Article
Oncology
Mark Liebow, Melissa C. Larson, Carrie A. Thompson, Grzegorz S. Nowakowski, Timothy G. Call, William R. Macon, Neil E. Kay, Thomas M. Habermann, Susan L. Slager, James R. Cerhan
Summary: The study found that regular use of low-dose aspirin may reduce the risk of non-Hodgkin lymphoma, while other NSAIDs and statins showed no association with NHL risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
James Yarmolinsky, Christopher I. Amos, Rayjean J. Hung, Victor Moreno, Kimberley Burrows, Karl Smith-Byrne, Joshua R. Atkins, Paul Brennan, James D. McKay, Richard M. Martin, George Davey Smith
Summary: Deucravacitinib, a selective TYK2 inhibitor, is being reviewed for the treatment of psoriasis. However, there are concerns about the safety of TYK2 inhibition due to the increased risk of lung cancer and non-Hodgkin lymphoma associated with similar medications. Genetic analysis using a loss-of-function variant in TYK2 showed an increased risk of lung cancer and non-Hodgkin lymphoma with therapeutic TYK2 inhibition. These findings have important implications for the safety assessment of deucravacitinib and other TYK2 inhibitors.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Ani Stepanyan, Anna Petrackova, Siras Hakobyan, Jakub Savara, Suren Davitavyan, Eva Kriegova, Arsen Arakelyan
Summary: This study investigated the association between plasma levels of 21 metals and the methylation status of 654 CpG sites located on NFKB1, CDKN2A, ESR1, APOA5, IGF2 and H19 genes in individuals living near metal mining area. The results revealed methylation changes in NFKB1, CDKN2A, IGF2 and ESR1 genes in individuals with long-term exposure to metals. Further studies are needed to explore the effects of environmental metal exposure on epigenetic mechanisms and pathways involved.
CLINICAL EPIGENETICS
(2023)
Article
Hematology
Simone de Vries, Inge M. Krul, Michael Schaapveld, Cecile P. M. Janus, Saskia E. Rademakers, Judith M. Roesink, Marten R. Nijziel, Berthe M. P. Aleman, Flora E. van Leeuwen
Summary: Male survivors of Hodgkin lymphoma who received chest radiotherapy have a significantly increased risk of breast cancer. The risk is higher for those who received chest radiotherapy and alkylating chemotherapy compared to those who only received chest radiotherapy.
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Hematology
Christian W. Thorball, Tiphaine Oudot-Mellakh, Nava Ehsan, Christian Hammer, Federico A. Santoni, Jonathan Niay, Dominique Costagliola, Cecile Goujard, Laurence Meyer, Sophia S. Wang, Shehnaz K. Hussain, Ioannis Theodorou, Matthias Cavassini, Andri Rauch, Manuel Battegay, Matthias Hoffmann, Patrick Schmid, Enos Bernasconi, Huldrych F. Gunthard, Pejman Mohammadi, Paul J. McLaren, Charles S. Rabkin, Caroline Besson, Jacques Fellay
Summary: HIV-infected individuals have a higher risk of developing non-Hodgkin lymphoma (NHL), with a significant association found in the CXCL12 region on chromosome 10. A specific polymorphism, rs7919208, was identified as the most likely causal variant.
Article
Immunology
Laura E. Martinez, Larry I. Magpantay, Yu Guo, Priya Hegde, Roger Detels, Shehnaz K. Hussain, Marta Epeldegui
Summary: The study revealed significantly higher levels of EVs bearing PD-L1, CD40, TNF-RII, and/or IL-6R alpha in AIDS-NHL cases compared to controls. EVs carrying these molecules were found to be significantly and positively associated with AIDS-NHL risk, suggesting their potential as biomarkers for early detection of NHL in PLWH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
AnnaLynn M. Williams, Sedigheh Mirzaei Salehabadi, Mengqi Xing, Nicholas S. Phillips, Matthew J. Ehrhardt, Rebecca Howell, Yutaka Yasui, Kevin C. Oeffinger, Todd Gibson, Eric J. Chow, Wendy Leisenring, Deokumar Srivastava, Melissa M. Hudson, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull
Summary: Long-term survivors of childhood Hodgkin lymphoma (HL) face a high risk of neurocognitive and psychosocial impairment. Smoking and lack of exercise are associated with neurocognitive and psychosocial issues.
Article
Multidisciplinary Sciences
Stefan Nagel, Corinna Meyer, Claudia Pommerenke
Summary: The human family of ETS transcription factors consists of 28 genes that control various aspects of development, including blood and immune cell differentiation. Abnormal expression of ETS genes has been linked to the development of leukemia and lymphoma. In this study, the researchers mapped the activities of ETS genes in early hematopoiesis, lymphopoiesis, and mature lymphocytes using public datasets. They identified deregulated ETS genes in patients with lymphoid malignancies, particularly Hodgkin lymphoma (HL). The study also uncovered the oncogenic activity of ETS gene ETV3 in HL and identified other aberrantly expressed ETS genes in B-cell development. The findings provide valuable insights into the role of ETS genes in lymphopoiesis and the development of lymphoid malignancies.
Article
Endocrinology & Metabolism
J. Bodden, D. Sun, G. B. Joseph, L. -W. Huang, C. Andreadis, M. Hughes-Fulford, T. F. Lang, T. M. Link
Summary: Limited information is available on bone loss in treated non-Hodgkin's lymphoma patients. This study found severe bone loss, a high rate of fractures, and a novel association between bone loss and the international prognostic index. The results showed that NHL patients experienced significantly greater vertebral density loss than controls, and greater vertebral density loss was associated with a higher likelihood of incident fractures.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Oncology
Zhenxing Lu, Yintong Teng, Xiaodong Ning, Hao Wang, Weijing Feng, Caiwen Ou
Summary: This study found that among patients with stage I and stage II classic Hodgkin lymphoma (cHL), the risk of cardiovascular disease (CVD) mortality exceeded that of cHL mortality over time, with CVD becoming the leading cause of death.
Article
Hematology
Stephen M. Ansell
Summary: Hodgkin lymphoma is a rare lymphoma with two distinct disease types. Risk-adapted therapy based on histology, disease stage, and prognostic features is crucial for treatment. Newer agents like brentuximab vedotin and anti-PD1 antibodies have been incorporated into frontline therapy.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Editorial Material
Hematology
Ananth Shankar, Jamshed Bomanji
Summary: The management strategy for classical Hodgkin lymphoma in children aims to optimize therapeutic efficacy while minimizing treatment-related toxicity through a risk-adapted and response-based approach. A recent study by Milgrom et al. found that combining baseline volumetric quantitative PET data with early response assessment PET2 scan improved risk stratification in children with high-risk classical Hodgkin lymphoma treated on the COG AHOD0831 trial.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Maira A. Castaneda-Avila, Karen J. Ortiz-Ortiz, Carlos R. Torres-Cintron, Brenda M. Birmann, Mara M. Epstein
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Geffen Kleinstern, Huihuang Yan, Michelle A. T. Hildebrandt, Joseph Vijai, Sonja Berndt, Herve Ghesquieres, James McKay, Sophia S. Wang, Alexandra Nieters, Yuanqing Ye, Alain Monnereau, Angela R. Brooks-Wilson, Qing Lan, Mads Melbye, Rebecca D. Jackson, Lauren R. Teras, Mark P. Purdue, Claire M. Vajdic, Roel C. H. Vermeulen, Graham G. Giles, Pier Luigi Cocco, Brenda M. Birmann, Peter Kraft, Demetrius Albanes, Anne Zeleniuch-Jacquotte, Simon Crouch, Yawei Zhang, Vivekananda Sarangi, Yan Asmann, Kenneth Offit, Gilles Salles, Xifeng Wu, Karin E. Smedby, Christine F. Skibola, Susan L. Slager, Nathaniel Rothman, Stephen J. Chanock, James R. Cerhan
HUMAN MOLECULAR GENETICS
(2020)
Article
Public, Environmental & Occupational Health
Mara Meyer Epstein, Cassandra Saphirak, Yanhua Zhou, Candace LeBlanc, Alan G. Rosmarin, Arlene Ash, Sonal Singh, Kimberly Fisher, Brenda M. Birmann, Jerry H. Gurwitz
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Oncology
Geffen Kleinstern, Nicola J. Camp, Sonja I. Berndt, Brenda M. Birmann, Alexandra Nieters, Paige M. Bracci, James D. McKay, Herv E. Ghesquieres, Qing Lan, Henrik Hjalgrim, Yolanda Benavente, Alain Monnereau, Sophia S. Wang, Yawei Zhang, Mark P. Purdue, Anne Zeleniuch-Jacquotte, Graham G. Giles, Roel Vermeulen, Pierluigi Cocco, Demetrius Albanes, Lauren R. Teras, Angela R. Brooks-Wilson, Claire M. Vajdic, Eleanor Kane, Neil E. Caporaso, Karin E. Smedby, Gilles Salles, Joseph Vijai, Stephen J. Chanock, Christine F. Skibola, Nathaniel Rothman, Susan L. Slager, James R. Cerhan
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Dong Hoon Lee, Teresa T. Fung, Fred K. Tabung, Catherine R. Marinac, Elizabeth E. Devore, Bernard A. Rosner, Irene M. Ghobrial, Graham A. Colditz, Edward L. Giovannucci, Brenda M. Birmann
INTERNATIONAL JOURNAL OF CANCER
(2020)
Review
Oncology
Catherine R. Marinac, Irene M. Ghobrial, Brenda M. Birmann, Jenny Soiffer, Timothy R. Rebbeck
BLOOD CANCER JOURNAL
(2020)
Article
Oncology
Amy Moore, Eleanor Kane, Zhaoming Wang, Orestis A. Panagiotou, Lauren R. Teras, Alain Monnereau, Nicole Wong Doo, Mitchell J. Machiela, Christine F. Skibola, Susan L. Slager, Gilles Salles, Nicola J. Camp, Paige M. Bracci, Alexandra Nieters, Roel C. H. Vermeulen, Joseph Vijai, Karin E. Smedby, Yawei Zhang, Claire M. Vajdic, Wendy Cozen, John J. Spinelli, Henrik Hjalgrim, Graham G. Giles, Brian K. Link, Jacqueline Clavel, Alan A. Arslan, Mark P. Purdue, Lesley F. Tinker, Demetrius Albanes, Giovanni M. Ferri, Thomas M. Habermann, Hans-Olov Adami, Nikolaus Becker, Yolanda Benavente, Simonetta Bisanzi, Paolo Boffetta, Paul Brennan, Angela R. Brooks-Wilson, Federico Canzian, Lucia Conde, David G. Cox, Karen Curtin, Lenka Foretova, Susan M. Gapstur, Herve Ghesquieres, Martha Glenn, Bengt Glimelius, Rebecca D. Jackson, Qing Lan, Mark Liebow, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Lindsay M. Morton, Kari E. North, Kenneth Offit, Marina Padoan, Alpa V. Patel, Sara Piro, Vignesh Ravichandran, Elio Riboli, Silvia de Sanjose, Richard K. Severson, Melissa C. Southey, Anthony Staines, Carolyn Stewart, Ruth C. Travis, Elisabete Weiderpass, Stephanie Weinstein, Tongzhang Zheng, Stephen J. Chanock, Nilanjan Chatterjee, Nathaniel Rothman, Brenda M. Birmann, James R. Cerhan, Sonja I. Berndt
FRONTIERS IN ONCOLOGY
(2020)
Article
Medicine, General & Internal
Yin Zhang, Brenda M. Birmann, Jiali Han, Edward L. Giovannucci, Frank E. Speizer, Meir J. Stampfer, Bernard A. Rosner, Eva S. Schernhammer
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Article
Oncology
Lauren C. Peres, Mary K. Townsend, Brenda M. Birmann, Jose R. Conejo-Garcia, Yongjoo Kim, Laura D. Kubzansky, Larry Magpantay, Otoniel Martinez-Maza, Shelley S. Tworoger
Summary: This study found that elevated levels of CXCL13 may be associated with an increased risk of ovarian cancer, suggesting CXCL13 as a potential novel biomarker for the disease.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Letter
Environmental Sciences
Jakob Weitzer, Manfred D. Laubichler, Brenda M. Birmann, Martin Bertau, Lukas Zenk, Guido Caniglia, Carlo C. Jager, Gerald Steiner, Eva Schernhammer
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Hematology
Elsa Branvall, Sara Ekberg, Sandra Eloranta, Tove Wasterlid, Brenda M. Birmann, Karin E. Smedby
Summary: The study found that the use of statins was not consistently associated with any mortality outcome in NHL/CLL patients. For FL patients receiving active treatment, statin use did not increase lymphoma-specific mortality. However, in CLL patients, statin use was associated with all-cause and cardiovascular mortality but not consistently with lymphoma-specific mortality.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Catherine R. Marinac, Dong Hoon Lee, Graham A. Colditz, Timothy R. Rebbeck, Bernard Rosner, Mark Bustoros, Irene M. Ghobrial, Brenda M. Birmann
Summary: Aspirin use may reduce the risk of multiple myeloma-specific mortality and have a positive impact on overall survival. This study provides valuable information for the use of aspirin as a therapeutic option in multiple myeloma patients.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Obstetrics & Gynecology
Siwen Wang, Yi-Xin Wang, Helena Sandoval-Insausti, Leslie Farland, Jan L. Shifren, Dan Zhang, JoAnn E. Manson, Brenda M. Birmann, Walter C. Willett, Edward L. Giovannucci, Stacey A. Missmer, Jorge E. Chavarro
Summary: Women with irregular or long menstrual cycles in mid-adulthood had a statistically significantly higher risk of developing cancer, especially obesity-related cancers.
HUMAN REPRODUCTION
(2022)
Article
Oncology
Kimberly A. Bertrand, Lauren R. Teras, Emily L. Deubler, Chun R. Chao, Bernard A. Rosner, Ke Wang, Charlie Zhong, Sophia S. Wang, Brenda M. Birmann
Summary: This study found that early adult and usual adult obesity, as well as other measures of body composition such as BMI, waist circumference, and predicted fat mass, are associated with an increased risk of multiple myeloma. These findings emphasize the importance of avoiding overweight/obesity and excess adiposity throughout adulthood as a potential strategy for reducing the risk of multiple myeloma.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Catherine R. Marinac, Catherine A. Suppan, Edward Giovannucci, Mingyang Song, Ane S. Kvaerner, Mary K. Townsend, Bernard A. Rosner, Timothy R. Rebbeck, Graham A. Colditz, Brenda M. Birmann
JNCI CANCER SPECTRUM
(2019)