Summary: This study found that the concomitant use of proton-pump inhibitors does not compromise the efficacy of ribociclib in a real-life setting.
Article
Oncology
Yannick Fabian Diehm, Katharina Marstaller, Anna-Maria Seckler, Martin Reinhold Berger, Michael Zepp, Matthias Martin Gaida, Julia Thome, Dimitra Kotsougiani-Fischer, Ulrich Kneser, Sebastian Fischer
Summary: This study investigated the impact of CCH treatment on breast cancer cells. The results showed that CCH had an effect on the proliferation and wound healing of breast cancer cells in vitro and in vivo, but did not significantly change the cell cycle and apoptosis. No evidence of metastasis was observed in the in vivo experiments, and no relevant alterations in metastasis-related genes were detected. Therefore, CCH does not have an impact on tumor growth or metastasis formation.
Article
Biochemistry & Molecular Biology
Jihong Lian, Jelske N. van der Veen, Russell Watts, Rene L. Jacobs, Richard Lehner
Summary: This study investigated the role of hepatic Ces1d in cholesterol homeostasis using liver-specific Ces1d-deficient mice. The findings indicated that the absence of Ces1d did not affect RCT flux or cause additional liver CE accumulation after a high-cholesterol diet challenge, challenging the importance of Ces1d as a major hepatic CE hydrolase.
JOURNAL OF LIPID RESEARCH
(2021)